Epigenetic regulation in cell senescence

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

(2017) Cedric R. Clapier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance

(2017) Reiner A. Veitia et al.   TRENDS IN CELL BIOLOGY

Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses

(2017) Mizuho Sakaki et al.   PLoS One

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan

(2016) Marco Giorgio et al.   AGING CELL

Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

(2016) Alexandra Bernadotte et al.   Aging-US

The Substrate Specificity of Sirtuins

(2016) Poonam Bheda et al.   Annual Review of Biochemistry

MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background

(2016) Zhimin Ye et al.   CANCER LETTERS

Splicing of Nascent RNA Coincides with Intron Exit from RNA Polymerase II

(2016) Fernando Carrillo Oesterreich et al.   CELL

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

(2016) Sungyul Lee et al.   CELL

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status

(2016) Tarique Anwar et al.   CELL CYCLE

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

(2016) Joshua B. Black et al.   Cell Stem Cell

Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic AneurysmNovelty and Significance

(2016) Hou-Zao Chen et al.   CIRCULATION RESEARCH

SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

(2016) Luca Tordella et al.   GENES & DEVELOPMENT

MLL1 is essential for the senescence-associated secretory phenotype

(2016) Brian C. Capell et al.   GENES & DEVELOPMENT

UTX demethylase activity is required for satellite cell–mediated muscle regeneration

(2016) Hervé Faralli et al.   JOURNAL OF CLINICAL INVESTIGATION

Methylation profiling by bisulfite sequencing analysis of the mtDNA Non-Coding Region in replicative and senescent Endothelial Cells

(2016) Valentina Bianchessi et al.   MITOCHONDRION

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

(2016) Kelly M. Anderson et al.   NATURE

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Histone availability as a strategy to control gene expression

(2016) Félix Prado et al.   RNA Biology

The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomes

(2016) Zhuo Wang et al.   RNA Biology

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

(2016) S. John Liu et al.   SCIENCE

The Role of SWI/SNF Chromatin Remodeling Complexes in Hormone Crosstalk

(2016) Elzbieta Sarnowska et al.   TRENDS IN PLANT SCIENCE

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21

(2016) Hyemin Lee et al.   Oncotarget

The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer

(2016) Jun‑jun Qiu et al.   Oncotarget

Epigenetic clock analyses of cellular senescence and ageing

(2016) Donna Lowe et al.   Oncotarget

Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice

(2015) Raúl Soriano-Cantón et al.   AGING CELL

The Roles of Cellular and Organismal Aging in the Development of Late-Onset Maladies

(2015) Filipa Carvalhal Marques et al.   Annual Review of Pathology-Mechanisms of Disease

SWI/SNF Chromatin Remodeling and Human Malignancies

(2015) Julien Masliah-Planchon et al.   Annual Review of Pathology-Mechanisms of Disease

Anti-senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cells

(2015) Youn Seo Oh et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a

(2015) W. Hu et al.   BLOOD

De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins

(2015) Tiziana Squillaro et al.   CELL CYCLE

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

HDAC4 stabilizes SIRT1 via sumoylation SIRT1 to delay cellular senescence

(2015) Xiaolin Han et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis

(2015) Peter M. Brownlee et al.   DNA REPAIR

Histone deacetylase inhibitor valproic acid promotes the induction of pluripotency in mouse fibroblasts by suppressing reprogramming-induced senescence stress

(2015) Yingying Zhai et al.   EXPERIMENTAL CELL RESEARCH

Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus

(2015) Bai Jie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation

(2015) Cheng-Lin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition

(2015) Hua Qing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation

(2015) Qiong Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF

(2015) Nilanjana Chatterjee et al.   MOLECULAR AND CELLULAR BIOLOGY

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability

(2015) Lingling Cao et al.   PLoS One

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma

(2015) Zhaojian Gong et al.   TUMOR BIOLOGY

A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus

(2015) Sandra Lazorthes et al.   Nature Communications

The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence

(2015) Marta Montes et al.   Nature Communications

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

(2015) Jie Zhang et al.   Oncotarget

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

(2015) Sonja Hänzelmann et al.   Clinical Epigenetics

The Four Layers of Aging

(2015) Ran Zhang et al.   Cell Systems

Knockdown of CDK2AP1 in Primary Human Fibroblasts Induces p53 Dependent Senescence

