A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

(2016) Saoussen Ben Halima et al.   Cell Reports

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

(2015) Felix Jäckle et al.   BIOCHEMICAL JOURNAL

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

(2015) Kévin Baranger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human brain proteins showing neuron-specific interactions with γ-secretase

(2015) Mitsuhiro Inoue et al.   FEBS Journal

Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

(2015) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles

(2015) Gerhard Multhaup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

(2015) Heledd H. Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

(2015) Allen C. Chen et al.   JOURNAL OF CELL BIOLOGY

Synaptotagmins interact with APP and promote Aβ generation

(2015) Vivek Gautam et al.   Molecular Neurodegeneration

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice

(2015) Jeffrey L. Frost et al.   NEUROBIOLOGY OF AGING

Brain Amyloid-Beta Fragment Signatures in Pathological Ageing and Alzheimer's Disease by Hybrid Immunoprecipitation Mass Spectrometry

(2015) Erik Portelius et al.   Neurodegenerative Diseases

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

(2015) Junfeng Wang et al.   Nature Communications

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Quantitative Interaction Proteomics of Neurodegenerative Disease Proteins

(2015) Fabian Hosp et al.   Cell Reports

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

(2015) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease

(2014) Thomas A. Bayer et al.   ACTA NEUROPATHOLOGICA

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

(2014) Alfred T. Welzel et al.   BIOCHEMISTRY

CNS Amyloid- , Soluble APP-  and -  Kinetics during BACE Inhibition

(2014) J. A. Dobrowolska et al.   JOURNAL OF NEUROSCIENCE

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice

(2014) Apostolia Fragkouli et al.   NEUROBIOLOGY OF DISEASE

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

(2014) N Milosch et al.   Cell Death & Disease

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

(2014) Erik Portelius et al.   Alzheimers Research & Therapy

Systematic Evaluation of Candidate Ligands Regulating Ectodomain Shedding of Amyloid Precursor Protein

(2013) Heather C. Rice et al.   BIOCHEMISTRY

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis

(2013) Yu Deng et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Novel AβIsoforms in Alzheimer's Disease - Their Role in Diagnosis and Treatment

(2012) Erik Portelius et al.   CURRENT PHARMACEUTICAL DESIGN

Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments

(2012) Laura J. Vella et al.   FASEB JOURNAL

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

(2012) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Differential Effects between  -Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

(2012) Y. Mitani et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1

(2012) Bernhard M. Kohli et al.   JOURNAL OF PROTEOME RESEARCH

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

(2012) Julie Brodeur et al.   Molecular Neurodegeneration

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

(2012) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Membrane Trafficking Pathways in Alzheimer's Disease

(2012) Lawrence Rajendran et al.   TRAFFIC

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition

(2011) Xiangdong Zhou et al.   FASEB JOURNAL

Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells

(2011) Kristine K. Freude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

(2010) Christiane Reitz et al.   ANNALS OF NEUROLOGY

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Dual Role of α-Secretase Cleavage in the Regulation of γ-Secretase Activity for Amyloid Production

(2010) Yuan Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Transgenic Expression of the Amyloid-β Precursor Protein-Intracellular Domain Does Not Induce Alzheimer's Disease–Like Traits In Vivo

(2010) Luca Giliberto et al.   PLoS One

Truncated  -amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

(2010) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid

(2009) Erik Portelius et al.   EXPERIMENTAL NEUROLOGY

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

BRI3 Inhibits Amyloid Precursor Protein Processing in a Mechanistically Distinct Manner from Its Homologue Dementia Gene BRI2

(2009) Shuji Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Mint Proteins Decreases Amyloid Production in Transgenic Mouse Models of Alzheimer's Disease

(2009) A. Ho et al.   JOURNAL OF NEUROSCIENCE

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

CD74 interacts with APP and suppresses the production of Aβ

(2009) Shuji Matsuda et al.   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p3 peptide, a truncated form of Aβ devoid of synaptotoxic effect, does not assemble into soluble oligomers

(2008) Fabienne Dulin et al.   FEBS LETTERS

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRI2 Inhibits Amyloid  -Peptide Precursor Protein Processing by Interfering with the Docking of Secretases to the Substrate

(2008) S. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

(2008) Binggui Sun et al.   NEURON

The FE65 proteins and Alzheimer's disease

(2007) Declan M. McLoughlin et al.   JOURNAL OF NEUROSCIENCE RESEARCH