Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Mechanisms of Coronary Thrombosis in Cigarette Smoke Exposure

(2013) Rajat S. Barua et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality

(2013) Matias S. Attene-Ramos et al.   DRUG DISCOVERY TODAY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A Computational Model Predicting Disruption of Blood Vessel Development

(2013) Nicole Kleinstreuer et al.   PLoS Computational Biology

Complex effects of 17β-estradiol on mitochondrial function

(2012) Anika Thiede et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of Tissue Factor in Atherothrombosis

(2012) A. Phillip Owens et al.   Current Atherosclerosis Reports

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

Essentials of the self-organizing map

(2012) Teuvo Kohonen   NEURAL NETWORKS

Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1

(2011) Matthew T Martin et al.   BIOLOGY OF REPRODUCTION

Environmental Impact on Vascular Development Predicted by High-Throughput Screening

(2011) Nicole C. Kleinstreuer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Possible involvement of serotonin 5-HT2 receptor in the regulation of feeding behavior through the histaminergic system

(2011) Tomotaka Murotani et al.   NEUROPHARMACOLOGY

Multiple effects of a short-term dexamethasone treatment in human skeletal muscle and adipose tissue

(2011) Nathalie Viguerie et al.   PHYSIOLOGICAL GENOMICS

Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

(2011) Nisha S. Sipes et al.   TOXICOLOGICAL SCIENCES

Tissue distribution of 35S-labelled perfluorooctane sulfonate in adult mice after oral exposure to a low environmentally relevant dose or a high experimental dose

(2011) Jasna Bogdanska et al.   TOXICOLOGY

Discovery of Dual Inhibitors of the Immune Cell PI3Ks p110δ and p110γ: a Prototype for New Anti-inflammatory Drugs

(2010) Olusegun Williams et al.   CHEMISTRY & BIOLOGY

Changes of AMPA receptors in MPTP monkeys with levodopa-induced dyskinesias

(2010) B. Ouattara et al.   NEUROSCIENCE

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

(2010) Fiona E McCann et al.   ARTHRITIS RESEARCH & THERAPY

Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

(2009) Stanley B. Cohen et al.   ARTHRITIS AND RHEUMATISM

Statins and angiogenesis: Is it about connections?

(2009) Magomed Khaidakov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents

(2009) G. G. Camici et al.   EUROPEAN HEART JOURNAL

Molecular docking and ligand specificity in fragment-based inhibitor discovery

(2009) Yu Chen et al.   Nature Chemical Biology

Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge

(2009) Matthew J. Fell et al.   NEUROPHARMACOLOGY

Chemical target and pathway toxicity mechanisms defined in primary human cell systems

(2009) Ellen L. Berg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Toxicity Data Landscape for Environmental Chemicals

(2008) Richard Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Understanding mechanisms of toxicity: Insights from drug discovery research

(2007) Keith A. Houck et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY