Immune Cell Metabolism in Systemic Lupus Erythematosus

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Genetics of systemic lupus erythematosus and Sjögrenʼs syndrome

(2016) Maria Teruel et al.   CURRENT OPINION IN RHEUMATOLOGY

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know

(2016) Michael Aronov et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

(2016) Hung D. Nguyen et al.   JOURNAL OF CLINICAL INVESTIGATION

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells

(2016) Sinéad E. Keating et al.   JOURNAL OF IMMUNOLOGY

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

(2016) Katherine C. Verbist et al.   NATURE

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

(2016) Kristen N Pollizzi et al.   NATURE IMMUNOLOGY

Autophagy: controlling cell fate in rheumatic diseases

(2016) Jason S. Rockel et al.   Nature Reviews Rheumatology

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice

(2016) Zachary Oaks et al.   Arthritis & Rheumatology

Novel Therapeutic Targets of Tumor Metabolism

(2015) Rigel J. Kishton et al.   CANCER JOURNAL

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses

(2015) J Arnold et al.   CELL DEATH AND DIFFERENTIATION

Dependence of Hippocampal Function on ERRγ-Regulated Mitochondrial Metabolism

(2015) Liming Pei et al.   Cell Metabolism

SnapShot: Immunometabolism

(2015) Peter J. Murray et al.   Cell Metabolism

ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency

(2015) Yasuyuki S. Kida et al.   Cell Stem Cell

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

(2015) Yi Bao et al.   JOURNAL OF CELL BIOLOGY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immune-Metabolic Basis of Effector Memory CD4+T Cell Function under Hypoxic Conditions

(2015) Sarah Dimeloe et al.   JOURNAL OF IMMUNOLOGY

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

What is damaging the kidney in lupus nephritis?

(2015) Anne Davidson   Nature Reviews Rheumatology

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

(2015) Monika Srivastava et al.   Nature Communications

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

(2015) Roybel R Ramiscal et al.   eLife

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased Mitochondrial Electron Transport Chain Activity at Complex I Is Regulated by N-Acetylcysteine in Lymphocytes of Patients with Systemic Lupus Erythematosus

(2014) Edward Doherty et al.   ANTIOXIDANTS & REDOX SIGNALING

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

The Peroxisome Proliferator-Activated Receptor   Agonist Rosiglitazone Ameliorates Murine Lupus by Induction of Adiponectin

(2014) T. Aprahamian et al.   JOURNAL OF IMMUNOLOGY

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

mTOR Activation Promotes Plasma Cell Differentiation and Bypasses XBP-1 for Immunoglobulin Secretion

(2014) Sandrine Benhamron et al.   MOLECULAR AND CELLULAR BIOLOGY

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake

(2014) Yoichi Maekawa et al.   NATURE MEDICINE

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Metabolic control of the epigenome in systemic Lupus erythematosus

(2013) Zachary Oaks et al.   AUTOIMMUNITY

Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions

(2013) P. P. C. Boor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus

(2013) Wenpu Zhao et al.   CLINICAL IMMUNOLOGY

Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus

(2013) Z.-W. Lai et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4+ T Cell Activation and Maps to Estrogen-Related Receptor  

(2012) D. J. Perry et al.   JOURNAL OF IMMUNOLOGY

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

(2011) Koutaro Ishibashi et al.   Autophagy

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

(2011) Lillian J. Eichner et al.   MITOCHONDRION

IFN-  and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells

(2011) H. Le Buanec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

(2011) E. Gatza et al.   Science Translational Medicine

Defective response of CD4+ T cells to retinoic acid and TGFβ in systemic lupus erythematosus

(2011) Eric S Sobel et al.   ARTHRITIS RESEARCH & THERAPY

Characterization of the metabolic phenotype of chronically activated lymphocytes

(2010) DR Wahl et al.   LUPUS

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation

(2009) Jeong-Ho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic control of T cell activation and death in SLE

(2008) David Fernandez et al.   AUTOIMMUNITY REVIEWS

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION