Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies

Neuron-to-Neuron Transfer of FUS in Drosophila Primary Neuronal Culture Is Enhanced by ALS-Associated Mutations

(2017) Sébastien Feuillette et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Probing oligomerization of amyloid beta peptide in silico

(2017) L. Dorosh et al.   Molecular BioSystems

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Effect of Dye and Conjugation Chemistry on the Biodistribution Profile of Near-Infrared-Labeled Nanobodies as Tracers for Image-Guided Surgery

(2017) Pieterjan Debie et al.   MOLECULAR PHARMACEUTICS

Stop Alzheimer’s before it starts

(2017) Eric McDade et al.   NATURE

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells

(2017) Jan Stöhr et al.   Nature Chemistry

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

(2017) Eleanor K. Pickett et al.   SYNAPSE

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes

(2017) Shinsuke Ishigaki et al.   Cell Reports

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Alzheimer’s Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid

(2017) Rose Ann Huynh et al.   Frontiers in Neurology

Immunohistochemical Visualization of Amyloid-β Protein Precursor and Amyloid-β in Extra- and Intracellular Compartments in the Human Brain

(2017) Leena Aho et al.   JOURNAL OF ALZHEIMERS DISEASE

Single cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation

(2017) Sivan Peled et al.   Scientific Reports

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

(2017) Suzana Aulić et al.   Scientific Reports

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

(2016) Elisabeth Sanchez-Mejias et al.   ACTA NEUROPATHOLOGICA

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

(2016) Takayuki Oikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

(2016) Ye Jin Chai et al.   JOURNAL OF CELL BIOLOGY

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

(2016) Liviu-Gabriel Bodea et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels

(2016) D. Hefter et al.   JOURNAL OF NEUROSCIENCE

Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

(2016) Valentina Lacovich et al.   JOURNAL OF NEUROSCIENCE

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases

(2016) Gianluigi Forloni et al.   MOVEMENT DISORDERS

Failed Alzheimer’s trial does not kill leading theory of disease

(2016) Alison Abbott et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Ultrasound treatment of neurological diseases — current and emerging applications

(2016) Gerhard Leinenga et al.   Nature Reviews Neurology

In vitro prion-like behaviour of TDP-43 in ALS

(2016) Phillip Smethurst et al.   NEUROBIOLOGY OF DISEASE

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

(2016) Arne Ittner et al.   SCIENCE

Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus

(2016) Domenico Del Turco et al.   Frontiers in Molecular Neuroscience

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse

(2016) Sophia Schedin-Weiss et al.   Acta Neuropathologica Communications

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

(2016) Di Xia et al.   Scientific Reports

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

(2016) Zeyni Mansuroglu et al.   Scientific Reports

Fabrication of an antibody-aptamer sandwich assay for electrochemical evaluation of levels of β-amyloid oligomers

(2016) Yanli Zhou et al.   Scientific Reports

Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII

(2015) Yan Wei et al.   AGING CELL

Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study

(2015) Vincent Chouraki et al.   Alzheimers & Dementia

CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study

(2015) Michael Ewers et al.   Alzheimers & Dementia

Heterogeneity and Turnover of Intermediates during Amyloid-β (Aβ) Peptide Aggregation Studied by Fluorescence Correlation Spectroscopy

(2015) Ann Tiiman et al.   BIOCHEMISTRY

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines

(2015) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

Spatial Intensity Distribution Analysis Reveals Abnormal Oligomerization of Proteins in Single Cells

(2015) Antoine G. Godin et al.   BIOPHYSICAL JOURNAL

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide

(2015) Christine C. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Cooperative Roles of Hydrophilic Loop 1 and the C-Terminus of Presenilin 1 in the Substrate-Gating Mechanism of  -Secretase

(2015) S. Takagi-Niidome et al.   JOURNAL OF NEUROSCIENCE

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

(2015) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD

(2015) P. Regan et al.   JOURNAL OF NEUROSCIENCE

Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

(2015) Pritam Ganguly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

(2015) Emily D. Niederst et al.   MOLECULAR BIOLOGY OF THE CELL

Huntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin

(2015) Z Tan et al.   MOLECULAR PSYCHIATRY

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Transcellular spreading of huntingtin aggregates in theDrosophilabrain

(2015) Daniel T. Babcock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP

(2015) Grant T. Corbett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model

(2015) Gerhard Leinenga et al.   Science Translational Medicine

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

(2015) Yoshiyuki Soeda et al.   Nature Communications

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS

(2015) Rosa Pujol-Pina et al.   Scientific Reports

A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast

(2015) Genrikh V. Serpionov et al.   Scientific Reports

What we can learn from animal models about cerebral multi-morbidity

(2015) Siân Baker et al.   Alzheimers Research & Therapy

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

(2014) Brandon B. Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statistically quantified measurement of an Alzheimer's marker by surface-enhanced Raman scattering

(2014) Ričardas Buividas et al.   Journal of Biophotonics

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Differential Release of  -Amyloid from Dendrite- Versus Axon-Targeted APP

(2014) S. R. DeBoer et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

(2014) M. L. Frandemiche et al.   JOURNAL OF NEUROSCIENCE

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Loss of MAP Function Leads to Hippocampal Synapse Loss and Deficits in the Morris Water Maze with Aging

