Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Authors
Keywords
-
Journal
PLoS Pathogens
Volume 19, Issue 10, Pages e1011601
Publisher
Public Library of Science (PLoS)
Online
2023-10-31
DOI
10.1371/journal.ppat.1011601
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Recent updates on correlates of vaccine-induced protection
- (2023) Stanley A. Plotkin Frontiers in Immunology
- Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
- (2023) Philippe Colin et al. Retrovirology
- Divide and conquer: broadly neutralizing antibody combinations for improved HIV-1 viral coverage
- (2023) Kshitij Wagh et al. Current Opinion in HIV and AIDS
- Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations
- (2023) Edwin J. Heeregrave et al. Frontiers in Immunology
- Glycosylation as a key parameter in the design of nucleic acid vaccines
- (2022) Ahmet Ozdilek et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2
- (2022) Evan M. Cale et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reappraising the Value of HIV-1 Vaccine Correlates of Protection Analyses
- (2022) P. J. Klasse et al. JOURNAL OF VIROLOGY
- Structural Dynamics Reveal Isolate-specific Differences at Neutralization Epitopes on HIV Env
- (2022) Edgar A. Hodge et al. iScience
- Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1
- (2022) Colin LaMont et al. eLife
- Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition
- (2022) Peter B. Gilbert et al. NATURE MEDICINE
- Immunogenicity of clinically relevant SARS-CoV-2 vaccines in non-human primates and humans
- (2021) P. J. Klasse et al. Science Advances
- Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition
- (2021) Lawrence Corey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike
- (2021) Ronald Derking et al. Cell Reports
- Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constants
- (2021) Georges Vauquelin et al. Pharmacology Research & Perspectives
- The Glycan Hole Area of HIV-1 Envelope Trimers Contributes Prominently to the Induction of Autologous Neutralization
- (2021) Anna Schorcht et al. JOURNAL OF VIROLOGY
- Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis
- (2021) Deborah Cromer et al. Lancet Microbe
- Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?
- (2020) P.J. Klasse et al. Cell Host & Microbe
- Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions
- (2020) Gemma E. Seabright et al. STRUCTURE
- SARS-CoV-2 vaccines in development
- (2020) Florian Krammer NATURE
- Visualization of the HIV-1 Env glycan shield across scales
- (2020) Zachary T. Berndsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leginon: New Features and Applications
- (2020) Anchi Cheng et al. PROTEIN SCIENCE
- Protein and Glycan Mimicry in HIV Vaccine Design
- (2019) Gemma E. Seabright et al. JOURNAL OF MOLECULAR BIOLOGY
- Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques
- (2019) Amelia Escolano et al. NATURE
- Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic
- (2019) Marina Caskey et al. NATURE MEDICINE
- Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics
- (2019) Alba Torrents de la Peña et al. PLoS Pathogens
- A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge
- (2019) Amarendra Pegu et al. Cell Host & Microbe
- Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy
- (2019) Ajith Kumar et al. BIOCHEMISTRY
- Current Developments in Coot for Macromolecular Model Building of Electron Cryo‐microscopy and Crystallographic Data
- (2019) Ana Casañal et al. PROTEIN SCIENCE
- Multiple roles for HIV broadly neutralizing antibodies
- (2019) Barton F. Haynes et al. Science Translational Medicine
- Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
- (2019) Philip J. M. Brouwer et al. Nature Communications
- Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin
- (2019) Rajesh P. Ringe et al. JOURNAL OF VIROLOGY
- Broadly neutralizing antibodies for the treatment and prevention of HIV infection
- (2019) Marina Caskey Current Opinion in HIV and AIDS
- Harnessing post-translational modifications for next-generation HIV immunogens
- (2018) Joel D. Allen et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure
- (2018) Peter D. Kwong et al. IMMUNITY
- Global site-specific analysis of glycoprotein N-glycan processing
- (2018) Liwei Cao et al. Nature Protocols
- Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections
- (2018) Kshitij Wagh et al. PLoS Pathogens
- Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques
- (2018) P. J. Klasse et al. PLoS Pathogens
- Real-space refinement in PHENIX for cryo-EM and crystallography
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions
- (2018) Beth M. Stadtmueller et al. IMMUNITY
- Combination therapy with anti-HIV-1 antibodies maintains viral suppression
- (2018) Pilar Mendoza et al. NATURE
- Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
- (2018) Liwei Cao et al. Nature Communications
- Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen
- (2018) Weston B. Struwe et al. Cell Reports
- Recent progress in broadly neutralizing antibodies to HIV
- (2018) Devin Sok et al. NATURE IMMUNOLOGY
- Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1
- (2017) Anna-Janina Behrens et al. Expert Review of Proteomics
- A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
- (2017) Jeong Hyun Lee et al. IMMUNITY
- Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop
- (2017) Evan M. Cale et al. IMMUNITY
- The HIV-1 envelope glycoprotein structure: nailing down a moving target
- (2017) Andrew B Ward et al. IMMUNOLOGICAL REVIEWS
- Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes
- (2017) Rajesh P. Ringe et al. JOURNAL OF VIROLOGY
- Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells
- (2017) Yehuda Z. Cohen et al. JOURNAL OF VIROLOGY
- Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike
- (2017) Gabriel Ozorowski et al. NATURE
- Antibody 10-1074 suppresses viremia in HIV-1-infected individuals
- (2017) Marina Caskey et al. NATURE MEDICINE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- What Are the Most Powerful Immunogen Design Vaccine Strategies?
- (2017) Dennis R. Burton Cold Spring Harbor Perspectives in Biology
- Global site-specific N-glycosylation analysis of HIV envelope glycoprotein
- (2017) Liwei Cao et al. Nature Communications
- Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters
- (2017) Oliver F. Brandenberg et al. PLoS Pathogens
- Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G
- (2016) Guillaume B.E. Stewart-Jones et al. CELL
- Towards HIV-1 remission: potential roles for broadly neutralizing antibodies
- (2016) Ariel Halper-Stromberg et al. JOURNAL OF CLINICAL INVESTIGATION
- Progress toward active or passive HIV-1 vaccination
- (2016) Amelia Escolano et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual
- (2016) Karen P. Coss et al. JOURNAL OF VIROLOGY
- Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer
- (2016) Anna-Janina Behrens et al. JOURNAL OF VIROLOGY
- HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption
- (2016) Johannes F. Scheid et al. NATURE
- Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption
- (2016) Katharine J. Bar et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen
- (2016) Leopold Kong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop
- (2016) Haoqing Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer
- (2016) J. H. Lee et al. SCIENCE
- Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
- (2016) R. Kong et al. SCIENCE
- Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein
- (2016) Anna-Janina Behrens et al. Cell Reports
- Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
- (2016) Kshitij Wagh et al. PLoS Pathogens
- Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C
- (2016) P. J. Klasse et al. PLoS Pathogens
- An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability
- (2016) Marit J. van Gils et al. Nature Microbiology
- Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein
- (2015) Marina R. Alexander et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance
- (2015) Laura K. Pritchard et al. JOURNAL OF VIROLOGY
- Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers
- (2015) Rajesh P. Ringe et al. JOURNAL OF VIROLOGY
- A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype BenvGene
- (2015) Pavel Pugach et al. JOURNAL OF VIROLOGY
- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- HIV-1 assembly, release and maturation
- (2015) Eric O. Freed NATURE REVIEWS MICROBIOLOGY
- Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers
- (2015) Laura K. Pritchard et al. Cell Reports
- Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer
- (2015) Ronald Derking et al. PLoS Pathogens
- Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
- (2015) Laura E. McCoy et al. PLoS Pathogens
- Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
- (2014) Emilia Falkowska et al. IMMUNITY
- Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
- (2014) Claudia Blattner et al. IMMUNITY
- Two Classes of Broadly Neutralizing Antibodies within a Single Lineage Directed to the High-Mannose Patch of HIV Envelope
- (2014) Katie J. Doores et al. JOURNAL OF VIROLOGY
- Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single-Particle Electron Microscopy
- (2014) C. D. Murin et al. JOURNAL OF VIROLOGY
- Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
- (2014) Jinghe Huang et al. NATURE
- Structure and immune recognition of trimeric pre-fusion HIV-1 Env
- (2014) Marie Pancera et al. NATURE
- Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
- (2014) Anila Yasmeen et al. Retrovirology
- Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
- (2013) Leopold Kong et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Relaxation of backbone bond geometry improves protein energy landscape modeling
- (2013) Patrick Conway et al. PROTEIN SCIENCE
- Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer
- (2013) J.-P. Julien et al. SCIENCE
- Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
- (2013) D. Lyumkis et al. SCIENCE
- Antibodies in HIV-1 Vaccine Development and Therapy
- (2013) F. Klein et al. SCIENCE
- A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
- (2013) Rogier W. Sanders et al. PLoS Pathogens
- Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers
- (2012) Rafael S. Depetris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Virus Neutralization and the Persistent Fraction by TRIM21
- (2012) W. A. McEwan et al. JOURNAL OF VIROLOGY
- Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
- (2012) Jinghe Huang et al. NATURE
- Vertebrate protein glycosylation: diversity, synthesis and function
- (2012) Kelley W. Moremen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation
- (2011) Mary Ann Checkley et al. JOURNAL OF MOLECULAR BIOLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding
- (2011) J. F. Scheid et al. SCIENCE
- Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors
- (2011) Thomas J. Ketas et al. VIROLOGY
- Correlates of Protection Induced by Vaccination
- (2010) S. A. Plotkin Clinical and Vaccine Immunology
- Breadth of Neutralizing Antibodies Elicited by Stable, Homogeneous Clade A and Clade C HIV-1 gp140 Envelope Trimers in Guinea Pigs
- (2010) J. P. Nkolola et al. JOURNAL OF VIROLOGY
- Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16
- (2010) Katie J. Doores et al. JOURNAL OF VIROLOGY
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
- (2010) T. Zhou et al. SCIENCE
- Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
- (2010) X. Wu et al. SCIENCE
- Cohen's Conjecture, Howard's Hypothesis, and Ptashne's Ptruth: an exploration of the relationship between affinity and specificity
- (2010) Neil S. Greenspan TRENDS IN IMMUNOLOGY
- Few and Far Between: How HIV May Be Evading Antibody Avidity
- (2010) Joshua S. Klein et al. PLoS Pathogens
- Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
- (2009) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- Appion: An integrated, database-driven pipeline to facilitate EM image processing
- (2009) Gabriel C. Lander et al. JOURNAL OF STRUCTURAL BIOLOGY
- Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
- (2009) M. S. Seaman et al. JOURNAL OF VIROLOGY
- Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10
- (2009) J. S. Klein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Estimating the Stoichiometry of Human Immunodeficiency Virus Entry
- (2008) C. Magnus et al. JOURNAL OF VIROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started