CDK5 in oncology: recent advances and future prospects

Cdk5 links with DNA damage response and cancer

(2017) Wan Liu et al.   Molecular Cancer

Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies

(2017) David J. Byun et al.   Nature Reviews Endocrinology

Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia

(2016) Yixiang Chen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold

(2016) S Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cdk5 Directly Targets Nuclear p21 CIP1 and Promotes Cancer Cell Growth

(2016) Pao-Hsuan Huang et al.   CANCER RESEARCH

Targeting CDK9: a promising therapeutic opportunity in prostate cancer

(2016) Muhammed H Rahaman et al.   ENDOCRINE-RELATED CANCER

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases

(2016) Ladislava Vymětalová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson′s disease

(2016) HarishC Pant et al.   Neural Regeneration Research

STMC-24. NOVEL INHIBITOR OF CDK5 SIGNALING AXIS SUPPRESSES SELF-RENEWAL PROPERTIES OF GBM STEM CELLS AND INDUCES APOPTOSIS

(2016) Subhas Mukherjee et al.   NEURO-ONCOLOGY

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

(2016) Gabriel N. Hortobagyi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

(2016) R. D. Dorand et al.   SCIENCE

Inflammation helps tumors evade immune detection

(2016) L. K. Ferrarelli   Science Signaling

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis

(2016) Kangmin Zhuang et al.   Cell Death & Disease

Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis

(2016) Henriette Merk et al.   Oncotarget

Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma

(2016) Julia Herzog et al.   Oncotarget

Inflammation helps tumors evade immune detection

(2016) L. K. Ferrarelli   Science Signaling

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis

(2016) Ya-Li Zheng et al.   PLoS One

Cyclin I and p35 determine the subcellular distribution of Cdk5

(2015) Henning Hagmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting CDK6 in cancer: State of the art and new insights

(2015) Solomon Tadesse et al.   CELL CYCLE

Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

(2015) Sara Chiker et al.   CELL CYCLE

Tamoxifen Inhibits CDK5 Kinase Activity by Interacting with p35/p25 and Modulates the Pattern of Tau Phosphorylation

(2015) Caroline Corbel et al.   CHEMISTRY & BIOLOGY

Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 – 2014)

(2015) Veronika Malínková et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination

(2015) Toshiyuki Takasugi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Inhibition of CDK5 Increases NOXA Levels through miR-23a Repression

(2015) Trevor M. Morey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance

(2015) Hilal S. Khalil et al.   JOURNAL OF BIOTECHNOLOGY

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach

(2015) Sandra M. Ehrlich et al.   JOURNAL OF HEPATOLOGY

Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development

(2015) Z. Liang et al.   JOURNAL OF NEUROSCIENCE

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

(2015) Julia Lindqvist et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

(2015) Shan-Shan Sun et al.   Molecular Cancer

Cyclin-dependent kinase 5 regulates the proliferation, motility and invasiveness of lung cancer cells through its effects on cytoskeletal remodeling

(2015) JUN-LI LIU et al.   Molecular Medicine Reports

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis

(2015) Shu Zhang et al.   PLoS One

The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production

(2015) Yi Rang Na et al.   Science Signaling

Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread—Identification of a Promising Novel therapeutic target

(2015) Savita Bisht et al.   Translational Oncology

Targeting Breast Cancer with CDK Inhibitors

(2015) Erica L. Mayer   Current Oncology Reports

Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis

(2015) Karine Pozo et al.   Oncotarget

The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production

(2015) Yi Rang Na et al.   Science Signaling

Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors

(2015) Marion Peyressatre et al.   Cancers

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

(2014) Aude Echalier et al.   ACS Chemical Biology

Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening

(2014) Arindam Chatterjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma

(2014) S. K. Kumar et al.   BLOOD

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5

(2014) Hiroyuki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDK5 is a major regulator of the tumor suppressor DLC1

(2014) Brajendra K. Tripathi et al.   JOURNAL OF CELL BIOLOGY

Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

(2014) J-K Jin et al.   ONCOGENE

Exploring structural requirements of leads for improving activity and selectivity against CDK5/p25 in Alzheimer's disease: an in silico approach

(2014) Pravin Ambure et al.   RSC Advances

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

(2013) Mathew P. Martin et al.   ACS Chemical Biology

Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells

(2013) Fu-Ning Hsu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Role of Cdk5 in Neuroendocrine Thyroid Cancer

(2013) Karine Pozo et al.   CANCER CELL

Cyclin I is involved in the regulation of cell cycle progression

(2013) Taiki Nagano et al.   CELL CYCLE

A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors

(2013) Tomáš Gucký et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo

(2013) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

Targeting Constitutively Activated β 1 Integrins Inhibits Prostate Cancer Metastasis

(2013) Yu-Chen Lee et al.   MOLECULAR CANCER RESEARCH

Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance

(2013) C. Haider et al.   MOLECULAR CANCER THERAPEUTICS

Trisubstituted Pyrazolopyrimidines as Novel Angiogenesis Inhibitors

(2013) Sabine B. Weitensteiner et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5

(2012) Abul Arif   BIOCHEMICAL PHARMACOLOGY

Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors

(2012) Jonas Malmström et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling

(2012) Luc Demange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients

(2012) Zachary Levacque et al.   CELL CYCLE

Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance

(2012) G. Ambrosini et al.   CLINICAL CANCER RESEARCH

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases

(2012) Marek Zatloukal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway

(2012) Abeba Demelash et al.   MOLECULAR BIOLOGY OF THE CELL

Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation

(2012) Q Qi et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

An in silico approach for the discovery of CDK5/p25 interaction inhibitors

(2011) Bing Zhang et al.   Biotechnology Journal

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma

(2011) Christopher Abdullah et al.   CELL CYCLE

The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation

(2011) Celeste Bolin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Twice switched at birth: Cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells

(2011) Johanna Liebl et al.   CELLULAR SIGNALLING

Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras

(2011) J. P. Eggers et al.   CLINICAL CANCER RESEARCH

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Regulation of Androgen Receptor and Prostate Cancer Growth by Cyclin-dependent Kinase 5

(2011) Fu-Ning Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity

(2011) Radek Jorda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Cdk5: Multitasking between physiological and pathological conditions

(2011) Joao P. Lopes et al.   PROGRESS IN NEUROBIOLOGY

A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion

(2011) M. Quintavalle et al.   Science Signaling

Cdk5: a multifaceted kinase in neurodegenerative diseases

(2011) Zelda H. Cheung et al.   TRENDS IN CELL BIOLOGY

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

(2010) Georg Feldmann et al.   CANCER RESEARCH

Cdk5, the multifunctional surveyor

(2010) Vassiliki Lalioti et al.   CELL CYCLE

p35 Is Required for CDK5 Activation in Cellular Senescence

(2010) Daqin Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cdk5 Kinase Regulates the STAT3 Transcription Factor to Prevent DNA Damage upon Topoisomerase I Inhibition

(2010) Sandy Courapied et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis

(2010) Johanna Liebl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis

(2010) Tej K. Pareek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

(2010) Shin-ichi Hisanaga et al.   JOURNAL OF NEUROCHEMISTRY

Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replicationin vivo

(2010) Steve D Haenchen et al.   JOURNAL OF NEUROVIROLOGY

Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

(2010) David Parry et al.   MOLECULAR CANCER THERAPEUTICS

The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose

(2010) Xazmin H. Lowman et al.   MOLECULAR CELL

Conditional Deletion of Neuronal Cyclin-Dependent Kinase 5 in Developing Forebrain Results in Microglial Activation and Neurodegeneration

(2009) Satoru Takahashi et al.   AMERICAN JOURNAL OF PATHOLOGY

Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells

(2009) Paul T. Brinkkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

(2009) V. Lalioti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Unusual Member of the Cdk Family: Cdk5

(2008) Fatema A. Dhariwala et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL

Cyclin-Dependent Kinase 5 Supports Neuronal Survival through Phosphorylation of Bcl-2

(2008) Z. H. Cheung et al.   JOURNAL OF NEUROSCIENCE

Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion

(2008) R. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA