Uncovering the Mechanism of Aggregation of Human Transthyretin

Recent progress in the understanding and treatment of transthyretin amyloidosis

(2014) Y. Sekijima   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Effect of Proline Mutations on the Monomer Conformations of Amylin

(2013) Chi-cheng Chiu et al.   BIOPHYSICAL JOURNAL

Localized Structural Fluctuations Promote Amyloidogenic Conformations in Transthyretin

(2013) Kwang Hun Lim et al.   JOURNAL OF MOLECULAR BIOLOGY

Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis

(2013) Yohei Misumi et al.   LABORATORY INVESTIGATION

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS

(2013) M. I. Ivanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

(2013) Lin Jiang et al.   eLife

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

(2012) Heiko Kroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial

(2012) T. Coelho et al.   NEUROLOGY

Distinct Annular Oligomers Captured along the Assembly and Disassembly Pathways of Transthyretin Amyloid Protofibrils

(2012) Ricardo H. Pires et al.   PLoS One

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Molecular basis for amyloid-  polymorphism

(2011) J.-P. Colletier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

(2011) M. M. Alhamadsheh et al.   Science Translational Medicine

Identifying the amylome, proteins capable of forming amyloid-like fibrils

(2010) Lukasz Goldschmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

An in vitro selection strategy for conferring protease resistance to ligand binding peptides

(2009) B. Eldridge et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation

(2008) Tsuyoshi Takahashi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Quantification of the Thermodynamically Linked Quaternary and Tertiary Structural Stabilities of Transthyretin and Its Disease-Associated Variants: The Relationship between Stability and Amyloidosis†

(2008) Amy R. Hurshman Babbes et al.   BIOCHEMISTRY

Structural Insight into pH-Induced Conformational Changes within the Native Human Transthyretin Tetramer

(2008) Satheesh K. Palaninathan et al.   JOURNAL OF MOLECULAR BIOLOGY