EMT- and MET-related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia

(2016) Hubo Li et al.   BLOOD

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome

(2016) Vaia Stavropoulou et al.   CANCER CELL

Temozolomide promotes genomic and phenotypic changes in glioblastoma cells

(2016) Aleksei A. Stepanenko et al.   Cancer Cell International

Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-κB pathway and epithelial-mesenchymal transition

(2016) Z.M. Feng et al.   GENETICS AND MOLECULAR RESEARCH

Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways

(2016) U.D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

A Long Noncoding RNA ZEB1-AS1 Promotes Tumorigenesis and Predicts Poor Prognosis in Glioma

(2016) Qiao-Li Lv et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

(2016) Menggui Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Diagnostic and predictive biomarkers for lymphoma diagnosis and treatment in the era of precision medicine

(2016) Ruifang Sun et al.   MODERN PATHOLOGY

Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2

(2016) Jason A. Somarelli et al.   MOLECULAR AND CELLULAR BIOLOGY

Anthocyanidins inhibit epithelial-mesenchymal transition through a TGFβ/Smad2 signaling pathway in glioblastoma cells

(2016) Amira Ouanouki et al.   MOLECULAR CARCINOGENESIS

High nuclear expression of Twist1 in the skeletal extramedullary disease of myeloma patients predicts inferior survival

(2016) Jian-Zhu Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells

(2016) M Drachsler et al.   Cell Death & Disease

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

(2016) C. Depner et al.   Nature Communications

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

(2016) A. Mishra et al.   Cancer Discovery

Estrogen-related receptor α participates transforming growth factor-β (TGF-β) induced epithelial-mesenchymal transition of osteosarcoma cells

(2016) Yantao Chen et al.   Cell Adhesion & Migration

Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition

(2016) Shalini Singh et al.   eLife

Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma

(2016) Teresia Kling et al.   EBioMedicine

Kukoamine A inhibits human glioblastoma cell growth and migration through apoptosis induction and epithelial-mesenchymal transition attenuation

(2016) Qiaoping Wang et al.   Scientific Reports

Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

(2015) David Castel et al.   ACTA NEUROPATHOLOGICA

MIR517Cinhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation

(2015) Yuntao Lu et al.   Autophagy

Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway

(2015) Yunhong Tian et al.   BMC CANCER

ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres

(2015) Ulf D. Kahlert et al.   BRAIN PATHOLOGY

Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells

(2015) M Ricciardi et al.   BRITISH JOURNAL OF CANCER

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis

(2015) Justin V. Joseph et al.   CANCER LETTERS

Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor

(2015) Zhongyong Wang et al.   CURRENT PHARMACEUTICAL DESIGN

The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links

(2015) Xiangqiang Liu et al.   CURRENT PHARMACEUTICAL DESIGN

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3 , GATA6 , and TWIST1 in the Sezary Syndrome

(2015) Henry K. Wong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes

(2015) Linghua Wang et al.   NATURE GENETICS

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Secreted Frizzled-Related Protein 4 Inhibits Glioma Stem-Like Cells by Reversing Epithelial to Mesenchymal Transition, Inducing Apoptosis and Decreasing Cancer Stem Cell Properties

(2015) Bhuvanalakshmi G et al.   PLoS One

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Favorable clinical outcome and unique characteristics in association with Twist1 overexpression in de novo acute myeloid leukemia

(2015) C-C Chen et al.   Blood Cancer Journal

Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells

(2015) Elena Ciaglia et al.   Oncotarget

Transforming growth factor-β pathway activity in glioblastoma

(2015) Karl Frei et al.   Oncotarget

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

(2015) Hui Xu et al.   Oncotarget

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

(2015) Ran Duan et al.   Oncotarget

TWIST-1 promotes cell growth, drug resistance and progenitor clonogenic capacities in myeloid leukemia and is a novel poor prognostic factor in acute myeloid leukemia

(2015) Nan Wang et al.   Oncotarget

HOTAIR is a therapeutic target in glioblastoma

(2015) Xuan Zhou et al.   Oncotarget

Epigenetic treatment of solid tumours: a review of clinical trials

(2015) Clara Nervi et al.   Clinical Epigenetics

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Down-Regulated E-Cadherin Expression Is Associated with Poor Five-Year Overall Survival in Bone and Soft Tissue Sarcoma: Results of a Meta-Analysis

(2015) Ning Wang et al.   PLoS One

LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program

(2015) Xing-gang Mao et al.   Oncotarget

A radiosensitivity gene signature in predicting glioma prognostic via EMT pathway

(2015) Jin Meng et al.   Oncotarget

Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior

(2014) Wei-Ting Huang et al.   MODERN PATHOLOGY

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

Periostin is a novel therapeutic target that predicts and regulates glioma malignancy

(2014) Andrei M. Mikheev et al.   NEURO-ONCOLOGY

Regulation of p21 by TWIST2 contributes to its tumor-suppressor function in human acute myeloid leukemia

(2014) X Zhang et al.   ONCOGENE

IL-17/miR-192/IL-17Rs Regulatory Feedback Loop Facilitates Multiple Myeloma Progression

(2014) Yuanyuan Sun et al.   PLoS One

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

(2014) J V Joseph et al.   Cell Death & Disease

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia

(2014) Stefano Percio et al.   Genome Medicine

MicroRNAs in Soft Tissue Sarcomas: Overview of the Accumulating Evidence and Importance as Novel Biomarkers

(2014) Tomohiro Fujiwara et al.   Biomed Research International

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

(2014) Yarden Katz et al.   eLife

Snail1 Expression Is Required for Sarcomagenesis

(2014) Lorena Alba-Castellón et al.   NEOPLASIA

The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma

(2013) E Sánchez-Tilló et al.   CELL DEATH AND DIFFERENTIATION

Acquired Resistance to Anti-VEGF Therapy in Glioblastoma Is Associated with a Mesenchymal Transition

(2013) Y. Piao et al.   CLINICAL CANCER RESEARCH

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Down Regulation of miR200c Promotes Radiation-Induced Thymic Lymphoma by Targeting BMI1

(2013) Jianguo Cui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

STAT3 silencing inhibits glioma single cell infiltration and tumor growth

(2013) M. Priester et al.   NEURO-ONCOLOGY

NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200

(2013) J. Fu et al.   NEURO-ONCOLOGY

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

(2013) Roshan Mahabir et al.   NEURO-ONCOLOGY

Snail depletes the tumorigenic potential of glioblastoma

(2013) K Savary et al.   ONCOGENE

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNAs link metabolic reprogramming to oncogenesis

(2013) Maria Hatziapostolou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma

(2012) Lee A.D. Cooper et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β as a therapeutic target in high grade gliomas – Promises and challenges

(2012) Justin V. Joseph et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Transcriptional Factors for Epithelial-Mesenchymal Transition Are Associated with Mesenchymal Differentiation in Gliosarcoma

(2012) Masaya Nagaishi et al.   BRAIN PATHOLOGY

Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition

(2012) Ulf D. Kahlert et al.   CANCER LETTERS

Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma

(2012) Siria Lemma et al.   HISTOPATHOLOGY

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

A Systematic Review of MicroRNA in Glioblastoma Multiforme: Micro-modulators in the Mesenchymal Mode of Migration and Invasion

(2012) Heidi G. Møller et al.   MOLECULAR NEUROBIOLOGY

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

(2012) Y. Piao et al.   NEURO-ONCOLOGY

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

(2012) Stephanie Puget et al.   PLoS One

ZEB2 Mediates Multiple Pathways Regulating Cell Proliferation, Migration, Invasion, and Apoptosis in Glioma

(2012) Songtao Qi et al.   PLoS One

The epithelial–mesenchymal transition under control: Global programs to regulate epithelial plasticity

(2012) M. Angela Nieto et al.   SEMINARS IN CANCER BIOLOGY

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog-Induced Transformation of Neural Cells

(2011) L. E. C. Wanshura et al.   CANCER RESEARCH

Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation

(2011) X. Jin et al.   CANCER RESEARCH

SNAI1 is Involved in the Proliferation and Migration of Glioblastoma Cells

(2011) Sung-Pil Han et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Aberrant expression of the transcriptional factor Twist1 promotes invasiveness in ALK-positive anaplastic large cell lymphoma

(2011) Jingdong Zhang et al.   CELLULAR SIGNALLING

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity

(2011) S. H. Thathia et al.   HAEMATOLOGICA

Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma

(2011) Aidong Shen et al.   JOURNAL OF SURGICAL ONCOLOGY

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus

(2010) Vasiliki Papadopoulou et al.   BIOCHEMICAL JOURNAL

Deregulation of TWIST-1 in the CD34+ compartment represents a novel prognostic factor in chronic myeloid leukemia

(2010) E. Cosset et al.   BLOOD

Silencing of Autocrine Motility Factor Induces Mesenchymal-to-Epithelial Transition and Suppression of Osteosarcoma Pulmonary Metastasis

(2010) Y. Niinaka et al.   CANCER RESEARCH

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Proteomics and Genomics Analysis Reveals a Novel Mesenchymal to Epithelial Reverting Transition in Leiomyosarcoma through Regulation of Slug

(2010) Jilong Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

(2010) Svetlana A Mikheeva et al.   Molecular Cancer

Sonic Hedgehog/GLI1 signaling pathway inhibition restricts cell migration and invasion in human gliomas

(2010) Ke Wang et al.   NEUROLOGICAL RESEARCH

Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-β1-mediated growth suppression in adult T-cell leukemia/lymphoma

(2010) S Nakahata et al.   ONCOGENE

Vimentin Is a Novel Anti-Cancer Therapeutic Target; Insights from In Vitro and In Vivo Mice Xenograft Studies

(2010) Guy Lahat et al.   PLoS One

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

A Mesenchymal-Like ZEB1+Niche Harbors Dorsal Radial Glial Fibrillary Acidic Protein-Positive Stem Cells in the Spinal Cord

(2009) Jean-Charles Sabourin et al.   STEM CELLS

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Sarcoma Epidemiology and Etiology: Potential Environmental and Genetic Factors

(2008) Guy Lahat et al.   SURGICAL CLINICS OF NORTH AMERICA