An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

The type I diabetes association of the IL2RA locus

(2009) H-Q Qu et al.   GENES AND IMMUNITY

PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders

(2009) André Veillette et al.   IMMUNOLOGICAL REVIEWS

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

A cis-Acting Regulatory Variant in the IL2RA Locus

(2009) H.-Q. Qu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice

(2009) M. Araki et al.   JOURNAL OF IMMUNOLOGY

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

(2009) Calliope A Dendrou et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

(2009) Lisa M. Maier et al.   PLoS Genetics

STAT4: Genetics, mechanisms, and implications for autoimmunity

(2008) Benjamin D. Korman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

(2008) H. Hakonarson et al.   DIABETES

Targeted screening of cis-regulatory variation in human haplotypes

(2008) D. J. Verlaan et al.   GENOME RESEARCH

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies

(2008) Dimitry A. Chistiakov et al.   IMMUNOLOGY LETTERS

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25− effector T cells

(2008) Laura Passerini et al.   INTERNATIONAL IMMUNOLOGY

Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells

(2008) S. Alice Long et al.   JOURNAL OF AUTOIMMUNITY

The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice

(2008) Calliope A. Dendrou et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology