Cdk5 links with DNA damage response and cancer

Role of STAT3 in Genesis and Progression of Human Malignant Gliomas

(2016) Zangbéwendé Guy Ouédraogo et al.   MOLECULAR NEUROBIOLOGY

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

(2015) Michael Goldstein et al.   Annual Review of Medicine

AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis

(2015) Yu Ren et al.   CANCER LETTERS

Deciphering the DNA Damage Response

(2015) James E. Haber   CELL

Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death

(2015) C Kim et al.   CELL DEATH AND DIFFERENTIATION

Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis

(2015) L. Cao et al.   CLINICAL CANCER RESEARCH

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma – A novel therapeutic approach

(2015) Sandra M. Ehrlich et al.   JOURNAL OF HEPATOLOGY

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

(2015) Julia Lindqvist et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

(2015) Shan-Shan Sun et al.   Molecular Cancer

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

RETRACTED ARTICLE: The Crucial Role of Cyclin-Dependent Kinase-5-Ataxia-Telangiectasia Mutated Axis in ICH-Induced Neuronal Injury of Rat Model

(2015) Jing Wu et al.   MOLECULAR NEUROBIOLOGY

Medicine: Eyes on the target

(2015) Michael Eisenstein   NATURE

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

(2015) A. Bakr et al.   NUCLEIC ACIDS RESEARCH

CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis

(2015) Shu Zhang et al.   PLoS One

An immunohistochemical study of cyclin-dependent kinase 5 (CDK5) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker

(2015) Kanglai Wei et al.   World Journal of Surgical Oncology

S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength

(2015) Peng Zhang et al.   Nature Communications

Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer

(2015) Xiu-Xiu Chen et al.   Oncotarget

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons

(2015) Miguel Veas-Pérez de Tudela et al.   Scientific Reports

Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells

(2014) Tatiana Guevara et al.   CELL CYCLE

CDK5 Contributes to Neuronal Apoptosis via Promoting MEF2D Phosphorylation in Rat Model of Intracerebral Hemorrhage

(2014) Kaifu Ke et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity

(2014) Anja Büchner et al.   NEUROMOLECULAR MEDICINE

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

(2014) C. Liu et al.   NUCLEIC ACIDS RESEARCH

Physiological and pathological phosphorylation of tau by Cdk5

(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells

(2013) Fu-Ning Hsu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Emerging Roles of the Nucleolus in Regulating the DNA Damage Response: The Noncanonical DNA Repair Enzyme APE1/Ref-1 as a Paradigmatical Example

(2013) Giulia Antoniali et al.   ANTIOXIDANTS & REDOX SIGNALING

Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo

(2013) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

A first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhibitor, administered weekly in subjects with advanced malignancies

(2013) John J Nemunaitis et al.   Journal of Translational Medicine

Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5

(2012) Abul Arif   BIOCHEMICAL PHARMACOLOGY

Pro-apoptotic signaling pathway by CDK5 and MEKK1

(2012) Hyung Don Ryoo   CELL CYCLE

Phosphorylation of p35 and p39 by Cdk5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner

(2012) A. Asada et al.   JOURNAL OF CELL SCIENCE

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

(2012) Prashant Kumar Modi et al.   MOLECULAR BIOLOGY OF THE CELL

Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5

(2011) Erick Contreras-Vallejos et al.   CELLULAR SIGNALLING

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation

(2011) Junko Odajima et al.   DEVELOPMENTAL CELL

Cyclin-Dependent Kinase 5 Promotes Pancreatic  -Cell Survival via Fak-Akt Signaling Pathways

(2011) M. Daval et al.   DIABETES

Regulation of Androgen Receptor and Prostate Cancer Growth by Cyclin-dependent Kinase 5

(2011) Fu-Ning Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity

(2011) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25

(2011) Ko Sato et al.   JOURNAL OF NEUROCHEMISTRY

Nestin as a regulator of Cdk5 in differentiating myoblasts

(2011) Hanna-Mari Pallari et al.   MOLECULAR BIOLOGY OF THE CELL

Elevation of p-NR2AS1232 by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model

(2011) Jie Chen et al.   NEUROBIOLOGY OF DISEASE

The Role of miR-103 and miR-107 in Regulation of CDK5R1 Expression and in Cellular Migration

(2011) Silvia Moncini et al.   PLoS One

A Cell-Based High-Content Screening Assay Reveals Activators and Inhibitors of Cancer Cell Invasion

(2011) M. Quintavalle et al.   Science Signaling

Membrane Association Facilitates Degradation and Cleavage of the Cyclin-Dependent Kinase 5 Activators p35 and p39

(2010) Seiji Minegishi et al.   BIOCHEMISTRY

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

(2010) Georg Feldmann et al.   CANCER RESEARCH

A 24-Residue Peptide (p5), Derived from p35, the Cdk5 Neuronal Activator, Specifically Inhibits Cdk5-p25 Hyperactivity and Tau Hyperphosphorylation

(2010) Ya-Li Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cdk5 Kinase Regulates the STAT3 Transcription Factor to Prevent DNA Damage upon Topoisomerase I Inhibition

(2010) Sandy Courapied et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

(2010) Amrendra K Ajay et al.   Molecular Cancer

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

(2010) En Huang et al.   NATURE CELL BIOLOGY

Essential Role of Cytoplasmic cdk5 and Prx2 in Multiple Ischemic Injury Models, In Vivo

(2009) J. Rashidian et al.   JOURNAL OF NEUROSCIENCE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

Cdk5-mediated Phosphorylation of c-Myc on Ser-62 Is Essential in Transcriptional Activation of Cyclin B1 by Cyclin G1

(2008) Haeng Ran Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline-dependent kinase 5 complexes

(2008) Akiko Asada et al.   JOURNAL OF NEUROCHEMISTRY