(2014) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Differential role of APP and APLPs for neuromuscular synaptic morphology and function

(2014) Maja Klevanski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

(2014) Alberto Lleó et al.   Nature Reviews Neurology

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

(2014) Jakob Domert et al.   NEUROBIOLOGY OF DISEASE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

(2014) Kunihiko Kanatsu et al.   Nature Communications

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

(2014) Linda Lee et al.   Scientific Reports

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Increased Polyubiquitination and Proteasomal Degradation of a Munc18-1 Disease-Linked Mutant Causes Temperature-Sensitive Defect in Exocytosis

(2014) Sally Martin et al.   Cell Reports

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

(2014) Joshua HK Tam et al.   Molecular Brain

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

(2013) Manuela Polydoro et al.   ACTA NEUROPATHOLOGICA

Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease

(2013) Alan Rembach et al.   Alzheimers & Dementia

Heme Binding Induces Dimerization and Nitration of Truncated β-Amyloid Peptide Aβ16 Under Oxidative Stress

(2013) Grégory Thiabaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease

(2013) Paula Merino-Serrais et al.   BRAIN

The dendritic hypothesis for Alzheimer's disease pathophysiology

(2013) J. Nicholas Cochran et al.   BRAIN RESEARCH BULLETIN

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

(2013) Jessica F. Jordão et al.   EXPERIMENTAL NEUROLOGY

Redundancy and divergence in the amyloid precursor protein family

(2013) S. Ali M. Shariati et al.   FEBS LETTERS

Binding of Apolipoprotein E Inhibits the Oligomer Growth of Amyloid-β Peptide in Solution as Determined by Fluorescence Cross-correlation Spectroscopy

(2013) Sonny Ly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer’s disease pathogenic factor

(2013) Chang-Beom Kim et al.   JOURNAL OF BIOMEDICAL OPTICS

PTL-1 regulates neuronal integrity and lifespan in C. elegans

(2013) Y. L. Chew et al.   JOURNAL OF CELL SCIENCE

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

(2013) G. Amadoro et al.   NEUROBIOLOGY OF DISEASE

Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI

(2013) S. J. B. Vos et al.   NEUROLOGY

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Investigating Interventions in Alzheimer's Disease with Computer Simulation Models

(2013) Carole J. Proctor et al.   PLoS One

Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus

(2013) Chang Liu et al.   PLoS One

A closer look at prion strains

(2013) Laura Solforosi et al.   Prion

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

(2013) Takashi Nonaka et al.   Cell Reports

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Expression and function of APP and its metabolites outside the central nervous system

(2012) Kendra L. Puig et al.   EXPERIMENTAL GERONTOLOGY

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes

(2012) Sathish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies

(2012) Connie Luk et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography

(2012) David A Wolk et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of  -Amyloid

(2012) S. Nath et al.   JOURNAL OF NEUROSCIENCE

Label-Free Imaging of Cerebral  -Amyloidosis with Extended-Focus Optical Coherence Microscopy

(2012) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

(2012) Christopher M Clark et al.   LANCET NEUROLOGY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

(2012) Xuejing Li et al.   NEUROBIOLOGY OF DISEASE

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

(2011) Stefani N. Thomas et al.   ACTA NEUROPATHOLOGICA

Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease

(2011) Juan F. Reyes et al.   AMERICAN JOURNAL OF PATHOLOGY

The unfolded protein response and proteostasis in Alzheimer disease

(2011) Wiep Scheper et al.   Autophagy

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

(2011) Alessia Usardi et al.   FEBS Journal

A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions

(2011) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitive and specific detection of sporadic Creutzfeldt-Jakob disease brain prion protein using real-time quaking-induced conversion

(2011) A. H. Peden et al.   JOURNAL OF GENERAL VIROLOGY

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

(2011) Rebecca F. Rosen et al.   JOURNAL OF NEUROCHEMISTRY

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-  Immunotherapy

(2011) A. Wang et al.   JOURNAL OF NEUROSCIENCE

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A  Is Induced by Pyroglutamate-A  Formation

(2011) A. Alexandru et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid  -peptides in human cerebrospinal fluid

(2011) A. Halim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging

(2011) Donat Kögel et al.   EXPERIMENTAL BRAIN RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

(2010) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

(2009) Oliver Wirths et al.   ACTA NEUROPATHOLOGICA

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Animal models reveal role for tau phosphorylation in human disease

(2009) Jürgen Götz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

(2009) Cindy M Sondag et al.   Journal of Neuroinflammation

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

APP Anterograde Transport Requires Rab3A GTPase Activity for Assembly of the Transport Vesicle

(2009) A. Szodorai et al.   JOURNAL OF NEUROSCIENCE

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

A novel pathway for amyloid precursor protein processing

(2009) Erik Portelius et al.   NEUROBIOLOGY OF AGING

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Goes Global

(2009) I. Bezprozvanny   Science Signaling

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Structure-Function Implications in Alzheimers Disease: Effect of Aβ Oligomers at Central Synapses

(2008) Waldo Cerpa et al.   Current Alzheimer Research

Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice

(2008) Anne Eckert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Detection of amyloid β protein in the urine of Alzheimer's disease patients and healthy individuals

(2008) Manabu Takata et al.   NEUROSCIENCE LETTERS

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

(2008) L. M. Ittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA