Getting pharmaceutical R&D back on target

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

(2010) Laura De Luca et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

Activity-based probes: discovering new biology and new drug targets

(2010) William P. Heal et al.   CHEMICAL SOCIETY REVIEWS

Rational approaches to targeted polypharmacology: creating and navigating protein–ligand interaction networks

(2010) James T Metz et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mapping of pharmacological space

(2010) Britta Nisius et al.   Expert Opinion on Drug Discovery

Treatment of HIV infection with the CCR5 antagonist maraviroc

(2010) Wiete Kromdijk et al.   EXPERT OPINION ON PHARMACOTHERAPY

Small-molecule protein-protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

(2010) Peter Buchwald   IUBMB LIFE

Interactome under construction

(2010) Laura Bonetta   NATURE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Magic bullets in nature's arsenal

(2010) Joshua A Kritzer   Nature Chemical Biology

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Spending on new drug development

(2009) Christopher Paul Adams et al.   HEALTH ECONOMICS

An empirical framework for binary interactome mapping

(2008) Kavitha Venkatesan et al.   NATURE METHODS

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA