Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Authors
Keywords
-
Journal
eLife
Volume 5, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2016-05-24
DOI
10.7554/elife.12977
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels
- (2016) Thanh D. Do et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- In Vivo Seeding and Cross-Seeding of Localized Amyloidosis
- (2015) Marie E. Oskarsson et al. AMERICAN JOURNAL OF PATHOLOGY
- A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic Acid)
- (2015) Nadine D. Younan et al. BIOCHEMISTRY
- Mechanism of Nucleated Conformational Conversion of Aβ42
- (2015) Ziao Fu et al. BIOCHEMISTRY
- Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
- (2015) Serene W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
- (2015) Dhiman Ghosh et al. Scientific Reports
- Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
- (2014) Benedetta Mannini et al. ACS Chemical Biology
- Significant Structural Differences between Transient Amyloid-β Oligomers and Less-Toxic Fibrils in Regions Known To Harbor Familial Alzheimer′s Mutations
- (2014) Bidyut Sarkar et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils
- (2014) Christofer Lendel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Rationally Designed, Nontoxic, Nonamyloidogenic Analogues of Human Islet Amyloid Polypeptide with Improved Solubility
- (2014) Hui Wang et al. BIOCHEMISTRY
- High Stability and Cooperative Unfolding of α-Synuclein Oligomers
- (2014) Wojciech Paslawski et al. BIOCHEMISTRY
- Diabetes Mellitus and Dementia
- (2014) Toshiharu Ninomiya Current Diabetes Reports
- The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation
- (2014) Nikolai Lorenzen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Association between Amylin and Amyloid-β Peptides in Plasma in the Context of Apolipoprotein E4 Allele
- (2014) Wei Qiao Qiu et al. PLoS One
- General Amyloid Inhibitors? A Critical Examination of the Inhibition of IAPP Amyloid Formation by Inositol Stereoisomers
- (2014) Hui Wang et al. PLoS One
- Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies
- (2014) Yaron Bram et al. Scientific Reports
- Cardioprotection by Controlling Hyperamylinemia in a “Humanized” Diabetic Rat Model
- (2014) Sanda Despa et al. Journal of the American Heart Association
- Systemic Amyloidoses
- (2013) Luis M. Blancas-Mejía et al. Annual Review of Biochemistry
- pH Dependence of Amylin Fibrillization
- (2013) Suman Jha et al. BIOCHEMISTRY
- Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity
- (2013) Ping Cao et al. FEBS LETTERS
- Mechanisms of islet amyloidosis toxicity in type 2 diabetes
- (2013) Andisheh Abedini et al. FEBS LETTERS
- Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors
- (2013) Lydia M. Young et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
- (2013) Frederick J Sheedy et al. NATURE IMMUNOLOGY
- Molecular links between Alzheimer’s disease and diabetes mellitus
- (2013) Y. Yang et al. NEUROSCIENCE
- Unlocked Concanavalin A Forms Amyloid-like Fibrils from Coagulation of Long-lived “Crinkled” Intermediates
- (2013) Valeria Vetri et al. PLoS One
- Distinct Internalization Pathways of Human Amylin Monomers and Its Cytotoxic Oligomers in Pancreatic Cells
- (2013) Saurabh Trikha et al. PLoS One
- Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient -sheet
- (2013) L. E. Buchanan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide
- (2012) Ling-Hsien Tu et al. BIOCHEMISTRY
- Diabetes Mellitus and the β Cell: The Last Ten Years
- (2012) Frances M. Ashcroft et al. CELL
- The Amyloid State of Proteins in Human Diseases
- (2012) David Eisenberg et al. CELL
- Characterizing the assembly behaviors of human amylin: a perspective derived from C-terminal variants
- (2012) Mei-Sha Chen et al. CHEMICAL COMMUNICATIONS
- Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes
- (2012) Sanda Despa et al. CIRCULATION RESEARCH
- Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology
- (2012) Ping Cao et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide
- (2012) Y. J. Park et al. DIABETOLOGIA
- The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug
- (2012) Steven M. Johnson et al. JOURNAL OF MOLECULAR BIOLOGY
- Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide
- (2012) Nathaniel G.N. Milton et al. MICRON
- Conserved features of intermediates in amyloid assembly determine their benign or toxic states
- (2012) R. Krishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toxic fibrillar oligomers of amyloid- have cross- structure
- (2012) J. C. Stroud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atomic View of a Toxic Amyloid Small Oligomer
- (2012) Arthur Laganowsky et al. SCIENCE
- Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective
- (2011) Jeffrey R. Brender et al. ACCOUNTS OF CHEMICAL RESEARCH
- Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets
- (2011) K. Aston-Mourney et al. DIABETOLOGIA
- Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide
- (2011) Mazin Magzoub et al. FASEB JOURNAL
- Insights into the Mechanism of Aggregation and Fibril Formation from Bovine Serum Albumin
- (2011) Mily Bhattacharya et al. JOURNAL OF PHYSICAL CHEMISTRY B
- 2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-Sheet Structure
- (2011) Lu Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
- (2011) Jan Bieschke et al. Nature Chemical Biology
- Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
- (2011) Per Westermark et al. PHYSIOLOGICAL REVIEWS
- ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
- (2010) Benedetta Bolognesi et al. ACS Chemical Biology
- Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association
- (2010) Erika Andreetto et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Is type 2 diabetes an amyloidosis and does it really matter (to patients)?
