Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia

Relapsed Acute Myeloid Leukemia: Need for Innovative Treatment Strategies to Improve Outcome

(2015) Talha Badar et al.   Clinical Lymphoma Myeloma & Leukemia

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells

(2015) Andreas Reinisch et al.   SEMINARS IN HEMATOLOGY

Molecular Integration of HoxB4 and STAT3 for Self-Renewal of Hematopoietic Stem Cells: A Model of Molecular Convergence for Stemness

(2014) Sung-Hyun Hong et al.   STEM CELLS

Deletion of the NF- B subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

(2013) S. J. Stein et al.   BLOOD

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

(2013) Laura Quotti Tubi et al.   Journal of Hematology & Oncology

Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy

(2012) J. S. Logue et al.   GENES & DEVELOPMENT

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

(2012) F Piazza et al.   LEUKEMIA

Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1

(2012) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway

(2011) Y. Zheng et al.   BLOOD

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

(2011) Fabrice Pierre et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis

(2010) Alberto M. Martelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

Highly Phosphorylated FOXO3A Is an Adverse Prognostic Factor in Acute Myeloid Leukemia

(2010) S. M. Kornblau et al.   CLINICAL CANCER RESEARCH

Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus

(2010) Hongge Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential cytogenomics and miRNA signature of the Acute Myeloid Leukaemia Kasumi-1 cell line CD34+38− compartment

(2010) Laura Pedranzini et al.   LEUKEMIA RESEARCH

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Hyaluronan substratum induces multidrug resistance in human mesenchymal stem cells via CD44 signaling

(2009) Chi-Mou Liu et al.   CELL AND TISSUE RESEARCH

The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors

(2009) Ahmed Essaghir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The regulatory β-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis

(2008) C W Yde et al.   ONCOGENE