Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns

DisGeNET-RDF: harnessing the innovative power of the Semantic Web to explore the genetic basis of diseases

(2016) Núria Queralt-Rosinach et al.   BIOINFORMATICS

Identifying compound efficacy targets in phenotypic drug discovery

(2016) Markus Schirle et al.   DRUG DISCOVERY TODAY

Hide and seek: Identification and confirmation of small molecule protein targets

(2015) Andrei Ursu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extending kinome coverage by analysis of kinase inhibitor broad profiling data

(2015) Edgar Jacoby et al.   DRUG DISCOVERY TODAY

The opportunities of mining historical and collective data in drug discovery

(2015) Anne Mai Wassermann et al.   DRUG DISCOVERY TODAY

The impact of CRISPR–Cas9 on target identification and validation

(2015) Jonathan D. Moore   DRUG DISCOVERY TODAY

Comprehensive characterization of the Published Kinase Inhibitor Set

(2015) Jonathan M Elkins et al.   NATURE BIOTECHNOLOGY

SureChEMBL: a large-scale, chemically annotated patent document database

(2015) George Papadatos et al.   NUCLEIC ACIDS RESEARCH

WikiPathways: capturing the full diversity of pathway knowledge

(2015) Martina Kutmon et al.   NUCLEIC ACIDS RESEARCH

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes

(2015) J. Pinero et al.   Database-The Journal of Biological Databases and Curation

Proteochemometric modelling coupled to in silico target prediction: an integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules

(2015) Shardul Paricharak et al.   Journal of Cheminformatics

A multi-label approach to target prediction taking ligand promiscuity into account

(2015) Avid M Afzal et al.   Journal of Cheminformatics

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

(2015) Jonathan A. Lee et al.   PLoS One

A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products

(2014) Anne Mai Wassermann et al.   ACS Chemical Biology

The EBI RDF platform: linked open data for the life sciences

(2014) S. Jupp et al.   BIOINFORMATICS

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4

(2014) Christian Schmitt et al.   ACS Medicinal Chemistry Letters

Phenotypic screening in the 21st century

(2014) Birgit T. Priest et al.   Frontiers in Pharmacology

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

(2013) D C Swinney   CLINICAL PHARMACOLOGY & THERAPEUTICS

The ChEMBL bioactivity database: an update

(2013) A. Patrícia Bento et al.   NUCLEIC ACIDS RESEARCH

The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells

(2012) Damiano Panelli et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Can we discover pharmacological promiscuity early in the drug discovery process?

(2012) Jens-Uwe Peters et al.   DRUG DISCOVERY TODAY

Open PHACTS: semantic interoperability for drug discovery

(2012) Antony J. Williams et al.   DRUG DISCOVERY TODAY

The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013

(2012) Janna Hastings et al.   NUCLEIC ACIDS RESEARCH

Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining

(2011) Tiejun Cheng et al.   Journal of Chemical Information and Modeling

From in silico target prediction to multi-target drug design: Current databases, methods and applications

(2011) Alexios Koutsoukas et al.   Journal of Proteomics

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

myExperiment: a repository and social network for the sharing of bioinformatics workflows

(2010) Carole A. Goble et al.   NUCLEIC ACIDS RESEARCH