Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

(2010) Pernilla Örtqvist et al.   ANTIVIRAL THERAPY

Hepatitis C Virus: Assembly and Release of Virus Particles

(2010) Daniel M. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A

(2010) Helen Waller et al.   JOURNAL OF VIROLOGICAL METHODS

All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding

(2010) T. L. Foster et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins

(2010) J. Hwang et al.   JOURNAL OF VIROLOGY

Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial

(2010) Paul Y Kwo et al.   LANCET

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Telaprevir for Previously Treated Chronic HCV Infection

(2010) John G. McHutchison et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Domain 2 of the HCV NS5A Protein Is Intrinsically Unstructured

(2010) Xavier Hanoulle et al.   PROTEIN AND PEPTIDE LETTERS

Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus

(2010) L. Rong et al.   Science Translational Medicine

Quantification of Lipid Droplets and Associated Proteins in Cellular Models of Obesity via High-Content/High-Throughput Microscopy and Automated Image Analysis

(2009) Patrick M. McDonough et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded

(2009) Xavier Hanoulle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

(2009) M. Hughes et al.   JOURNAL OF GENERAL VIROLOGY

Identification of Hepatitis C Virus NS5A Inhibitors

(2009) J. A. Lemm et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

The global burden of hepatitis C

(2009) Daniel Lavanchy   LIVER INTERNATIONAL

Telaprevir for Chronic HCV Infection

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir and Peginterferon with or without Ribavirin for Chronic HCV Infection

(2009) Christophe Hézode et al.   NEW ENGLAND JOURNAL OF MEDICINE

Telaprevir with Peginterferon and Ribavirin for Chronic HCV Genotype 1 Infection

(2009) John G. McHutchison et al.   NEW ENGLAND JOURNAL OF MEDICINE

HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity In Vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus

(2008) Norman M. Kneteman et al.   HEPATOLOGY

Maturation of Hepatitis C Virus Core Protein by Signal Peptide Peptidase Is Required for Virus Production

(2008) Paul Targett-Adams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dynamic View of Hepatitis C Virus Replication Complexes

(2008) B. Wolk et al.   JOURNAL OF VIROLOGY

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

(2008) T. Masaki et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule- and Dynein-Dependent Manner

(2008) Steeve Boulant et al.   TRAFFIC

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

(2008) Timothy L. Tellinghuisen et al.   PLoS Pathogens