- (2010) G. J. S. Cooper et al. DIABETOLOGIA
- Residue-Specific, Real-Time Characterization of Lag-Phase Species and Fibril Growth During Amyloid Formation: A Combined Fluorescence and IR Study of p-Cyanophenylalanine Analogs of Islet Amyloid Polypeptide
- (2010) Peter Marek et al. JOURNAL OF MOLECULAR BIOLOGY
- Combination of Kinetically Selected Inhibitorsin TransLeads to Highly Effective Inhibition of Amyloid Formation
- (2010) Fanling Meng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Residue-specific structural kinetics of proteins through the union of isotope labeling, mid-IR pulse shaping, and coherent 2D IR spectroscopy
- (2010) Chris T. Middleton et al. METHODS
- A causative link between the structure of aberrant protein oligomers and their toxicity
- (2010) Silvia Campioni et al. Nature Chemical Biology
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Efficient Microwave-Assisted Synthesis of Human Islet Amyloid Polypeptide Designed to Facilitate the Specific Incorporation of Labeled Amino Acids
- (2010) Peter Marek et al. ORGANIC LETTERS
- Stabilization of neurotoxic Alzheimer amyloid- oligomers by protein engineering
- (2010) A. Sandberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts
- (2010) K. J. Potter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evidence for Proteotoxicity in β Cells in Type 2 Diabetes
- (2009) Tatyana Gurlo et al. AMERICAN JOURNAL OF PATHOLOGY
- Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
- (2009) R. L. Hull et al. DIABETOLOGIA
- Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis
- (2009) S. Zraika et al. DIABETOLOGIA
- Characterization of Oligomeric Species on the Aggregation Pathway of Human Lysozyme
- (2009) Erica Frare et al. JOURNAL OF MOLECULAR BIOLOGY
- Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide
- (2009) Jessica A. Williamson et al. JOURNAL OF MOLECULAR BIOLOGY
- Strategies for Extracting Structural Information from 2D IR Spectroscopy of Amyloid: Application to Islet Amyloid Polypeptide
- (2009) David B. Strasfeld et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Human Islet Amyloid Polypeptide Monomers Form Ordered β-hairpins: A Possible Direct Amyloidogenic Precursor
- (2009) Nicholas F. Dupuis et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural Properties of Pore-Forming Oligomers of α-Synuclein
- (2009) Hai-Young Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process
- (2009) Jed J. W. Wiltzius et al. PROTEIN SCIENCE
- Structural Classification of Toxic Amyloid Oligomers
- (2008) Charles G. Glabe JOURNAL OF BIOLOGICAL CHEMISTRY
- Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
- (2008) Judith Miklossy et al. NEUROBIOLOGY OF AGING
- Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets
- (2008) Gunilla T. Westermark et al. NEW ENGLAND JOURNAL OF MEDICINE
- Extrinsic Fluorescent Dyes as Tools for Protein Characterization
- (2008) Andrea Hawe et al. PHARMACEUTICAL RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started