Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

Lipopolysaccharide blocks induction of unfolded protein response in human hepatoma cell lines

(2013) Xia Jiang et al.   IMMUNOLOGY LETTERS

Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

(2013) Eric C. Hales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

(2013) F Guo et al.   LEUKEMIA

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

(2013) L R Martins et al.   LEUKEMIA

Molecular monitoring in NUP214-ABL-positive T-acute lymphoblastic leukemia reveals clonal diversity and helps to guide targeted therapy

(2013) S Koschmieder et al.   LEUKEMIA

CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway

(2013) R C Prins et al.   LEUKEMIA

Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia

(2013) N C Correia et al.   LEUKEMIA

Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: Biochemical evidence and therapeutic perspectives

(2013) Christian Borgo et al.   Molecular Oncology

Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts

(2013) Gilles M. Leclerc et al.   PLoS One

CK2 regulates ATF4 and CHOP transcription within the cellular stress response signalling pathway

(2012) Carolin C. Schneider et al.   CELLULAR SIGNALLING

Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress-Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response

(2012) S. Manni et al.   CLINICAL CANCER RESEARCH

Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development

(2012) Shiro Soga et al.   CURRENT PHARMACEUTICAL DESIGN

Suppression of survival signalling pathways by the phosphatase PHLPP

(2012) Audrey K. O’Neill et al.   FEBS Journal

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

(2012) J S Blackburn et al.   LEUKEMIA

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia

(2012) C Simioni et al.   LEUKEMIA

FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation

(2012) A Malyukova et al.   LEUKEMIA

Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL

(2012) L Lhermitte et al.   LEUKEMIA

Glucocorticoid sensitivity of T-cell lymphoblastic leukemia/lymphoma is associated with glucocorticoid receptor-mediated inhibition of Notch1 expression

(2012) S Cialfi et al.   LEUKEMIA

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial

(2012) S Jenkinson et al.   LEUKEMIA

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

(2012) F Piazza et al.   LEUKEMIA

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

(2012) C Shepherd et al.   LEUKEMIA

Hyperactivation of 4E-Binding Protein 1 as a Mediator of Biguanide-Induced Cytotoxicity during Glucose Deprivation

(2012) J. Matsuo et al.   MOLECULAR CANCER THERAPEUTICS

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Inhibition of Casein Kinase 2 Modulates XBP1-GRP78 Arm of Unfolded Protein Responses in Cultured Glial Cells

(2012) Toru Hosoi et al.   PLoS One

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias

(2011) A. Silva et al.   CANCER RESEARCH

Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia

(2011) C Evangelisti et al.   LEUKEMIA

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications

(2011) C Grimaldi et al.   LEUKEMIA

An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways

(2011) M Lv et al.   LEUKEMIA

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

(2011) Silvio E. Perea et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia

(2011) J. N. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

(2010) R. Prudent et al.   CANCER RESEARCH

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia

(2010) Camilla Evangelisti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

(2010) Fabrice Pierre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

(2009) Maria Ruzzene et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of cell proliferation and survival: Convergence of protein kinases and caspases

(2009) James S. Duncan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

(2009) Giovanni Di Maira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Kinase CK2 in Health and Disease

(2009) L. A. Pinna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Kinase CK2 in Health and Disease

(2009) N. A. St-Denis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Contribution of bone microenvironment to leukemogenesis and leukemia progression

(2009) F Ayala et al.   LEUKEMIA

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET