What we can learn from animal models about cerebral multi-morbidity

Connecting the dots between tau dysfunction and neurodegeneration

(2015) Bess Frost et al.   TRENDS IN CELL BIOLOGY

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

(2014) Tomohiro Umeda et al.   ACTA NEUROPATHOLOGICA

Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

(2014) Bidisha Roy et al.   HUMAN MOLECULAR GENETICS

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies

(2014) Cassia R Overk et al.   Molecular Neurodegeneration

Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy

(2013) Amy K. Clippinger et al.   ACTA NEUROPATHOLOGICA

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau

(2013) Ting-Han Wu et al.   ACTA NEUROPATHOLOGICA

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Neuropathological Correlates of Cerebral Multimorbidity

(2013) Johannes Attems et al.   Current Alzheimer Research

Modeling neurodegenerative diseases in Caenorhabditis elegans

(2013) Jia Li et al.   EXPERIMENTAL NEUROLOGY

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

(2013) Guilian Xu et al.   HUMAN MOLECULAR GENETICS

PTL-1 regulates neuronal integrity and lifespan in C. elegans

(2013) Y. L. Chew et al.   JOURNAL OF CELL SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Soluble  -Synuclein Is a Novel Modulator of Alzheimer's Disease Pathophysiology

(2012) M. E. Larson et al.   JOURNAL OF NEUROSCIENCE

Deciphering the mechanism underlying late-onset Alzheimer disease

(2012) Dimitrije Krstic et al.   Nature Reviews Neurology

Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice

(2012) Eliezer Masliah et al.   Prion

TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype

(2011) Yvonne S. Davidson et al.   ACTA NEUROPATHOLOGICA

Some evolutionary perspectives on Alzheimer’s disease pathogenesis and pathology

(2011) Daniel J. Glass et al.   Alzheimers & Dementia

Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio

(2011) Karen Schmitt et al.   ANTIOXIDANTS & REDOX SIGNALING

Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old

(2011) John L. Robinson et al.   BRAIN

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease

(2011) Thomas Haggerty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43

(2011) N. A. Lanson et al.   HUMAN MOLECULAR GENETICS

E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

(2011) Kristel L. Emmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span

(2011) Ji-Wu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

(2011) Jonathan Gilley et al.   NEUROBIOLOGY OF AGING

Studies of protein aggregation in A53T α-synuclein transgenic, Tg2576 transgenic, and P246L presenilin-1 knock-in cross bred mice

(2011) Kristel L. Emmer et al.   NEUROSCIENCE LETTERS

Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease

(2011) Meaghan Morris et al.   PLoS One

Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

(2010) Catherine M. Cowan et al.   ACTA NEUROPATHOLOGICA

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Differential Effects of Tau on the Integrity and Function of Neurons Essential for Learning in Drosophila

(2010) S. Kosmidis et al.   JOURNAL OF NEUROSCIENCE

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Aβ and human amylin share a common toxicity pathwayviamitochondrial dysfunction

(2010) Yun-An Lim et al.   PROTEOMICS

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease and natural cognitive aging may represent adaptive metabolism reduction programs

(2009) Jared Reser   Behavioral and Brain Functions

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

(2009) James Folwell et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

(2009) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

Role of Synucleins in Alzheimer’s Disease

(2009) Leslie Crews et al.   NEUROTOXICITY RESEARCH

Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice

(2008) Beatriz Caballero et al.   JOURNAL OF PINEAL RESEARCH

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

(2008) Igor F. Tsigelny et al.   PLoS One