Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

Three Paths to Better Tyrosine Kinase Inhibition Behind the Blood-Brain Barrier in Treating Chronic Myelogenous Leukemia and Glioblastoma with Imatinib

(2014) Richard E. Kast et al.   Translational Oncology

The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

(2011) Shwetal Mehta et al.   CANCER CELL

Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas

(2011) Hui-Qi Qu et al.   NEURO-ONCOLOGY

Clinical Relevance of Tumor Cells with Stem-Like Properties in Pediatric Brain Tumors

(2011) Cécile Thirant et al.   PLoS One

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

(2011) Liang Lei et al.   PLoS One

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

(2011) M. Monje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells

(2010) Fang Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

(2010) Juan L Garcia et al.   BMC CANCER

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

(2010) Jacqueline Kessler et al.   BMC CANCER

Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma

(2010) Alberto Broniscer et al.   CANCER

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma

(2010) O. J. Becher et al.   CANCER RESEARCH

Oncogenic BRAF Mutation with CDKN2A Inactivation Is Characteristic of a Subset of Pediatric Malignant Astrocytomas

(2010) J. D. Schiffman et al.   CANCER RESEARCH

IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group

(2010) Ian F. Pollack et al.   CHILDS NERVOUS SYSTEM

A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas

(2010) D. A. Bax et al.   CLINICAL CANCER RESEARCH

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

(2010) T. Ozawa et al.   GENES & DEVELOPMENT

Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation

(2010) Kenta Masui et al.   GLIA

Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

(2010) Janna Paulsson et al.   INTERNATIONAL JOURNAL OF CANCER

Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets

(2010) Maryam Zarghooni et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

(2010) Barbara S. Paugh et al.   JOURNAL OF CLINICAL ONCOLOGY

An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients

(2010) François Ducray et al.   Molecular Cancer

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas

(2010) Jennifer Barrow et al.   NEURO-ONCOLOGY

Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

(2010) B. Geoerger et al.   NEURO-ONCOLOGY

Neuronal differentiation distinguishes supratentorial and infratentorial childhood ependymomas

(2010) F. Andreiuolo et al.   NEURO-ONCOLOGY

Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells

(2010) Y Wang et al.   ONCOGENE

Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent

(2010) J T Lucas et al.   ONCOGENE

The Proneural Molecular Signature Is Enriched in Oligodendrogliomas and Predicts Improved Survival among Diffuse Gliomas

(2010) Lee A. D. Cooper et al.   PLoS One

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression

(2010) C. D. Pozniak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outcome and prognostic features in pediatric gliomas

(2009) Ibrahim Qaddoumi et al.   CANCER

Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis

(2009) Thomas Palm et al.   CANCER

Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment

(2009) J. S. Lagas et al.   CLINICAL CANCER RESEARCH

EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines

(2009) D. A. Bax et al.   CLINICAL CANCER RESEARCH

Target-driven exploratory study of imatinib mesylate in children with solid malignancies by the Innovative Therapies for Children with Cancer (ITCC) European Consortium

(2009) Birgit Geoerger et al.   EUROPEAN JOURNAL OF CANCER

Prospective Evaluation of Radiotherapy With Concurrent and Adjuvant Temozolomide in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

(2009) Rakesh Jalali et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors

(2009) Qinghai Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme

(2009) Matthias Holdhoff et al.   JOURNAL OF NEURO-ONCOLOGY

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

(2009) N Lindberg et al.   ONCOGENE

Small molecule inhibitors in children with malignant gliomas

(2009) Betty Herrington et al.   PEDIATRIC BLOOD & CANCER

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

PDGF-B induces a homogeneous class of oligodendrogliomas from embryonic neural progenitors

(2008) Irene Appolloni et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas

(2008) Hideho Okada et al.   JOURNAL OF NEURO-ONCOLOGY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Oncogenic and ligand-dependent activation of KIT/PDGFRA in surgical samples of imatinib-treated gastrointestinal stromal tumours (GISTs)

(2008) T Negri et al.   JOURNAL OF PATHOLOGY

Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile

(2008) Francois Ducray et al.   Molecular Cancer