CTSH regulates  -cell function and disease progression in newly diagnosed type 1 diabetes patients

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

(2013) M Miani et al.   Cell Death & Disease

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human

(2012) E. Korpos et al.   DIABETES

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters

(2012) Weiya Douglas Lu et al.   JOURNAL OF NEUROCHEMISTRY

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

The PTPN22C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes

(2011) Lotte B Nielsen et al.   BMC Medical Genetics

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients

(2011) Fang Zou et al.   PLoS One

Gene Targeting of the Cysteine Peptidase Cathepsin H Impairs Lung Surfactant in Mice

(2011) Frank Bühling et al.   PLoS One

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and  -cell apoptosis

(2011) L. A. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

(2011) Sushant Bhatnagar et al.   PLoS Genetics

Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer

(2010) Vasilena Gocheva et al.   BIOLOGICAL CHEMISTRY

Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the Type 1 Diabetes Genetics Consortium

(2010) Silke Rosinger et al.   Clinical Trials

Cathepsin H Is an Additional Convertase of Pro-granzyme B

(2010) Michael E. D'Angelo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

New Definition for the Partial Remission Period in Children and Adolescents With Type 1 Diabetes

(2009) H. B. Mortensen et al.   DIABETES CARE

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

(2009) Maikel L. Colli et al.   HUMAN MOLECULAR GENETICS

Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse

(2009) Lianne C. Hsing et al.   JOURNAL OF AUTOIMMUNITY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis

(2009) Henrik B Mortensen et al.   PEDIATRIC DIABETES

Cathepsins: Key modulators of cell death and inflammatory responses

(2008) Sébastien Conus et al.   BIOCHEMICAL PHARMACOLOGY

Cytokines and β-Cell Biology: from Concept to Clinical Translation

(2008) Marc Y. Donath et al.   ENDOCRINE REVIEWS

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS