Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

Inside-Out Regulation of Fc RI (CD89) Depends on PP2A

(2014) J. E. Bakema et al.   JOURNAL OF IMMUNOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2+-CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells

(2013) Dingfang Liang et al.   BIOCHEMICAL PHARMACOLOGY

MEK drives cyclin D1 hyperelevation during geroconversion

(2013) O V Leontieva et al.   CELL DEATH AND DIFFERENTIATION

hsBAFF promotes proliferation and survival in cultured B lymphocytes via calcium signaling activation of mTOR pathway

(2013) Zhen Ke et al.   CYTOKINE

The Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Promotes DNA Hypomethylation by Suppressing the Phosphorylated Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)/Phosphorylated ERK/DNMT1 Protein Pathway in T-cells from Controls and Systemic Lupus Erythematosus Patients

(2013) Katsue Sunahori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased serum concentration of BAFF/APRIL and IgA2 subclass in patients with mixed connective tissue disease complicated by interstitial lung disease

(2013) Toshiyuki Kaneko et al.   Modern Rheumatology

Gene-function studies in systemic lupus erythematosus

(2013) José C. Crispín et al.   Nature Reviews Rheumatology

Updates of mTOR Inhibitors

(2012) Hongyu Zhou et al.   Anti-Cancer Agents in Medicinal Chemistry

Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells

(2012) Xiuzhen Han et al.   CARCINOGENESIS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

B cells in Sjögren's syndrome: From pathophysiology to diagnosis and treatment

(2012) Divi Cornec et al.   JOURNAL OF AUTOIMMUNITY

Cutting Edge: Protein Phosphatase 2A Confers Susceptibility to Autoimmune Disease through an IL-17-Dependent Mechanism

(2012) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The Gap-junction inhibitor Carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells

(2011) Li Endong et al.   JOURNAL OF NEUROIMMUNOLOGY

Induction of PP2A B , a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus

(2011) J. C. Crispin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B cells as therapeutic targets in SLE

(2010) Iñaki Sanz et al.   Nature Reviews Rheumatology

Rapamycin Inhibits IGF-1 Stimulated Cell Motility through PP2A Pathway

(2010) Lei Liu et al.   PLoS One

BAFF-R promotes cell proliferation and survival through interaction with IKKβ and NF-κB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells

(2009) Lingchen Fu et al.   BLOOD

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

BAFF: a local and systemic target in autoimmune diseases

(2009) I. Moisini et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta

(2008) Thomas Henley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

BAFF blockade for systemic lupus erythematosus: will the promise be fulfilled?

(2008) Meera Ramanujam et al.   IMMUNOLOGICAL REVIEWS

Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

(2008) Long Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transcriptional regulation of the cyclin D1 gene at a glance

(2008) E. A. Klein et al.   JOURNAL OF CELL SCIENCE

MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis

(2008) Long Chen et al.   JOURNAL OF NEUROCHEMISTRY

BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells

(2008) K. L. Otipoby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival

(2007) R. T. Woodland et al.   BLOOD

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL