The activities of amyloids from a structural perspective

Solid-state NMR sequential assignment of an Amyloid-β(1–42) fibril polymorph

(2016) Francesco Ravotti et al.   Biomolecular NMR Assignments

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

The formation, function and regulation of amyloids: insights from structural biology

(2016) M. Landreh et al.   JOURNAL OF INTERNAL MEDICINE

Current and future treatment of amyloid diseases

(2016) M. Ankarcrona et al.   JOURNAL OF INTERNAL MEDICINE

Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets

(2016) Angela B. Soriaga et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Implications for Alzheimer’s disease of an atomic resolution structure of amyloid-β(1–42) fibrils

(2016) David S. Eisenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology of Prions and Prionoids: A Status Report

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

The HET-S/s Prion Motif in the Control of Programmed Cell Death

(2016) Roland Riek et al.   Cold Spring Harbor Perspectives in Biology

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ex vivomammalian prions are formed of paired double helical prion protein fibrils

(2016) Cassandra Terry et al.   Open Biology

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

(2016) Ester Vázquez-Fernández et al.   PLoS Pathogens

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Uncovering the Mechanism of Aggregation of Human Transthyretin

(2015) Lorena Saelices et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM

(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer's disease

(2015) Rodrigo Morales et al.   Scientific Reports

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

(2014) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids

(2014) Bradley R. Groveman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Presence of an Air–Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

(2014) Silvia Campioni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Progress towards structural understanding of infectious sheep PrP-amyloid

(2014) Henrik Müller et al.   Prion

Physical and structural basis for polymorphism in amyloid fibrils

(2014) Robert Tycko   PROTEIN SCIENCE

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Contribution of Specific Residues of the β-Solenoid Fold to HET-s Prion Function, Amyloid Structure and Stability

(2014) Asen Daskalov et al.   PLoS Pathogens

The BRICHOS Domain, Amyloid Fibril Formation, and Their Relationship

(2013) Stefan D. Knight et al.   BIOCHEMISTRY

A Super-Assembly of Whi3 Encodes Memory of Deceptive Encounters by Single Cells during Yeast Courtship

(2013) Fabrice Caudron et al.   CELL

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Elucidating the role of cofactors in mammalian prion propagation

(2013) Surachai Supattapone   Prion

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Acquisition of Drug Resistance and Dependence by Prions

(2013) Anja M. Oelschlegel et al.   PLoS Pathogens

Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

(2012) Laura Pieri et al.   BIOPHYSICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug

(2012) Steven M. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates

(2012) C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

(2012) Carolin Seuring et al.   PLOS BIOLOGY

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Atomic Structures Suggest Determinants of Transmission Barriers in Mammalian Prion Disease

(2011) Marcin I. Apostol et al.   BIOCHEMISTRY

Prions on the move

(2011) Charles Weissmann et al.   EMBO REPORTS

Structural Polymorphism in Amyloids

(2011) Eric M. Jones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Membrane Interaction and Disruption by α-Synuclein

(2011) Nicholas P. Reynolds et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

Molecular basis for amyloid-  polymorphism

(2011) J.-P. Colletier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidimensional Structure-Activity Relationship of a Protein in Its Aggregated States

(2010) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

Crystallographic Studies of Prion Protein (PrP) Segments Suggest How Structural Changes Encoded by Polymorphism at Residue 129 Modulate Susceptibility to Human Prion Disease

(2010) Marcin I. Apostol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vitro Formation of Amyloid from α-Synuclein Is Dominated by Reactions at Hydrophobic Interfaces

(2010) Jeremy Pronchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Darwinian Evolution of Prions in Cell Culture

(2010) J. Li et al.   SCIENCE

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt–Jakob disease: its effect on the phenotype and prion-type characteristics

(2009) Ignazio Cali et al.   BRAIN

Dominant pro-vasopressin mutants that cause diabetes insipidus form disulfide-linked fibrillar aggregates in the endoplasmic reticulum

(2009) J. Birk et al.   JOURNAL OF CELL SCIENCE

The emerging concept of functional amyloid

(2009) C. P. J. Maury   JOURNAL OF INTERNAL MEDICINE

Molecular mechanisms for protein-encoded inheritance

(2009) Jed J W Wiltzius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Molecular basis for insulin fibril assembly

(2009) Magdalena I. Ivanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils

(2008) Jessica Meinhardt et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils

(2008) J. J. Helmus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE