Ikaros fingers on lymphocyte differentiation

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

(2014) Ila Joshi et al.   NATURE IMMUNOLOGY

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

Transcriptional regulation of the Ikzf1 locus

(2013) T. Yoshida et al.   BLOOD

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

(2013) Anita K. Gandhi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Multiple myeloma-initiating cells

(2013) Naoki Hosen   INTERNATIONAL JOURNAL OF HEMATOLOGY

Current approaches for the treatment of multiple myeloma

(2013) Reiko Watanabe et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Complementary regulation of early B-lymphoid differentiation by genetic and epigenetic mechanisms

(2013) Takafumi Yokota et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

(2013) Hilde Schjerven et al.   NATURE IMMUNOLOGY

The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment

(2013) Elisa Laurenti et al.   NATURE IMMUNOLOGY

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

Current evidence for an inherited genetic basis of childhood acute lymphoblastic leukemia

(2012) Kevin Y. Urayama et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations

(2012) A Dupuis et al.   LEUKEMIA

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Pathogenesis of Myeloma

(2011) Kenneth C. Anderson et al.   Annual Review of Pathology-Mechanisms of Disease

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

(2011) Jiangwen Zhang et al.   NATURE IMMUNOLOGY

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

(2010) R. Jeannet et al.   BLOOD

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

(2010) T. D. Ashworth et al.   BLOOD

Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis

(2010) Pablo Gómez-del Arco et al.   IMMUNITY

A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model

(2010) Hiroshi Kawamoto et al.   IMMUNOLOGICAL REVIEWS

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development

(2010) Sergei Doulatov et al.   NATURE IMMUNOLOGY

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY

Genetic inactivation of Ikaros is a rare event in human T-ALL

(2009) Ambroise Marçais et al.   LEUKEMIA RESEARCH

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells

(2008) R. Mansson et al.   BLOOD

The role of the chromatin remodeler Mi-2  in hematopoietic stem cell self-renewal and multilineage differentiation

(2008) T. Yoshida et al.   GENES & DEVELOPMENT

E2A Proteins Promote Development of Lymphoid-Primed Multipotent Progenitors

(2008) Sheila Dias et al.   IMMUNITY

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE

Adult T-cell progenitors retain myeloid potential

(2008) Haruka Wada et al.   NATURE

The earliest thymic progenitors for T cells possess myeloid lineage potential

(2008) J. Jeremiah Bell et al.   NATURE