Identification of false positives in “HTS hits to lead”: The application of Bayesian models in HTS triage to rapidly deliver a series of selective TRPV4 antagonists

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

(2011) Christopher E. Keefer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification and Characterization of mGlu3 Ligands Using a High Throughput FLIPR Assay for Detection of Agonists, Antagonists, and Allosteric Modulators

(2011) Steven D. Pratt et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

SAR mining and its application to the design of TRPA1 antagonists

(2011) James E. J. Mills et al.   MedChemComm

Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

(2009) Thomas Ryckmans et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enhanced HTS Hit Selection via a Local Hit Rate Analysis

(2009) Bruce A. Posner et al.   Journal of Chemical Information and Modeling

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2

(2008) R. N. Willette et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS