Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

Replication Stress in Mammalian Cells and Its Consequences for Mitosis

(2015) Camille Gelot et al.   Genes

Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors

(2014) N. Haddy et al.   CARCINOGENESIS

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks

(2014) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

(2014) Giuditta Illuzzi et al.   NUCLEIC ACIDS RESEARCH

The causes of replication stress and their consequences on genome stability and cell fate

(2014) Indiana Magdalou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells

(2013) Fu-Ning Hsu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The essential comet assay: a comprehensive guide to measuring DNA damage and repair

(2013) Amaya Azqueta et al.   ARCHIVES OF TOXICOLOGY

Cyclin I is involved in the regulation of cell cycle progression

(2013) Taiki Nagano et al.   CELL CYCLE

CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression

(2013) Qian Liang et al.   Scientific Reports

Replication Checkpoint: Tuning and Coordination of Replication Forks in S Phase

(2013) Nicole Hustedt et al.   Genes

Replication fork dynamics and the DNA damage response

(2012) Rebecca M. Jones et al.   BIOCHEMICAL JOURNAL

Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5

(2012) Abul Arif   BIOCHEMICAL PHARMACOLOGY

Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients

(2012) Zachary Levacque et al.   CELL CYCLE

Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells

(2012) Catherine Le Chalony et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bloom’s Syndrome and PICH Helicases Cooperate with Topoisomerase IIα in Centromere Disjunction before Anaphase

(2012) Sébastien Rouzeau et al.   PLoS One

Genetic Interactions in Cancer Progression and Treatment

(2011) Alan Ashworth et al.   CELL

The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation

(2011) Celeste Bolin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Twice switched at birth: Cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells

(2011) Johanna Liebl et al.   CELLULAR SIGNALLING

Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5

(2011) Erick Contreras-Vallejos et al.   CELLULAR SIGNALLING

Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras

(2011) J. P. Eggers et al.   CLINICAL CANCER RESEARCH

Spi-1/PU.1 Oncogene Accelerates DNA Replication Fork Elongation and Promotes Genetic Instability in the Absence of DNA Breakage

(2010) P. Rimmele et al.   CANCER RESEARCH

The role of RPA2 phosphorylation in homologous recombination in response to replication arrest

(2010) Wei Shi et al.   CARCINOGENESIS

Replication protein A: directing traffic at the intersection of replication and repair

(2010) Greg et al.   Frontiers in Bioscience-Landmark

Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis

(2010) Johanna Liebl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

(2010) Xin Quan Ge et al.   JOURNAL OF CELL BIOLOGY

Expression of CDK5/p35 in resected patients with non-small cell lung cancer: relation to prognosis

(2010) Jun-Li Liu et al.   MEDICAL ONCOLOGY

Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression

(2010) Amrendra K Ajay et al.   Molecular Cancer

The Bloom Syndrome Protein Limits the Lethality Associated with RAD51 Deficiency

(2010) K. Lahkim Bennani-Belhaj et al.   MOLECULAR CANCER RESEARCH

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

(2010) En Huang et al.   NATURE CELL BIOLOGY

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions

(2009) G. Cuny   CURRENT PHARMACEUTICAL DESIGN

The checkpoint response to replication stress

(2009) Dana Branzei et al.   DNA REPAIR

Control of the G2/M checkpoints after exposure to low doses of ionising radiation: Implications for hyper-radiosensitivity

(2009) Marie Fernet et al.   DNA REPAIR

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

(2009) V. M. Vassin et al.   JOURNAL OF CELL SCIENCE

Radiation-induced mitotic catastrophe in PARG-deficient cells

(2009) J.-C. Ame et al.   JOURNAL OF CELL SCIENCE

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

Cell Cycle Regulatory Protein 5 (Cdk5) is a Novel Downstream Target of ERK in Carboplatin Induced Death of Breast Cancer Cells (Supplementary Data)

(2008) Ankur Upadhyay et al.   CURRENT CANCER DRUG TARGETS

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL

The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling

(2008) X. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

(2008) C. Godon et al.   NUCLEIC ACIDS RESEARCH