Review
Cell Biology
Heng Wee Tan, Yan-Ming Xu, San-Hai Qin, Guo-Feng Chen, Andy T. Y. Lau
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, with angiogenesis playing a crucial role in the growth and metastasis of lung cancer cells. While genetic regulation of angiogenesis in lung cancer is extensively studied, relatively less is known about the epigenetic regulation. Epigenetic alterations, including DNA epimodifications, histone posttranslational modifications, and noncoding RNA expression, contribute to regulating angiogenesis in lung cancer. In the future, epigenetic-based therapy is likely to emerge as a prominent approach for treating lung cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Matin Miryeganeh
Summary: Senescence is a major developmental transition in plants that involves gene reprogramming and multilevel regulation. Transcription factors and epigenetic mechanisms play crucial roles in senescence-related genes, in addition to genetic reprogramming.
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yuexuan Wang, Yu Han, Yuzhen Jin, Qiang He, Zhicheng Wang
Summary: This study discusses the pathogenesis of cancer and the impact of radiotherapy on cancer. It has been found that epigenetic modification plays an important role in the occurrence and development of cancer. Radiation therapy affects the epigenetic modifications of DNA, chromatin, etc., which in turn affects the treatment outcomes. Therefore, studying the interaction between radiotherapy and epigenetic modifications can help us better understand cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nor Hayati Ismail, Ali Mussa, Nur Atikah Zakaria, Mutaz Jamal Al-Khreisat, Muhamad Aidil Zahidin, Noor Nabila Ramli, Siti Nur Nabeela A'ifah Mohammad, Rosline Hassan, Noor Haslina Mohd Noor, Salfarina Iberahim, Zefarina Zulkafli, Shafini Mohamed Yusoff, Azlan Husin, Muhammad Farid Johan
Summary: Multiple myeloma (MM) is a complex and heterogeneous disease caused by the abnormal proliferation of malignant monoclonal plasma cells in the bone marrow. Despite recent improvements in treatment outcomes, MM is still considered incurable and requires new medications or therapeutic strategies to overcome resistance. Genetic abnormalities and epigenetic changes play important roles in the pathogenesis and development of the disease, making epigenetic pathways potential targets for novel treatments.
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Article
Biochemistry & Molecular Biology
Alison C. Brewer
Summary: The epigenetic landscape plays a crucial role in gene transcription and cellular phenotype determination, with chromatin remodelling during cellular differentiation being a key factor. Redox-dependent molecular mechanisms, including NADPH oxidases generating ROS, are important in regulating epigenetic changes. The role of NADPH oxidases in redox-dependent chromatin remodelling and the impact of epigenetic changes on ROS-producing enzymes are discussed in relation to cellular differentiation and homeostasis, particularly focusing on Nox4.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Multidisciplinary Sciences
Ayoob Obaid Alfalahi, Zeyad Tariq Hussein, Ahlam Khalofah, Monther Taha Sadder, Jamal Ragheb Qasem, Jameel Mohammed Al-Khayri, Shri Mohan Jain, Ali Fadaam Almehemdi
Summary: Epigenetic variations are non-genetic effects that can be inherited and occur beyond DNA sequence. They play a key role in gene expression regulation, hybrid vigor, inbreeding depression, and response to stress. DNA methylation and biochemical modifications are important in development, differentiation, and gene expression regulation. Epigenetics provides explanations for plant breeding aspects.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Haoyu Yin, Yujia Xie, Pei Gu, Wei Li, Yingdie Zhang, Yuxin Yao, Weihong Chen, Jixuan Ma
Summary: Silicosis is a severe occupational disease characterized by pulmonary fibrosis, for which specific treatments are currently lacking. Epigenetic regulation, including DNA methylation, ncRNA, and histone modifications, plays a significant role in the pathogenesis of silicosis. The identification of aberrant epigenetic markers provides new biomarkers for prediction and diagnosis of silicosis.
CLINICAL EPIGENETICS
(2022)
Review
Endocrinology & Metabolism
Yuexin Xu, Jing Ma, Guohua Xu, Duan Ma
Summary: Osteoporosis, a common metabolic bone disease, is primarily diagnosed based on bone mineral density and studies have shown that epigenetics play a significant role in its pathogenesis, involving mechanisms such as DNA methylation and histone modifications. Recent research has also revealed that susceptibility loci and misregulation of epigenetic modifiers are key factors in the development of osteoporosis.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Review
Environmental Sciences
Rui Yan, Xu-Li Chen, Yan-Ming Xu, Andy T. Y. Lau
Summary: Research has shown that e-cigarette aerosols contain many toxic compounds that can adversely affect the human epigenome. Ingredients in e-cigarettes such as nicotine, volatile organic compounds, etc., can also affect DNA methylation, leading to the development of diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Laboni Roy, Oishika Chatterjee, Debopriya Bose, Ananya Roy, Subhrangsu Chatterjee
Summary: The epigenetic landscape plays a crucial role in cellular homeostasis and its disruption can lead to cancer. Noncoding RNA networks, through regulation of processes like histone modification and DNA methylation, are key intracellular components involved in controlling cellular epigenetic characteristics. Understanding the effects of these RNA networks on epigenetic programming is important for the development of targeted cancer therapeutics.
DRUG DISCOVERY TODAY
(2023)
Article
Cell & Tissue Engineering
Peng Xu, Ting-ting Wang, Xiu-zhen Liu, Nan-Yu Wang, Li-hong Sun, Zhu-qin Zhang, Hou-zao Chen, Xiang Lv, Yue Huang, De-Pei Liu
STEM CELL RESEARCH & THERAPY
(2019)
Review
Endocrinology & Metabolism
Shuang Zhou, Xiaoqiang Tang, Hou-Zao Chen
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Cell Biology
Jian-Fei Pei, Xun-Kai Li, Wen-Qi Li, Qian Gao, Yang Zhang, Xiao-Man Wang, Jia-Qi Fu, Shen-Shen Cui, Jia-Hua Qu, Xiang Zhao, De-Long Hao, Dapeng Ju, Na Liu, Kate S. Carroll, Jing Yang, Eric Erquan Zhang, Ji-Min Cao, Hou-Zao Chen, De-Pei Liu
NATURE CELL BIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Xuexian Fang, Zhaoxian Cai, Hao Wang, Dan Han, Qi Cheng, Pan Zhang, Feng Gao, Yingying Yu, Zijun Song, Qian Wu, Peng An, Sicong Huang, Jianwei Pan, Hou-Zao Chen, Jinghai Chen, Andreas Linkermann, Junxia Min, Fudi Wang
CIRCULATION RESEARCH
(2020)
Review
Endocrinology & Metabolism
Shuang Zhou, Yi-Min Dai, Xiao-Feng Zeng, Hou-Zao Chen
FRONTIERS IN ENDOCRINOLOGY
(2020)
Review
Endocrinology & Metabolism
Xiaoqiang Tang, Pei-Heng Li, Hou-Zao Chen
FRONTIERS IN ENDOCRINOLOGY
(2020)
Review
Cell Biology
Pei-Heng Li, Ran Zhang, Li-Qin Cheng, Jin-Jing Liu, Hou-Zao Chen
AGEING RESEARCH REVIEWS
(2020)
Review
Cell Biology
Evandro F. Fang, Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, Johannes Frank, Jing Liao, Huachun Zou, Ninie Y. Wang, Jing Wu, Xiaoting Liu, Tao Li, Yuan Fang, Zhangming Niu, Guang Yang, Jiangshui Hong, Qian Wang, Guobing Chen, Jun Li, Hou-Zao Chen, Lin Kang, Huanxing Su, Brian C. Gilmour, Xinqiang Zhu, Hong Jiang, Na He, Jun Tao, Sean Xiao Leng, Tanjun Tong, Jean Woo
AGEING RESEARCH REVIEWS
(2020)
Letter
Cardiac & Cardiovascular Systems
Chuanli Ren, Peiheng Li, Hou-Zao Chen
Article
Biochemical Research Methods
Jiang-Feng Liu, Song-Feng Wu, Shu Liu, Xin Sun, Xiao-Man Wang, Ping Xu, Hou-Zao Chen, Jun-Tao Yang
Review
Pharmacology & Pharmacy
Fang Wang, Hou-Zao Chen
FRONTIERS IN PHARMACOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Xiaoqiang Tang, Xiao-Feng Chen, Xin Sun, Peng Xu, Xiang Zhao, Ying Tong, Xiao-Man Wang, Ke Yang, Yu-Tong Zhu, De-Long Hao, Zhu-Qin Zhang, De-Pei Liu, Hou-Zao Chen
Editorial Material
Peripheral Vascular Disease
Xiao-Man Wang, He-Ping Wang, Hou-Zao Chen, De-Pei Liu
Letter
Medicine, General & Internal
Li Weng, Yang Jiao, Yue Li
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Multidisciplinary Sciences
Ran Zhang, Xu Wang, Jia-Hua Qu, Bing Liu, Peng Zhang, Tao Zhang, Peng-Cheng Fan, Xiao-Man Wang, Guang-Yuan Xiao, Ye Su, Yan Xie, Yue Liu, Jian-Fei Pei, Zhu-Qin Zhang, De-Long Hao, Ping Xu, Hou-Zao Chen, De-Pei Liu