mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

(2015) Patricia Dillenburg-Pilla et al.   FASEB JOURNAL

Self-organization of protrusions and polarity during eukaryotic chemotaxis

(2014) Brian R Graziano et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondria Regulate Neutrophil Activation by Generating ATP for Autocrine Purinergic Signaling

(2014) Yi Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

(2014) Lunhua Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance

(2013) Z. Wu et al.   GENES & DEVELOPMENT

Pannexin 1 Channels Link Chemoattractant Receptor Signaling to Local Excitation and Global Inhibition Responses at the Front and Back of Polarized Neutrophils

(2013) Yi Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

Network Crosstalk Dynamically Changes during Neutrophil Polarization

(2012) Chin-Jen Ku et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

(2012) Qingsong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

(2012) Minsheng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL12 Uses CXCR4 and a Signaling Core Formed by Bifunctional Akt, Extracellular Signal-regulated Kinase (ERK)1/2, and Mammalian Target of Rapamycin Complex 1 (mTORC1) Proteins to Control Chemotaxis and Survival Simultaneously in Mature Dendritic Cells

(2011) Cristina Delgado-Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria

(2011) Vera C. Keil et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hyperoxia During Septic Shock—Dr. Jekyll or Mr. Hyde?

(2011) Pierre Asfar et al.   SHOCK

Dose-Related Effects of Hyperoxia on the Lung Inflammatory Response in Septic Rats

(2011) Dan Waisman et al.   SHOCK

A Comparison of Mathematical Models for Polarization of Single Eukaryotic Cells in Response to Guided Cues

(2011) Alexandra Jilkine et al.   PLoS Computational Biology

Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?

(2011) Andrey V Kozlov et al.   Annals of Intensive Care

The birth and postnatal development of purinergic signalling

(2010) G. Burnstock et al.   Acta Physiologica

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate Control of Host Centrosome Position, Organelle Distribution, and Migratory Response byToxoplasma gondiivia Host mTORC2

(2010) Yubao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction

(2010) M Colombi et al.   ONCOGENE

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury

(2009) Emmanuel Lorne et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis

(2009) F. Wang   Cold Spring Harbor Perspectives in Biology

Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine

(2008) Ross Corriden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY