GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
Authors
Keywords
Apoptosis, Cytokines, Small interfering RNAs, Diabetes mellitus, Insulin, Alternative splicing, Mitochondria, Gene expression
Journal
PLoS Genetics
Volume 9, Issue 5, Pages e1003532
Publisher
Public Library of Science (PLoS)
Online
2013-05-31
DOI
10.1371/journal.pgen.1003532
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells
- (2012) F Allagnat et al. CELL DEATH AND DIFFERENTIATION
- A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
- (2012) Jalal Taneera et al. Cell Metabolism
- Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human -Cell Apoptosis
- (2012) D. A. Cunha et al. DIABETES
- Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
- (2012) R. Bergholdt et al. DIABETES
- A Genome-Wide Association Study IdentifiesGRK5andRASGRP1as Type 2 Diabetes Loci in Chinese Hans
- (2012) Huaixing Li et al. DIABETES
- Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults
- (2012) Yisheng Yang et al. EMBO Molecular Medicine
- Loss of Pnn expression results in mouse early embryonic lethality and cellular apoptosis through SRSF1-mediated alternative expression of Bcl-xS and ICAD
- (2012) Steve Leu et al. JOURNAL OF CELL SCIENCE
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
- (2012) NATURE GENETICS
- The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells
- (2012) Fabrice Moore et al. PLoS One
- Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes
- (2012) Christiane Winkler et al. PLoS One
- The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
- (2012) Décio L. Eizirik et al. PLoS Genetics
- Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children
- (2011) A. Barker et al. DIABETES
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic -Cell Apoptosis via Regulation of the BH3-Only Protein Bim
- (2011) I. Santin et al. DIABETES
- Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation
- (2011) Jenny Barthson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
- (2011) Yoon Shin Cho et al. NATURE GENETICS
- Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
- (2011) Esteban N. Gurzov et al. TRENDS IN CELL BIOLOGY
- Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
- (2011) Maikel L. Colli et al. PLoS Pathogens
- Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis
- (2010) F Allagnat et al. CELL DEATH AND DIFFERENTIATION
- Genetics of Type 2 Diabetes
- (2010) E. Ahlqvist et al. CLINICAL CHEMISTRY
- Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people
- (2010) T. W. Boesgaard et al. DIABETOLOGIA
- Novel GLIS3 mutations demonstrate an extended multisystem phenotype
- (2010) P Dimitri et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress
- (2010) Esteban N. Gurzov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation
- (2010) Fabrice Moore et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- (2010) Benjamin F Voight et al. NATURE GENETICS
- Genomics, Type 2 Diabetes, and Obesity
- (2010) Mark I. McCarthy NEW ENGLAND JOURNAL OF MEDICINE
- Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
- (2010) Lorella Marselli et al. PLoS One
- Targeting cyclophilin D and the mitochondrial permeability transition enhances -cell survival and prevents diabetes in Pdx1 deficiency
- (2010) K. Fujimoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alternative splicing in multiple sclerosis and other autoimmune diseases
- (2010) Irina Evsyukova et al. RNA Biology
- ER Stress in Pancreatic Cells: The Thin Red Line Between Adaptation and Failure
- (2010) D. L. Eizirik et al. Science Signaling
- Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS
- (2010) C C Jiang et al. Cell Death & Disease
- Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis
- (2009) E N Gurzov et al. CELL DEATH AND DIFFERENTIATION
- Cytokines Interleukin-1 and Tumor Necrosis Factor- Regulate Different Transcriptional and Alternative Splicing Networks in Primary -Cells
- (2009) F. Ortis et al. DIABETES
- Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
- (2009) M. D. McKenzie et al. DIABETES
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic -Cell Apoptosis
- (2009) F. Moore et al. DIABETES
- Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
- (2009) Daniel A. Cunha et al. DIABETES
- Type 1 and type 2 diabetes—chalk and cheese?
- (2009) K. R. Owen et al. DIABETOLOGIA
- No association of multiple type 2 diabetes loci with type 1 diabetes
- (2009) S. M. Raj et al. DIABETOLOGIA
- A murine model of neonatal diabetes mellitus inGlis3-deficient mice
- (2009) Naoki Watanabe et al. FEBS LETTERS
- MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
- (2009) Maikel L. Colli et al. HUMAN MOLECULAR GENETICS
- Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic -Cell Development and Insulin Gene Expression
- (2009) H. S. Kang et al. MOLECULAR AND CELLULAR BIOLOGY
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- The role of inflammation in insulitis and β-cell loss in type 1 diabetes
- (2009) Décio L. Eizirik et al. Nature Reviews Endocrinology
- The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription
- (2009) Yisheng Yang et al. NUCLEIC ACIDS RESEARCH
- Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress
- (2009) Mira M. Sachdeva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exendin-4 Protects -Cells From Interleukin-1 -Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway
- (2008) M. Ferdaoussi et al. DIABETES
- Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes
- (2008) C. Cervin et al. DIABETES
- Initiation and execution of lipotoxic ER stress in pancreatic -cells
- (2008) D. A. Cunha et al. JOURNAL OF CELL SCIENCE
- Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
- (2008) Qun Pan et al. NATURE GENETICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now