Article
Oncology
Joan Jacob, Liezl E. Francisco, Treena Chatterjee, Zhengdong Liang, Shraddha Subramanian, Qingyun J. Liu, Julie H. Rowe, Kendra S. Carmon
Summary: This study identifies GPR56 as a potential therapeutic target for colorectal cancer and demonstrates the efficacy of a GPR56-targeted ADC in preclinical models. The findings suggest that this ADC approach could be a promising treatment option for a large fraction of colorectal cancer patients.
BRITISH JOURNAL OF CANCER
(2023)
Review
Cell & Tissue Engineering
Hanieh Mojtahedi, Niloufar Yazdanpanah, Nima Rezaei
Summary: CML is driven by the BCR-ABL1 oncoprotein, and TKI therapy has been successful. However, mechanisms leading to resistance and disease progression in CML LSCs call for targeted therapies to eradicate them.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Immunology
Rong Fan, Nathan De Beule, Anke Maes, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Ken Maes, Karine Breckpot, Kim De Veirman
Summary: MDSC play a key role in the immunosuppressive microenvironment of hematological cancers, associated with tumor cell survival and drug resistance. Despite intensive studies on the phenotype, function, and prognostic value of MDSC in hematological cancers, therapeutic targeting of this cell population remains challenging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Morgann Klink, Mohammad Atiqur Rahman, Chunhua Song, Pavan Kumar Dhanyamraju, Melanie Ehudin, Yali Ding, Sadie Steffens, Preeti Bhadauria, Soumya Iyer, Cesar Aliaga, Dhimant Desai, Suming Huang, David Claxton, Arati Sharma, Chandrika Gowda
Summary: The study reveals that inhibition of CK2 kinase can enhance the efficacy of chemotherapy drugs in patients with acute myeloid leukemia, especially when used in combination with CX-4945 inhibitor. Additionally, CK2 inhibition can also restore the function of the IKAROS tumor suppressor, increasing the sensitivity of AML cells to apoptosis.
Article
Immunology
Yunguang Hong, Ruiting Wen, Guocai Wu, Shi Li, Wenxin Liu, Zhanghui Chen, Zhigang Yang
Summary: Gr-MDSCs and effector NK cells have significant roles in the pathogenesis of CML. The function of MDSCs is to suppress immune responses, while NK cells are responsible for killing tumor cells. In newly diagnosed CML patients, the proportion of MDSCs is increased and NK cells are decreased. However, upon TKI treatment, the proportion of MDSCs is reduced and NK cells are increased.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Dermatology
Inger Z. M. Kreuger, Roderick C. Slieker, Tim van Groningen, Remco van Doorn
Summary: Loss of CDKN2A is a common occurrence in melanoma progression and targeting this loss can significantly improve treatment outcomes. Various therapeutic strategies, such as CDK4/6 inhibition, cell cycle dysregulation, metabolic rewiring, epigenetic restoration, co-deleted gene targeting, and modulation of immune responses, have been explored in the context of CDKN2A loss.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rongsheng Xu, Huidan Tan, Jiahui Zhang, Zhaoxin Yuan, Qiang Xie, Lan Zhang
Summary: Fam20C, a Golgi casein kinase, is associated with Raine Syndrome and plays a crucial role in biological functions by phosphorylating secreted proteins. Its potential in enhancing cancer metastasis has led to the investigation of small-molecule inhibitors for therapeutic purposes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Oncology
Luca Mologni, Giovanni Marzaro, Sara Redaelli, Alfonso Zambon
Summary: The use of multi-targeting drugs is a new option for cancer treatment, replacing the traditional approach of co-administering multiple drugs. Enhanced and uncontrolled kinase activity in hematological malignancies often drives cancer development, making multi-kinase inhibitors particularly impactful in this context.
Article
Oncology
Javier Bregante, Anna Schoenbichler, Daniel Poeloeske, Lina Degenfeld-Schonburg, Garazi Monzo Contreras, Emir Hadzijusufovic, Elvin D. de Araujo, Peter Valent, Richard Moriggl, Anna Orlova
Summary: FLT3-ITD mutations are common and detrimental in AML, with AML cells quickly developing resistance to FLT3 kinase inhibitors. Through a drug screen, new potential therapeutics like ispinesib, WS6, ponatinib, and cabozantinib have been identified for FLT3-ITD+ AML. Combination therapy with cabozantinib and ispinesib shows strong efficacy against FLT3-ITD+ AML, suggesting promising novel treatment options for this clinical challenge.
Review
Genetics & Heredity
Sajjad Vakili-Samiani, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Vahid Karpisheh, Pooya Jalali, Sara Adibfar, Majid Ahmadi, Abbas Ali Hosseinpour Feizi, Farhad Jadidi-Niaragh
Summary: Hematologic malignancies originate from hematopoietic stem cells and are currently treated with conventional chemotherapy drugs. However, patients with relapsed or refractory diseases have a poor prognosis, necessitating novel therapeutic approaches. Targeting the Wee1 kinase in these malignancies has shown promise as an effective strategy, particularly in enhancing DNA damage repair processes.
Article
Medicine, General & Internal
Sushma Bartaula-Brevik, Calum Leitch, Maria Hernandez-Valladares, Elise Aasebo, Frode S. Berven, Frode Selheim, Annette K. Brenner, Kristin Paulsen Rye, Marie Hagen, Hakon Reikvam, Emmet Mccormack, Oystein Bruserud, Tor Henrik Anderson Tvedt
Summary: V-ATPase inhibitors have dose-dependent antiproliferative and proapoptotic effects on primary AML cells, but the effects vary among patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Juliana Carvalho Santos, Nuria Profitos-Peleja, Salvador Sanchez-Vinces, Gael Roue
Summary: Primarily recognized as a regulator of cytoskeletal dynamics, RHOA is involved in regulating various cellular functions. Deregulated RHOA activity has been linked to cancer growth and metastasis. Recent genomic studies have identified RHOA mutations in leukemia/lymphoma, suggesting its dual role as a tumor promoter or suppressor. Targeting RHOA signaling may offer potential therapeutic strategies for cancer. This review summarizes the molecular mechanisms of RHOA in immune regulation and hematological neoplasms, and discusses current strategies for modulating its activity in these diseases.
Review
Biochemistry & Molecular Biology
Veronika Obsilova, Karolina Honzejkova, Tomas Obsil
Summary: ASK1, a crucial cellular stress sensor, activates JNKs and p38 MAPKs which when excessively activated can lead to cell death, inflammation and fibrosis. Targeted inhibition of ASK1, the upstream activator of these kinases, is a promising therapeutic strategy for treating various severe conditions including neurological disorders, cardiovascular diseases, diabetes and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Tobias Achu Muluh, Xing-sheng Shu, Ying Ying
Summary: Cancer metabolism is the unique utilization of nutrients and energy by cancer cells to support their growth and proliferation. This metabolic profile is characterized by an increased reliance on glucose and glutamine as energy sources and changes in key metabolic intermediates. The study of cancer metabolism aims to understand these metabolic changes and identify potential therapeutic targets for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Kalpana K. Bhanumathy, Amrutha Balagopal, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Andrew Freywald, Vincenzo Giambra
Summary: Protein phosphorylation is a key regulatory mechanism controlling cellular responses, catalysed by members of the protein kinase superfamily. Tyrosine kinases have been extensively studied for their roles in human malignancies, leading to the development of targeted therapies. Various tyrosine kinases, both receptor and nonreceptor types, play critical roles in the pathogenesis and drug resistance of leukemia, highlighting their potential as therapeutic targets.
Article
Orthopedics
Lin Lin, Hai-jun Wang, Yong-jian Wang, Jian Wang, You-rong Chen, Jia-kuo Yu
Summary: This study aimed to compare the clinical outcomes and return to sport (RTS) between patients undergoing revision ACL reconstruction (R-ACLR) and primary ACL reconstruction (P-ACLR). The study found that R-ACLR patients had similar clinical scores but significantly lower RTS compared to P-ACLR patients, and fear of reinjury was the most common factor causing sport changes in R-ACLR patients.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Obstetrics & Gynecology
Heling Bao, Yun Zhao, Xiaosong Zhang, Hui Bi, Shu Cong, Liwen Fang, Hai-Jun Wang, Linhong Wang
Summary: This study evaluated HPV-negative cervical high-grade precancerous lesions or cancer in China. It found that the prevalence of HPV-negative CIN2+ was low and the lesions were smaller compared to HPV-positive cases. Colposcopy should be considered for symptomatic or previously HPV-positive women with HPV-negative results.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Letter
Orthopedics
Zijie Xu, Pei Zhao, Yi-Fan Song, Hai-Jun Wang, Aiguo Zhou, Jia-Kuo Yu
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Zhichao Yuan, Hai -Jun Wang, Qin Li, Tao Su, Jie Yang, Junjun Chen, Yuanzhou Peng, Shuang Zhou, Heling Bao, Shusheng Luo, Hui Wang, Jue Liu, Na Han, Yuming Guo, Yuelong Ji
Summary: This study aimed to investigate the lag effects of weekly exposure to fine particulate matter (PM) from preconception to delivery on the risk of hypertensive disorders of pregnancy (HDPs). Through analyzing data from the Peking University Retrospective Birth Cohort, it was found that PM1 and PM2.5 were significantly associated with an increased hazard of HDPs, with significant lag windows. Stratified analysis revealed that pregnant women who were employed, had low education, and were primiparous were more vulnerable to PM exposure.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Environmental Sciences
Zhichao Yuan, Qin Li, Tao Su, Jie Yang, Junjun Chen, Yuanzhou Peng, Shuang Zhou, Heling Bao, Shusheng Luo, Hui Wang, Jue Liu, Na Han, Yuming Guo, Yuelong Ji, Hai-Jun Wang
Summary: This study aimed to assess the trimester-specific effects of PM2.5 and PM1 prior to the diagnosis of de novo HDP. The results showed that exposure to PM2.5 and PM1 during the first and early second trimesters was positively associated with the risk of de novo HDP. Pregnant women with maternal age above 35 and low maternal education level had a stronger association between fine particulate matter exposure and the risk of HDP. These findings highlight the importance of fine particulate matter in the development of hypertensive disorders of pregnancy.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew
Summary: A certain diet can enhance the activity of the aryl hydrocarbon receptor (AHR) in the intestinal tract, which is responsible for maintaining intestinal barrier homeostasis. This is possibly achieved through the role of certain dietary substrates as CYP1A1/1B1 substrates, which increase the half-life of potent AHR ligands. The gut bacterial metabolite urolithin A (UroA) has been identified as one of these substrates, and its intake can lead to increased AHR activity in key barrier tissues.
Article
Public, Environmental & Occupational Health
Shuang Zhou, Yuming Guo, Tao Su, Gongbo Chen, Hui Liu, Qin Li, Heling Bao, Yuelong Ji, Shusheng Luo, Zheng Liu, Hui Wang, Jue Liu, Na Han, Hai-Jun Wang
Summary: This study examined the individual and joint effects of indoor air pollution and ambient particulate matter on fetal growth in Beijing, China. The findings showed that both factors had negative effects on fetal growth.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemical Research Methods
Huifang Zhu, Yongzhen Li, Jingyu Guo, Shuang Feng, Hong Ge, Chuansha Gu, Mengyao Wang, Ruicong Nie, Na Li, Yongxia Wang, Haijun Wang, Jiateng Zhong, Xinlai Qian, Guoyang He
Summary: This study used iTRAQ labeling proteomics and TMT labeling phosphoproteomics to identify differential proteins and phosphoproteins in colorectal cancer (CRC). The findings suggest that these proteins play important regulatory roles in tumorigenesis and are associated with biological and metabolic processes through binding to other molecules. Specifically, the up-regulation of the stem-loop binding protein (SLBP) in CRC cells promotes cell proliferation and migration. The integrated proteomic and phosphoproteomic analysis provides insights for diagnosing and treating CRC.
JOURNAL OF PROTEOMICS
(2023)
Article
Materials Science, Multidisciplinary
Bin-Bin Yu, Yinghui Wu, Haijun Wang, Xuanang Hu, Zhifeng Zhang, ShuBo Wang, George Y. Chen, Qi Qin, Long-Biao Huang
Summary: Through the study of perovskite solar cells, it is found that post-treating FASnI3 films with phenethylammonium chloride (PEACl) can improve film morphology and passivate defects, thereby enhancing the photovoltaic performance.
MATERIALS & DESIGN
(2023)
Article
Obstetrics & Gynecology
Yuelong Ji, Jinhui Xu, Tao Su, Lizi Lin, Shuang Zhou, Heling Bao, Zheng Liu, Shusheng Luo, Xiangrong Xu, Na Han, Hai-Jun Wang
Summary: This study investigated the effect of LT4 treatment on fetal growth and birth weight among pregnant women with mild subclinical hypothyroidism and TPOAb(-). The results showed that LT4 treatment was associated with decreased fetal head circumference in this population.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Oncology
Jinglong Zhang, Fan Zhang, Kenneth I. Porter, Panshak P. Dakup, Shuwen Wang, Gavin P. Robertson, Shobhan Gaddameedhi, Jiyue Zhu
Summary: Telomerase activation is crucial for melanomagenesis, but is hindered by telomere dysfunction in mice. The study found that telomere dysfunction delays melanoma development and leads to DNA damage and genomic instability.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Mei Luo, Rui Tang, Haijun Wang
Summary: This study aims to evaluate the immune landscape in different lineages of pituitary neuroendocrine tumors (PitNETs) and determine the potential role of pituitary transcription factors in reshaping the tumor immune microenvironment (TIME), thus promoting the application of current immunotherapy for aggressive and metastatic PitNETs.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Environmental Sciences
Xinyu Zhang, Ying Li, Kexin Zhang, Yansong Yin, Jie Wang, Luocheng Wang, Zhexing Wang, Ruiling Zhang, Haijun Wang, Zhong Zhang
Summary: Graphene oxide (GO) is widely used in various fields and its release into the environment is increasing. It has been found that GO leads to bacterial overgrowth and affects bacteriophage infection. The presence of GO expands biofilms and hinders the ability of bacteriophages to kill bacteria and reproduce. Additionally, adding GO to sewage increases bacterial diversity and richness.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Hematology
Jiale Ma, Yan Gu, Yanhui Wei, Xuee Wang, Peixuan Wang, Chunhua Song, Zheng Ge
Summary: The study validated the prognostic power of IPSS-M in MDS patients based on real-world data, showing higher sensitivity and accuracy compared to other prognostic scoring systems. However, further research is needed to explore appropriate treatment options for different IPSS-M risk stratified groups.
Article
Clinical Neurology
Sijie Chen, Longsheng Huang, Guihua Liu, Jie Kang, Qinfang Qian, Jingrong Wang, Rong Wang, Lizhen Zheng, Haijun Wang, Ping Ou
Summary: Acupuncture can improve symptoms of autism spectrum disorder (ASD), and the improvement of the serotonin system may be one of the main regulatory mechanisms of acupuncture for treating ASD.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)