标题
CDK5 in oncology: recent advances and future prospects
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 9, Issue 16, Pages 1939-1962
出版商
Future Science, LTD
发表日期
2017-10-27
DOI
10.4155/fmc-2017-0097
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cdk5 links with DNA damage response and cancer
- (2017) Wan Liu et al. Molecular Cancer
- Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies
- (2017) David J. Byun et al. Nature Reviews Endocrinology
- Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia
- (2016) Yixiang Chen et al. BRITISH JOURNAL OF HAEMATOLOGY
- Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold
- (2016) S Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cdk5 Directly Targets Nuclear p21 CIP1 and Promotes Cancer Cell Growth
- (2016) Pao-Hsuan Huang et al. CANCER RESEARCH
- Targeting CDK9: a promising therapeutic opportunity in prostate cancer
- (2016) Muhammed H Rahaman et al. ENDOCRINE-RELATED CANCER
- 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases
- (2016) Ladislava Vymětalová et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson′s disease
- (2016) HarishC Pant et al. Neural Regeneration Research
- STMC-24. NOVEL INHIBITOR OF CDK5 SIGNALING AXIS SUPPRESSES SELF-RENEWAL PROPERTIES OF GBM STEM CELLS AND INDUCES APOPTOSIS
- (2016) Subhas Mukherjee et al. NEURO-ONCOLOGY
- Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer
- (2016) Gabriel N. Hortobagyi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity
- (2016) R. D. Dorand et al. SCIENCE
- Inflammation helps tumors evade immune detection
- (2016) L. K. Ferrarelli Science Signaling
- A unique type of GSK-3 inhibitor brings new opportunities to the clinic
- (2016) A. Licht-Murava et al. Science Signaling
- CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis
- (2016) Kangmin Zhuang et al. Cell Death & Disease
- Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis
- (2016) Henriette Merk et al. Oncotarget
- Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma
- (2016) Julia Herzog et al. Oncotarget
- Inflammation helps tumors evade immune detection
- (2016) L. K. Ferrarelli Science Signaling
- A unique type of GSK-3 inhibitor brings new opportunities to the clinic
- (2016) A. Licht-Murava et al. Science Signaling
- Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis
- (2016) Ya-Li Zheng et al. PLoS One
- Cyclin I and p35 determine the subcellular distribution of Cdk5
- (2015) Henning Hagmann et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Targeting CDK6 in cancer: State of the art and new insights
- (2015) Solomon Tadesse et al. CELL CYCLE
- Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients
- (2015) Sara Chiker et al. CELL CYCLE
- Tamoxifen Inhibits CDK5 Kinase Activity by Interacting with p35/p25 and Modulates the Pattern of Tau Phosphorylation
- (2015) Caroline Corbel et al. CHEMISTRY & BIOLOGY
- Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 – 2014)
- (2015) Veronika Malínková et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination
- (2015) Toshiyuki Takasugi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heat Shock Inhibition of CDK5 Increases NOXA Levels through miR-23a Repression
- (2015) Trevor M. Morey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance
- (2015) Hilal S. Khalil et al. JOURNAL OF BIOTECHNOLOGY
- Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach
- (2015) Sandra M. Ehrlich et al. JOURNAL OF HEPATOLOGY
- Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development
- (2015) Z. Liang et al. JOURNAL OF NEUROSCIENCE
- Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells
- (2015) Julia Lindqvist et al. MOLECULAR BIOLOGY OF THE CELL
- Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma
- (2015) Shan-Shan Sun et al. Molecular Cancer
- Cyclin-dependent kinase 5 regulates the proliferation, motility and invasiveness of lung cancer cells through its effects on cytoskeletal remodeling
- (2015) JUN-LI LIU et al. Molecular Medicine Reports
- The Role of Cdk5 in Alzheimer’s Disease
- (2015) Shu-Lei Liu et al. MOLECULAR NEUROBIOLOGY
- Mitochondrial control by DRP1 in brain tumor initiating cells
- (2015) Qi Xie et al. NATURE NEUROSCIENCE
- The history and future of targeting cyclin-dependent kinases in cancer therapy
- (2015) Uzma Asghar et al. NATURE REVIEWS DRUG DISCOVERY
- CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis
- (2015) Shu Zhang et al. PLoS One
- The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production
- (2015) Yi Rang Na et al. Science Signaling
- Cyclin-Dependent Kinase 5 (CDK5) Controls Melanoma Cell Motility, Invasiveness, and Metastatic Spread—Identification of a Promising Novel therapeutic target
- (2015) Savita Bisht et al. Translational Oncology
- Targeting Breast Cancer with CDK Inhibitors
- (2015) Erica L. Mayer Current Oncology Reports
- Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis
- (2015) Karine Pozo et al. Oncotarget
- The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production
- (2015) Yi Rang Na et al. Science Signaling
- Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors
- (2015) Marion Peyressatre et al. Cancers
- An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States
- (2014) Aude Echalier et al. ACS Chemical Biology
- Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening
- (2014) Arindam Chatterjee et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma
- (2014) S. K. Kumar et al. BLOOD
- Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5
- (2014) Hiroyuki Kobayashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CDK5 is a major regulator of the tumor suppressor DLC1
- (2014) Brajendra K. Tripathi et al. JOURNAL OF CELL BIOLOGY
- Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis
- (2014) J-K Jin et al. ONCOGENE
- Exploring structural requirements of leads for improving activity and selectivity against CDK5/p25 in Alzheimer's disease: an in silico approach
- (2014) Pravin Ambure et al. RSC Advances
- Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains
- (2013) Mathew P. Martin et al. ACS Chemical Biology
- Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells
- (2013) Fu-Ning Hsu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The Role of Cdk5 in Neuroendocrine Thyroid Cancer
- (2013) Karine Pozo et al. CANCER CELL
- Cyclin I is involved in the regulation of cell cycle progression
- (2013) Taiki Nagano et al. CELL CYCLE
- A Novel Series of Highly Potent 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase Inhibitors
- (2013) Tomáš Gucký et al. JOURNAL OF MEDICINAL CHEMISTRY
- Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo
- (2013) J. R. Sundaram et al. JOURNAL OF NEUROSCIENCE
- Targeting Constitutively Activated β 1 Integrins Inhibits Prostate Cancer Metastasis
- (2013) Yu-Chen Lee et al. MOLECULAR CANCER RESEARCH
- Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance
- (2013) C. Haider et al. MOLECULAR CANCER THERAPEUTICS
- Trisubstituted Pyrazolopyrimidines as Novel Angiogenesis Inhibitors
- (2013) Sabine B. Weitensteiner et al. PLoS One
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5
- (2012) Abul Arif BIOCHEMICAL PHARMACOLOGY
- Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors
- (2012) Jonas Malmström et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling
- (2012) Luc Demange et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients
- (2012) Zachary Levacque et al. CELL CYCLE
- Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance
- (2012) G. Ambrosini et al. CLINICAL CANCER RESEARCH
- Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases
- (2012) Marek Zatloukal et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway
- (2012) Abeba Demelash et al. MOLECULAR BIOLOGY OF THE CELL
- Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation
- (2012) Q Qi et al. ONCOGENE
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Cyclin-Dependent Kinases in Brain Development and Disease
- (2011) Susan C. Su et al. Annual Review of Cell and Developmental Biology
- An in silico approach for the discovery of CDK5/p25 interaction inhibitors
- (2011) Bing Zhang et al. Biotechnology Journal
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Expression analysis and molecular targeting of cyclin-dependent kinases in advanced melanoma
- (2011) Christopher Abdullah et al. CELL CYCLE
- The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation
- (2011) Celeste Bolin et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Twice switched at birth: Cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells
- (2011) Johanna Liebl et al. CELLULAR SIGNALLING
- Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras
- (2011) J. P. Eggers et al. CLINICAL CANCER RESEARCH
- Beyond ATM: The protein kinase landscape of the DNA damage response
- (2011) Ariel Bensimon et al. FEBS LETTERS
- Regulation of Androgen Receptor and Prostate Cancer Growth by Cyclin-dependent Kinase 5
- (2011) Fu-Ning Hsu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity
- (2011) Radek Jorda et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
- (2011) Jang Hyun Choi et al. NATURE
- Tumor angiogenesis: molecular pathways and therapeutic targets
- (2011) Sara M Weis et al. NATURE MEDICINE
- Cdk5: Multitasking between physiological and pathological conditions
- (2011) Joao P. Lopes et al. PROGRESS IN NEUROBIOLOGY
- A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion
- (2011) M. Quintavalle et al. Science Signaling
- Cdk5: a multifaceted kinase in neurodegenerative diseases
- (2011) Zelda H. Cheung et al. TRENDS IN CELL BIOLOGY
- Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling
- (2010) Georg Feldmann et al. CANCER RESEARCH
- Cdk5, the multifunctional surveyor
- (2010) Vassiliki Lalioti et al. CELL CYCLE
- p35 Is Required for CDK5 Activation in Cellular Senescence
- (2010) Daqin Mao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The cdk5 Kinase Regulates the STAT3 Transcription Factor to Prevent DNA Damage upon Topoisomerase I Inhibition
- (2010) Sandy Courapied et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis
- (2010) Johanna Liebl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis
- (2010) Tej K. Pareek et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Regulation and role of cyclin-dependent kinase activity in neuronal survival and death
- (2010) Shin-ichi Hisanaga et al. JOURNAL OF NEUROCHEMISTRY
- Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replicationin vivo
- (2010) Steve D Haenchen et al. JOURNAL OF NEUROVIROLOGY
- Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor
- (2010) David Parry et al. MOLECULAR CANCER THERAPEUTICS
- The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose
- (2010) Xazmin H. Lowman et al. MOLECULAR CELL
- Conditional Deletion of Neuronal Cyclin-Dependent Kinase 5 in Developing Forebrain Results in Microglial Activation and Neurodegeneration
- (2009) Satoru Takahashi et al. AMERICAN JOURNAL OF PATHOLOGY
- Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells
- (2009) Paul T. Brinkkoetter et al. JOURNAL OF CLINICAL INVESTIGATION
- Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
- (2009) Bo Tian et al. NATURE CELL BIOLOGY
- The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes
- (2009) V. Lalioti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Unusual Member of the Cdk Family: Cdk5
- (2008) Fatema A. Dhariwala et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
- (2008) Nicholas C Turner et al. EMBO JOURNAL
- Cyclin-Dependent Kinase 5 Supports Neuronal Survival through Phosphorylation of Bcl-2
- (2008) Z. H. Cheung et al. JOURNAL OF NEUROSCIENCE
- Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
- (2008) R. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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