Casein kinase: the triple meaning of a misnomer

Active Form of the Protein Kinase CK2 α2β2 Holoenzyme Is a Strong Complex with Symmetric Architecture

(2013) Graziano Lolli et al.   ACS Chemical Biology

Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

(2013) Najma Rachidi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic characterization of CK2 inhibitor CX-4945

(2013) You Hwa Son et al.   ARCHIVES OF PHARMACAL RESEARCH

Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation

(2013) Andrea Venerando et al.   BIOCHEMICAL JOURNAL

Wnt/β-catenin signalling: from plasma membrane to nucleus

(2013) Wantae Kim et al.   BIOCHEMICAL JOURNAL

Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: Applications to protein kinase CK2

(2013) Laszlo Gyenis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Unwinding the Wnt action of casein kinase 1

(2013) Daniel GR Yim et al.   CELL RESEARCH

Targeting Protein Kinase CK2 Suppresses Prosurvival Signaling Pathways and Growth of Glioblastoma

(2013) Y. Zheng et al.   CLINICAL CANCER RESEARCH

Kinase CK2 Inhibition: An Update

(2013) G. Cozza et al.   CURRENT MEDICINAL CHEMISTRY

Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification

(2013) Silje Hjorth Rafaelsen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

(2013) L R Martins et al.   LEUKEMIA

CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway

(2013) R C Prins et al.   LEUKEMIA

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

(2013) F Buontempo et al.   LEUKEMIA

The Casein Kinase 2-Nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression

(2013) Yoshiki Tsuchiya et al.   MOLECULAR AND CELLULAR BIOLOGY

Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: Biochemical evidence and therapeutic perspectives

(2013) Christian Borgo et al.   Molecular Oncology

pLogo: a probabilistic approach to visualizing sequence motifs

(2013) Joseph P O'Shea et al.   NATURE METHODS

Nephrocalcinosis (Enamel Renal Syndrome) Caused by Autosomal RecessiveFAM20AMutations

(2013) Graciana Jaureguiberry et al.   NEPHRON PHYSIOLOGY

Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

(2013) Sabrina Manni et al.   PLoS One

Crystal structure of the Golgi casein kinase

(2013) J. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA

(2013) L. X. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

Global Screening of CK2 Kinase Substrates by an Integrated Phosphoproteomics Workflow

(2013) Yangyang Bian et al.   Scientific Reports

FAM20A Mutations Can Cause Enamel-Renal Syndrome (ERS)

(2013) Shih-Kai Wang et al.   PLoS Genetics

Structural Determinants of Protein Kinase CK2 Regulation by Autoinhibitory Polymerization

(2012) Graziano Lolli et al.   ACS Chemical Biology

Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants

(2012) Mauro Salvi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Protein Kinase CK2 by Flavonoids and Tyrphostins. A Structural Insight

(2012) Graziano Lolli et al.   BIOCHEMISTRY

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

(2012) Joshua Bliesath et al.   CANCER LETTERS

Protein Kinase CK1α Regulates Erythrocyte Survival

(2012) Christine Zelenak et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress-Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response

(2012) S. Manni et al.   CLINICAL CANCER RESEARCH

Protein kinase CK2 inhibitors: a patent review

(2012) Giorgio Cozza et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

FAM20C Plays an Essential Role in the Formation of Murine Teeth

(2012) Xiaofang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitivity of tumor cells towards CIGB-300 anticancer peptide relies on its nucleolar localization

(2012) Yasser Perera et al.   JOURNAL OF PEPTIDE SCIENCE

Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2

(2012) Laszlo Gyenis et al.   Journal of Proteomics

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction

(2012) A Deshiere et al.   ONCOGENE

Impaired CK1 Delta Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo

(2012) Heidrun Hirner et al.   PLoS One

Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells

(2012) Toru Hosoi et al.   PLoS One

Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells

(2012) Sofia Zanin et al.   PLoS One

AtaA, a New Member of the Trimeric Autotransporter Adhesins from Acinetobacter sp. Tol 5 Mediating High Adhesiveness to Various Abiotic Surfaces

(2012) Masahito Ishikawa et al.   PLoS One

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization

(2012) V. S. Tagliabracci et al.   SCIENCE

Secreted protein kinases

(2012) Vincent S. Tagliabracci et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amelogenesis Imperfecta and Other Biomineralization Defects in Fam20a and Fam20c Null Mice

(2012) P. Vogel et al.   VETERINARY PATHOLOGY

Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice

(2012) Xiaofang Wang et al.   PLoS Genetics

Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome

(2011) James O'Sullivan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β

(2011) Miles C. Smith et al.   ANTIVIRAL RESEARCH

Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells

(2011) Janeen H. Trembley et al.   CANCER LETTERS

The SCPP Gene Family and the Complexity of Hard Tissues in Vertebrates

(2011) Kazuhiko Kawasaki   CELLS TISSUES ORGANS

ATP Site-Directed Inhibitors of Protein Kinase CK2: An Update

(2011) S. Sarno et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

CIGB-300, a proapoptotic peptide, inhibits angiogenesis in vitro and in vivo

(2011) Hernán G. Farina et al.   EXPERIMENTAL CELL RESEARCH

Novel FAM20A mutations in hypoplastic amelogenesis imperfecta

(2011) Sang Hyun Cho et al.   HUMAN MUTATION

Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

(2011) Naval P. Shanware et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CK2α is essential for embryonic morphogenesis

(2011) Isabel Dominguez et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice

(2011) Janeen H. Trembley et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protein kinase CK2 accumulation in “oncophilic” cells: causes and effects

(2011) Maria Ruzzene et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling

(2011) J. S. Duncan et al.   Science Signaling

Emergence of protein kinase CK2 as a key target in cancer therapy

(2010) Janeen H. Trembley et al.   BIOFACTORS

Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

(2010) R. Prudent et al.   CANCER RESEARCH

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

CK2 Modulation of NF- B, TP53, and the Malignant Phenotype in Head and Neck Cancer by Anti-CK2 Oligonucleotides In vitro or In vivo via Sub-50-nm Nanocapsules

(2010) M. S. Brown et al.   CLINICAL CANCER RESEARCH

Osteosclerotic bone dysplasia in siblings with a Fam20C mutation

(2010) M Fradin et al.   CLINICAL GENETICS

Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9

(2010) Elena Tibaldi et al.   FEBS LETTERS

Casein kinase 1: Complexity in the family

(2010) Jit Kong Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Casein   s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK

(2010) S. Vordenbaumen et al.   JOURNAL OF IMMUNOLOGY

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

(2010) Fabrice Pierre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Motif Analysis of Phosphosites Discloses a Potential Prominent Role of the Golgi Casein Kinase (GCK) in the Generation of Human Plasma Phospho-Proteome

(2010) Mauro Salvi et al.   JOURNAL OF PROTEOME RESEARCH

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

(2010) Daniel I. Perez et al.   MEDICINAL RESEARCH REVIEWS

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan–protein linkage region

(2009) Toshiyasu Koike et al.   BIOCHEMICAL JOURNAL

Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

(2009) Maria Ruzzene et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies

(2009) Ana M Solares et al.   BMC CANCER

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Isoform specific phosphorylation of p53 by protein kinase CK1

(2009) Andrea Venerando et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

(2009) Giovanni Di Maira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mutations in FAM20C also identified in non-lethal osteosclerotic bone dysplasia

(2009) MA Simpson et al.   CLINICAL GENETICS

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and  -secretase inhibitors

(2009) A. Silva et al.   HAEMATOLOGICA

Threonine 393 of β-catenin regulates interaction with Axin

(2009) Hao Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1α

(2009) Mauricio Budini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38α Mitogen Activated Protein Kinase and Casein Kinase 1δ†

(2009) Christian Peifer et al.   JOURNAL OF MEDICINAL CHEMISTRY

CK2 Is a Novel Negative Regulator of NADPH Oxidase and a Neuroprotectant in Mice after Cerebral Ischemia

(2009) G. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Selective Inhibition of Casein Kinase 1  Minimally Alters Circadian Clock Period

(2009) K. M. Walton et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anticancer peptide CIGB-300 binds to nucleophosmin/B23, impairs its CK2-mediated phosphorylation, and leads to apoptosis through its nucleolar disassembly activity

(2009) Y. Perera et al.   MOLECULAR CANCER THERAPEUTICS

The flaviviral methyltransferase is a substrate of Casein Kinase 1

(2009) Dipankar Bhattacharya et al.   VIRUS RESEARCH

Identification of novel protein kinase CK1 delta (CK1δ) inhibitors through structure-based virtual screening

(2008) Giorgio Cozza et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein Kinase CK2 in Human Diseases

(2008) Barbara Guerra et al.   CURRENT MEDICINAL CHEMISTRY

Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo

(2008) C Brockschmidt et al.   GUT

A Central Role for CK1 in Catalyzing Phosphorylation of the p53 Transactivation Domain at Serine 20 after HHV-6B Viral Infection

(2008) Nicola J. MacLaine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase CK2, an important regulator of the inflammatory response?

(2008) Nishi N. Singh et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein

(2008) Elisa A. Waxman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Hypo-Phosphorylation of Salivary Peptidome as a Clue to the Molecular Pathogenesis of Autism Spectrum Disorders

(2008) Massimo Castagnola et al.   JOURNAL OF PROTEOME RESEARCH

Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis

(2008) Giovanni Di Maira et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo

(2008) Silvio E. Perea et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON