Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis

A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma

(2014) R. Chen et al.   CANCER RESEARCH

Genetics of breast cancer bone metastasis: a sequential multistep pattern

(2014) Hassan Fazilaty et al.   CLINICAL & EXPERIMENTAL METASTASIS

Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness

(2014) Yansheng Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

High Expression of Protein Tyrosine Kinase 7 Significantly Associates with Invasiveness and Poor Prognosis in Intrahepatic Cholangiocarcinoma

(2014) Jing Jin et al.   PLoS One

PTK 7 Is a Transforming Gene and Prognostic Marker for Breast Cancer and Nodal Metastasis Involvement

(2014) Silvia Gärtner et al.   PLoS One

Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma

(2013) Won-Sik Shin et al.   CANCER SCIENCE

Membrane and actin dynamics interplay at lamellipodia leading edge

(2013) Sara Bisi et al.   CURRENT OPINION IN CELL BIOLOGY

PTK7 modulates Wnt signaling activity via LRP6

(2013) N. Bin-Nun et al.   DEVELOPMENT

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

(2013) Pedro Monteiro et al.   JOURNAL OF CELL BIOLOGY

Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease

(2012) Veronica Munoz-Soriano et al.   CURRENT GENOMICS

The Cytosolic Domain of Protein-tyrosine Kinase 7 (PTK7), Generated from Sequential Cleavage by a Disintegrin and Metalloprotease 17 (ADAM17) and γ-Secretase, Enhances Cell Proliferation and Migration in Colon Cancer Cells

(2012) Hye-Won Na et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Ectodomain Shedding and Processing of Protein-tyrosine Pseudokinase 7 (PTK7)

(2012) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

(2012) Xinzi Yu et al.   JOURNAL OF CELL BIOLOGY

Undetectable and Decreased Expression of KIAA1949 (Phostensin) Encoded on Chromosome 6p21.33 in Human Breast Cancers Revealed by Transcriptome Analysis

(2012) Yan A. Su et al.   Journal of Cancer

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

PTK7: A cell polarity receptor with multiple facets

(2011) Anne-Catherine Lhoumeau et al.   CELL CYCLE

RACK1 is a novel interaction partner of PTK7 that is required for neural tube closure

(2011) Peter Wehner et al.   DEVELOPMENT

PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling

(2011) Hanna Peradziryi et al.   EMBO JOURNAL

Potential Relation of Aberrant Proteolysis of Human Protein Tyrosine Kinase 7 (PTK7)chuzhoiby Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) to Congenital Defects

(2011) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear

(2010) Anju Paudyal et al.   BMC DEVELOPMENTAL BIOLOGY

Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling

(2010) Francesca Puppo et al.   EMBO REPORTS

The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase

(2010) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Planar polarized actomyosin contractile flows control epithelial junction remodelling

(2010) Matteo Rauzi et al.   NATURE

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinase proteomics: substrates, targets, and therapy

(2009) Charlotte J Morrison et al.   CURRENT OPINION IN CELL BIOLOGY

PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation

(2009) W. W. Yen et al.   DEVELOPMENT

Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy

(2009) Y. Wang   MOLECULAR CANCER THERAPEUTICS

Noncanonical Wnt Signaling in Tumor Progression and Metastasis

(2009) Jason R. Jessen   Zebrafish

The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151

(2008) Andries Zijlstra et al.   CANCER CELL

PTK7 recruits dsh to regulate neural crest migration

(2008) I. Shnitsar et al.   DEVELOPMENT