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Title
Therapeutic targeting of CK2 in acute and chronic leukemias
Authors
Keywords
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Journal
LEUKEMIA
Volume 32, Issue 1, Pages 1-10
Publisher
Springer Nature
Online
2017-09-27
DOI
10.1038/leu.2017.301
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Note: Only part of the references are listed.- Constitutive Phosphorylation of STAT3 by the CK2–BLNK–CD5 Complex
- (2017) Uri Rozovski et al. MOLECULAR CANCER RESEARCH
- Therapies on the horizon for childhood acute lymphoblastic leukemia
- (2016) William L. Carroll et al. CURRENT OPINION IN PEDIATRICS
- CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
- (2016) Haiwei Lian et al. HAEMATOLOGICA
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- (2016) Alice Melão et al. HAEMATOLOGICA
- Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia
- (2016) L Quotti Tubi et al. LEUKEMIA
- Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling
- (2016) S T Ribeiro et al. LEUKEMIA
- Targeting CK2-driven non-oncogene addiction in B-cell tumors
- (2016) E Mandato et al. ONCOGENE
- The role of proteasome inhibition in the treatment of malignant and non-malignant hematologic disorders
- (2016) Rebecca Citrin et al. Expert Review of Hematology
- High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement
- (2016) Zheng Ge et al. Oncotarget
- Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies
- (2016) Valentina Salizzato et al. Oncotarget
- CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
- (2016) Haiwei Lian et al. HAEMATOLOGICA
- Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity
- (2016) Alice Melão et al. HAEMATOLOGICA
- miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1
- (2016) Yi Zhang et al. Scientific Reports
- Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia
- (2016) Zheng Ge et al. Scientific Reports
- Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects
- (2015) Sofia Zanin et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia
- (2015) C. Song et al. BLOOD
- Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer
- (2015) M R Sarduy et al. BRITISH JOURNAL OF CANCER
- Ikaros and leukaemia
- (2015) Linda Olsson et al. BRITISH JOURNAL OF HAEMATOLOGY
- Transcriptional Regulation ofJARID1B/KDM5BHistone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia
- (2015) Haijun Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments
- (2015) Galina Schevzov et al. MOLECULAR BIOLOGY OF THE CELL
- Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia
- (2015) Zheng Ge et al. Oncotarget
- Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB
- (2015) Francesca Buontempo et al. Oncotarget
- Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor
- (2015) Leila R. Martins et al. Oncotarget
- Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells
- (2015) G.Kenneth Gray et al. Oncotarget
- Casein kinase: the triple meaning of a misnomer
- (2014) Andrea Venerando et al. BIOCHEMICAL JOURNAL
- Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels
- (2014) A. M. Gomes et al. HAEMATOLOGICA
- Ikaros fingers on lymphocyte differentiation
- (2014) Toshimi Yoshida et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (Review)
- (2014) CAMILLA EVANGELISTI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Protein Phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression ofTdTin thymocytes and T-cell leukemia
- (2014) Haijun Wang et al. PEDIATRIC BLOOD & CANCER
- Mining CK2 in Cancer
- (2014) Charina E. Ortega et al. PLoS One
- New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
- (2013) Eric C. Hales et al. CELLULAR SIGNALLING
- Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma
- (2013) Y. Zheng et al. CLINICAL CANCER RESEARCH
- Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity
- (2013) Laura Quotti Tubi et al. Journal of Hematology & Oncology
- Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia
- (2013) L R Martins et al. LEUKEMIA
- CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway
- (2013) R C Prins et al. LEUKEMIA
- Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling
- (2013) F Buontempo et al. LEUKEMIA
- Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: Biochemical evidence and therapeutic perspectives
- (2013) Christian Borgo et al. Molecular Oncology
- Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response
- (2012) Emmanuel Ampofo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Acute myelogenous leukemia stem cells: From Bench to Bedside
- (2012) J. Felipe Rico et al. CANCER LETTERS
- CK2 regulates ATF4 and CHOP transcription within the cellular stress response signalling pathway
- (2012) Carolin C. Schneider et al. CELLULAR SIGNALLING
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- (2012) Lori S. Hart et al. JOURNAL OF CLINICAL INVESTIGATION
- CD5-Dependent CK2 Activation Pathway Regulates Threshold for T Cell Anergy
- (2012) C. M. Sestero et al. JOURNAL OF IMMUNOLOGY
- Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways
- (2012) F Piazza et al. LEUKEMIA
- A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway
- (2011) Y. Zheng et al. BLOOD
- IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias
- (2011) A. Silva et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
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- (2011) Maria Ruzzene et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research
- (2011) Silvio E. Perea et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
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- (2011) J. S. Duncan et al. Science Signaling
- Emergence of protein kinase CK2 as a key target in cancer therapy
- (2010) Janeen H. Trembley et al. BIOFACTORS
- Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia
- (2010) L. R. Martins et al. BLOOD
- STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
- (2010) I. Hazan-Halevy et al. BLOOD
- CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy
- (2010) A. Siddiqui-Jain et al. CANCER RESEARCH
- Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies
- (2009) Ana M Solares et al. BMC CANCER
- Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells
- (2009) Giovanni Di Maira et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Protein Kinase CK2 in Health and Disease
- (2009) J. H. Trembley et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli
- (2009) Miranda L. Cox et al. CELLULAR SIGNALLING
- Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and -secretase inhibitors
- (2009) A. Silva et al. HAEMATOLOGICA
- The selectivity of inhibitors of protein kinase CK2: an update
- (2008) Mario A. Pagano et al. BIOCHEMICAL JOURNAL
- PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
- (2008) Ana Silva et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
- (2008) J A McCubrey et al. LEUKEMIA
- Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia
- (2008) L S Steelman et al. LEUKEMIA
- CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo
- (2008) Silvio E. Perea et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
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