A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Dragging Ras Back in the Ring

(2014) Andrew G. Stephen et al.   CANCER CELL

Sorting out the trash: the spatial nature of eukaryotic protein quality control

(2014) Emily M Sontag et al.   CURRENT OPINION IN CELL BIOLOGY

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

(2014) Lesley A. Mathews Griner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes

(2013) Julie C. Friedland et al.   INVESTIGATIONAL NEW DRUGS

Targeted Degradation of KRAS by an Engineered Ubiquitin Ligase Suppresses Pancreatic Cancer Cell Growth In Vitro and In Vivo

(2013) Y. Ma et al.   MOLECULAR CANCER THERAPEUTICS

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Mutant KRAS is a druggable target for pancreatic cancer

(2013) E. Zorde Khvalevsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

(2012) Qi Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis

(2012) Yilin Huo et al.   BIOCHEMICAL JOURNAL

Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins

(2012) Kwang-jin Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission

(2012) D. van der Hoeven et al.   MOLECULAR AND CELLULAR BIOLOGY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of Oncogenic KRAS in Non-Small Cell Lung Cancers Suppresses Tumor Growth and Sensitizes Tumor Cells to Targeted Therapy

(2011) N. Sunaga et al.   MOLECULAR CANCER THERAPEUTICS

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

(2011) Kristen L. Meerbrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets

(2010) Marian Grade et al.   INTERNATIONAL JOURNAL OF CANCER

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

(2010) Fumi Shima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Inducers of Targeted Protein Degradation

(2010) Kanak Raina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

(2009) Thomas O'Hare et al.   CANCER CELL

PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers

(2009) S. Wee et al.   CANCER RESEARCH

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

(2008) A Rodriguez-Gonzalez et al.   ONCOGENE