TAK1 Inhibition in the DFG-Out Conformation

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol

(2012) Jiaquan Wu et al.   ACS Chemical Biology

TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers

(2012) Anurag Singh et al.   CELL

Identification of Type-II Inhibitors Using Kinase Structures

(2012) Frank Lovering et al.   Chemical Biology & Drug Design

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

(2012) Pam Albaugh et al.   ACS Medicinal Chemistry Letters

Oxindole derivatives as inhibitors of TAK1 kinase

(2011) Jeffrey W. Lockman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease

(2011) David S. Millan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced selectivity profile of pyrazole-urea based DFG-out p38α inhibitors

(2010) Hu Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical probing reveals insights into the signaling mechanism of inflammasome activation

(2010) Yi-Nan Gong et al.   CELL RESEARCH

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases

(2009) Rajamalleswaramma Jogireddy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Searching Chemical Space with the Bayesian Idea Generator

(2009) Willem P. van Hoorn et al.   Journal of Chemical Information and Modeling

Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

(2009) Fabio Zuccotto et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAK1-Mediated Serine/Threonine Phosphorylation of Epidermal Growth Factor Receptor via p38/Extracellular Signal-Regulated Kinase: NF- B-Independent Survival Pathways in Tumor Necrosis Factor Alpha Signaling

(2009) M. Nishimura et al.   MOLECULAR AND CELLULAR BIOLOGY

Epoxyquinol B, a Naturally Occurring Pentaketide Dimer, Inhibits NF-κB Signaling by Crosslinking TAK1

(2008) Hiroshi KAMIYAMA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY