Targeting the Fas/FasL signaling pathway in cancer therapy

The Thrombospondin-1 Mimetic ABT-510 Increases the Uptake and Effectiveness of Cisplatin and Paclitaxel in a Mouse Model of Epithelial Ovarian Cancer

(2015) Nicole E. Campbell et al.   NEOPLASIA

Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity

(2014) A. Krippner-Heidenreich et al.   JOURNAL OF IMMUNOLOGY

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis

(2011) Li Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia

(2011) Tomoyuki Tsumuraya et al.   BIOCHEMICAL PHARMACOLOGY

Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer

(2011) Wan-Wan Lin et al.   BIOCHEMICAL PHARMACOLOGY

Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases

(2011) Nadezhda V. Koshkina et al.   CANCER

Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death

(2011) Elisabet Ametller et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Selective elimination of pathogenic synovial fluid T-cells from Rheumatoid Arthritis and Juvenile Idiopathic Arthritis by targeted activation of Fas-apoptotic signaling

(2011) Edwin Bremer et al.   IMMUNOLOGY LETTERS

Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways

(2011) Jorn Markus Schattenberg et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor

(2011) Li Huang et al.   LABORATORY INVESTIGATION

Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin

(2011) Ronan J Kelly et al.   Molecular Cancer

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR

(2011) Trever G. Bivona et al.   NATURE

CD40·FasL and CTLA-4·FasL Fusion Proteins Induce Apoptosis in Malignant Cell Lines by Dual Signaling

(2010) Ariel Orbach et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural alterations of the FAS gene in cutaneous T-cell lymphoma (CTCL)

(2010) Jianqiang Wu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reduction of Fas/CD95 Promoter Methylation, Upregulation of Fas Protein, and Enhancement of Sensitivity to Apoptosis in Cutaneous T-Cell Lymphoma

(2010) Jianqiang Wu et al.   ARCHIVES OF DERMATOLOGY

A Phase 1 Trial of ABT-510 Concurrent With Standard Chemoradiation for Patients With Newly Diagnosed Glioblastoma

(2010) Louis B. Nabors et al.   ARCHIVES OF NEUROLOGY

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species-Dependent Signaling Pathway

(2010) M. A. Park et al.   CANCER RESEARCH

Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas , FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility

(2010) María Villa-Morales et al.   CARCINOGENESIS

Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response

(2010) Zhongchen Liu et al.   Cellular & Molecular Immunology

In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts

(2010) F. Mollinedo et al.   CLINICAL CANCER RESEARCH

Matrix Metalloproteinase Inhibitors

(2010) György Dormán et al.   DRUGS

Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells

(2010) Amélie Rebillard et al.   EUROPEAN JOURNAL OF CANCER

Understanding rituximab function and resistance: implications for tailored therapy

(2010) Alfredo Amoroso   Frontiers in Bioscience-Landmark

Aerosol Therapy for the Treatment of Osteosarcoma Lung Metastases: Targeting the Fas/FasL Pathway and Rationale for the Use of Gemcitabine

(2010) Nancy Gordon et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand

(2010) Danish Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoradiotherapy With or Without AE-941 in Stage III Non–Small Cell Lung Cancer: A Randomized Phase III Trial

(2010) Charles Lu et al.   JNCI-Journal of the National Cancer Institute

FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors

(2010) Ivy A Ho et al.   Molecular Cancer

mir-200c Regulates Induction of Apoptosis through CD95 by Targeting FAP-1

(2010) Robert Schickel et al.   MOLECULAR CELL

APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo

(2010) G. Eisele et al.   NEURO-ONCOLOGY

Novel role of thiadiazolidine derivatives in inducing cell death through Myc-Max, Akt, FKHR, and FasL pathway

(2009) Pongali B. Raghavendra et al.   BIOCHEMICAL PHARMACOLOGY

Highly frequent anti-idiotype antibody in cynomolgus monkeys developed against mouse-derived regions of anti-Fas antibody humanized by complementarity determining region grafting

(2009) M Saito-Yabe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells

(2009) L. Lahiry et al.   CARCINOGENESIS

Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation

(2009) I Verbrugge et al.   CELL DEATH AND DIFFERENTIATION

Molecular Mechanisms of Tamoxifen Therapy for Cholangiocarcinoma: Role of Calmodulin

(2009) P. Pawar et al.   CLINICAL CANCER RESEARCH

Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity

(2009) M. Candolfi et al.   CLINICAL CANCER RESEARCH

Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells

(2009) Pepita Gimenez-Bonafe et al.   CURRENT CANCER DRUG TARGETS

Protective effects of HFE7A, mouse anti-human/mouse Fas monoclonal antibody against acute and lethal hepatic injury induced by Jo2

(2009) Hiroko Yoshida et al.   CYTOTECHNOLOGY

Death receptors: Targets for cancer therapy

(2009) Zafar Mahmood et al.   EXPERIMENTAL CELL RESEARCH

Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus

(2009) Lothar F. Fecker et al.   EXPERIMENTAL DERMATOLOGY

The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer

(2009) Evelien W. Duiker et al.   GYNECOLOGIC ONCOLOGY

Randomized Phase II Trial of Denosumab in Patients With Bone Metastases From Prostate Cancer, Breast Cancer, or Other Neoplasms After Intravenous Bisphosphonates

(2009) Karim Fizazi et al.   JOURNAL OF CLINICAL ONCOLOGY

Downregulation of Fas Gene Expression in Sézary Syndrome Is Associated with Promoter Hypermethylation

(2009) Christine L. Jones et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of MMP7 and Its Cross-Talk with the FAS/FASL System during the Acquisition of Chemoresistance to Oxaliplatin

(2009) Vanessa Almendro et al.   PLoS One

Upregulation of miR-23a∼27a∼24-2 Cluster Induces Caspase-Dependent and -Independent Apoptosis in Human Embryonic Kidney Cells

(2009) Ravindresh Chhabra et al.   PLoS One

Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL

(2008) B Rikhof et al.   BRITISH JOURNAL OF CANCER

Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells

(2008) Amel Baya Bouzar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Retrovirally transduced murine T lymphocytes expressing FasL mediate effective killing of prostate cancer cells

(2008) J C Symes et al.   CANCER GENE THERAPY

Superior Activity of Fusion Protein scFvRit:sFasL over Cotreatment with Rituximab and Fas Agonists

(2008) E. Bremer et al.   CANCER RESEARCH

Construction of Optimized Bispecific Antibodies for Selective Activation of the Death Receptor CD95

(2008) T. Herrmann et al.   CANCER RESEARCH

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

(2008) G. Zhang et al.   CLINICAL CANCER RESEARCH

microRNAs and death receptors

(2008) Sun-Mi Park et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Combination of Fasl and GM-CSF confers synergistic antitumor immunity in anin vivo model of the murine Lewis lung carcinoma

(2008) Ming-Yi Ho et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptional Modulation Using HDACi Depsipeptide Promotes Immune Cell-Mediated Tumor Destruction of Murine B16 Melanoma

(2008) Takashi Murakami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of Tumor Growth Using Salmonella Expressing Fas Ligand

(2008) Markus Loeffler et al.   JNCI-Journal of the National Cancer Institute