(2015) Khaled N. Alsayegh et al.   PLoS One

SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

(2015) Tomohisa Hayakawa et al.   PLoS One

Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes

(2015) Yasuo Ido et al.   PLoS One

BRG1, the ATPase subunit of SWI/SNF chromatin remodeling complex, interacts with HDAC2 to modulate telomerase expression in human cancer cells

(2014) Shu Wu et al.   CELL CYCLE

Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing

(2014) Hong Qian et al.   EXPERIMENTAL DERMATOLOGY

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

(2014) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination

(2014) Dimitri Conomos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

(2014) M A Macha et al.   ONCOGENE

Ageing as developmental decay: insights from p16INK4a

(2014) Nadine Martin et al.   TRENDS IN MOLECULAR MEDICINE

Histone H3.3 and its proteolytically processed form drive a cellular senescence programme

(2014) Luis F. Duarte et al.   Nature Communications

5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia

(2014) Cindy Grandjenette et al.   NEOPLASIA

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway

(2013) Bin Zhang et al.   AGE

A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

(2013) Anna Bielak-Zmijewska et al.   BIOGERONTOLOGY

ARID1B, a member of the human SWI/SNF chromatin remodeling complex, exhibits tumour-suppressor activities in pancreatic cancer cell lines

(2013) M Khursheed et al.   BRITISH JOURNAL OF CANCER

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization

(2013) Armelle Corpet et al.   CELL CYCLE

The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability

(2013) Jin-Na Min et al.   CELL RESEARCH

Radiation-induced epigenetic DNA methylation modification of radiation-response pathways

(2013) Deborah A Antwih et al.   Epigenetics

Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence

(2013) J. M. Platt et al.   GENES & DEVELOPMENT

BRG1 Is Required for Formation of Senescence-Associated Heterochromatin Foci Induced by Oncogenic RAS or BRCA1 Loss

(2013) Zhigang Tu et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells

(2013) S. Venturelli et al.   MOLECULAR CANCER THERAPEUTICS

Locus-specific editing of histone modifications at endogenous enhancers

(2013) Eric M Mendenhall et al.   NATURE BIOTECHNOLOGY

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

The future of epigenetic therapy in solid tumours—lessons from the past

(2013) Nilofer Azad et al.   Nature Reviews Clinical Oncology

Histone modifications control DNA methylation profiles during ageing and tumour expansion

(2013) Jens Przybilla et al.   Frontiers in Life Science

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress

(2013) Yan Y. Sanders et al.   Redox Biology

SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence

(2012) Anna Cardus et al.   CARDIOVASCULAR RESEARCH

Pluripotent stem cells escape from senescence-associated DNA methylation changes

(2012) C. M. Koch et al.   GENOME RESEARCH

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

(2012) Tamir Chandra et al.   MOLECULAR CELL

Oct4 and Nanog Directly Regulate Dnmt1 to Maintain Self-Renewal and Undifferentiated State in Mesenchymal Stem Cells

(2012) Chih-Chien Tsai et al.   MOLECULAR CELL

Centenarians: Great expectations

(2012) Michael Eisenstein   NATURE

Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes

(2012) Cedric R. Clapier et al.   NATURE

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

Monitoring of cellular senescence by DNA-methylation at specific CpG sites

(2011) Carmen M. Koch et al.   AGING CELL

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation

(2011) S.-H. Park et al.   JOURNAL OF GENERAL VIROLOGY

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells

(2011) Akiko Takahashi et al.   MOLECULAR CELL

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1

(2010) V Borgdorff et al.   ONCOGENE

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

(2010) A. E. Burrows et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs

(2009) Stefan Schoeftner et al.   EMBO JOURNAL

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE