Targeting CDK6 in cancer: State of the art and new insights

Unexpected Outcomes of CDK4/6 Inhibition

(2015) Yoon Jong Choi et al.   Oncotarget

CDK6 and p16INK4a in lymphoid malignancies

(2015) Karoline Kollmann et al.   Oncotarget

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

(2015) Jorge Franco et al.   Oncotarget

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

(2014) T. Placke et al.   BLOOD

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages

(2014) Lihuan Cao et al.   BMC EVOLUTIONARY BIOLOGY

Abstract 2744: CDK4/CDK6 inhibition is potently active in a definable subset of human neuroblastomas.

(2014) JulieAnn Rader et al.   CANCER RESEARCH

MLL fusion-driven activation ofCDK6potentiates proliferation inMLL-rearranged infant ALL

(2014) Marieke Van der Linden et al.   CELL CYCLE

Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts

(2014) S. C. Tate et al.   CLINICAL CANCER RESEARCH

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

(2014) Lawrence M. Gelbert et al.   INVESTIGATIONAL NEW DRUGS

Early-onset colorectal cancer patients without family history are “at very low risk” for lynch syndrome

(2014) Vittoria Stigliano et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3

(2014) Zhihong Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

(2014) M. V. Ramana Reddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiproliferative Effects of CDK4/6 Inhibition in CDK4-Amplified Human Liposarcoma In Vitro and In Vivo

(2014) Y.-X. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression

(2014) Katja Handschick et al.   MOLECULAR CELL

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

(2013) Karoline Kollmann et al.   CANCER CELL

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: Duration of cell cycle arrest and MTOR activity determine geroconversion

(2013) Olga V. Leontieva et al.   CELL CYCLE

CDK6 binds and promotes the degradation of the EYA2 protein

(2013) Dawn Kohrt et al.   CELL CYCLE

Initiation of MLL-rearranged AML is dependent on C/EBPα

(2013) Ewa Ohlsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

(2013) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Signaling through cyclin D-dependent kinases

(2013) Y J Choi et al.   ONCOGENE

miR-105 Inhibits Prostate Tumour Growth by Suppressing CDK6 Levels

(2013) D. Rice Honeywell et al.   PLoS One

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

(2012) Catherine M. Sawai et al.   CANCER CELL

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy

(2012) A. Kathleen McClendon et al.   CELL CYCLE

miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6

(2012) Xiaolan Zhu et al.   FEBS LETTERS

Sequencing of t(2;7) Translocations Reveals a Consistent Breakpoint Linking CDK6 to the IGK Locus in Indolent B-Cell Neoplasia

(2012) Edward P.K. Parker et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

(2012) L. Cen et al.   NEURO-ONCOLOGY

P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2

(2012) Lei Chen et al.   NEUROSCIENCE LETTERS

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

(2012) Young Shin Cho et al.   ACS Medicinal Chemistry Letters

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Unexpected Reduction of Skin Tumorigenesis on Expression of Cyclin-Dependent Kinase 6 in Mouse Epidermis

(2011) Xian Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression

(2011) Yoshiki Katsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Structural dissection of cyclin dependent kinases regulation and protein recognition properties

(2011) Graziano Lolli   CELL CYCLE

Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo

(2011) Hiroshi Hirai et al.   CELL CYCLE

Expression of p16 and Retinoblastoma Determines Response to CDK4/6 Inhibition in Ovarian Cancer

(2011) Gottfried E. Konecny et al.   CLINICAL CANCER RESEARCH

miR-107 targets cyclin-dependent kinase 6 expression, induces cell cycle G1 arrest and inhibits invasion in gastric cancer cells

(2011) Li Feng et al.   MEDICAL ONCOLOGY

Cdk6-Dependent Regulation of G1 Length Controls Adult Neurogenesis

(2011) Pierre Beukelaers et al.   STEM CELLS

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

Distinct subcellular distribution of cyclin dependent kinase 6

(2010) Dawn Kohrt et al.   CELL CYCLE

miR-129 regulates cell proliferation by downregulating Cdk6 expression

(2010) Junjie Wu et al.   CELL CYCLE

A Distinct Spectrum of Copy Number Aberrations in Pediatric High-Grade Gliomas

(2010) D. A. Bax et al.   CLINICAL CANCER RESEARCH

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Whether to target single or multiple CDKs for therapy? That is the question

(2010) Józefa Węsierska-Gądek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6

(2010) Young Shin Cho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics

(2009) Lindsay O. Kirkland et al.   BIOCHEMICAL PHARMACOLOGY

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis

(2009) M. G. Hu et al.   CANCER RESEARCH

Epigenetic Silencing of MicroRNA miR-107 Regulates Cyclin-Dependent Kinase 6 Expression in Pancreatic Cancer

(2009) Kwang-Hyuck Lee et al.   PANCREATOLOGY

The structure of CDK4/cyclin D3 has implications for models of CDK activation

(2009) T. Takaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of human CDK4 in complex with a D-type cyclin

(2009) P. J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma

(2008) Jessica Pierson et al.   JOURNAL OF NEURO-ONCOLOGY

E2F – at the crossroads of life and death

(2008) Shirley Polager et al.   TRENDS IN CELL BIOLOGY