Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
Published 2016 View Full Article
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Title
Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
Authors
Keywords
HIV-1, Antibodies, Antiretrovirals, Complement system, Immunotherapy, Blood plasma, Microbial genetics, Pharmacokinetics
Journal
PLoS Pathogens
Volume 12, Issue 3, Pages e1005520
Publisher
Public Library of Science (PLoS)
Online
2016-03-31
DOI
10.1371/journal.ppat.1005520
References
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Note: Only part of the references are listed.- Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
- (2015) Tongqing Zhou et al. CELL
- Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance
- (2015) Laura K. Pritchard et al. JOURNAL OF VIROLOGY
- Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection
- (2015) Kevin O. Saunders et al. JOURNAL OF VIROLOGY
- Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
- (2015) Marina Caskey et al. NATURE
- Dose–response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies
- (2015) Nicholas E. Webb et al. Nature Communications
- Strategies to guide the antibody affinity maturation process
- (2015) Nicole A Doria-Rose et al. Current Opinion in Virology
- Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
- (2015) Laura E. McCoy et al. PLoS Pathogens
- Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity
- (2014) Stylianos Bournazos et al. CELL
- Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice
- (2014) Ariel Halper-Stromberg et al. CELL
- Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
- (2014) Anthony P. West et al. CELL
- Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
- (2014) Emilia Falkowska et al. IMMUNITY
- Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers
- (2014) Claudia Blattner et al. IMMUNITY
- Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants
- (2014) Florian Klein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes
- (2014) Rui Kong et al. JOURNAL OF VIROLOGY
- Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo
- (2014) R. S. Rudicell et al. JOURNAL OF VIROLOGY
- Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
- (2014) Jinghe Huang et al. NATURE
- Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
- (2014) Sung-Youl Ko et al. NATURE
- Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
- (2014) Nicole A. Doria-Rose et al. NATURE
- Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity
- (2014) R. Cimbro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
- (2014) Devin Sok et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunologic strategies for HIV-1 remission and eradication
- (2014) D. H. Barouch et al. SCIENCE
- Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
- (2014) A. Pegu et al. Science Translational Medicine
- Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV
- (2014) D. Sok et al. Science Translational Medicine
- Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike
- (2014) Louise Scharf et al. Cell Reports
- Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization
- (2014) Arthur S. Kim et al. PLoS Pathogens
- Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
- (2013) Tongqing Zhou et al. IMMUNITY
- HIV-1 neutralizing antibodies: understanding nature's pathways
- (2013) John R. Mascola et al. IMMUNOLOGICAL REVIEWS
- Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1
- (2013) Marcella Sarzotti-Kelsoe et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
- (2013) Hua-Xin Liao et al. NATURE
- Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16
- (2013) Marie Pancera et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
- (2013) Leopold Kong et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
- (2013) J. A. Horwitz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
- (2013) Jean-Philippe Julien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibodies in HIV-1 Vaccine Development and Therapy
- (2013) F. Klein et al. SCIENCE
- Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
- (2013) Jean-Philippe Julien et al. PLoS Pathogens
- A Blueprint for HIV Vaccine Discovery
- (2012) Dennis R. Burton et al. Cell Host & Microbe
- Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies
- (2012) Peter D. Kwong et al. IMMUNITY
- Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
- (2012) Florian Klein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection
- (2012) L. Goo et al. JOURNAL OF VIROLOGY
- HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes
- (2012) N. A. Doria-Rose et al. JOURNAL OF VIROLOGY
- Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
- (2012) Jinghe Huang et al. NATURE
- HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
- (2012) Florian Klein et al. NATURE
- B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
- (2012) Barton F Haynes et al. NATURE BIOTECHNOLOGY
- A quantitative basis for antiretroviral therapy for HIV-1 infection
- (2012) Benjamin L Jilek et al. NATURE MEDICINE
- Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
- (2012) B. Moldt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
- (2012) H. Mouquet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
- (2011) Jason S. McLellan et al. NATURE
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
- (2011) X. Wu et al. SCIENCE
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- (2011) J. F. Scheid et al. SCIENCE
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- Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors
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- The Role of Antibodies in HIV Vaccines
- (2010) John R. Mascola et al. Annual Review of Immunology
- Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1
- (2010) M. Pancera et al. JOURNAL OF VIROLOGY
- Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16
- (2010) Katie J. Doores et al. JOURNAL OF VIROLOGY
- Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals
- (2010) Davide Corti et al. PLoS One
- Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
- (2010) R. Pejchal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
- (2010) T. Zhou et al. SCIENCE
- Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
- (2010) X. Wu et al. SCIENCE
- Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
- (2009) M. S. Seaman et al. JOURNAL OF VIROLOGY
- Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
- (2009) Johannes F. Scheid et al. NATURE
- Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
- (2009) Ann J Hessell et al. NATURE MEDICINE
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- A method for identification of HIV gp140 binding memory B cells in human blood
- (2008) Johannes F. Scheid et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
- (2008) Lin Shen et al. NATURE MEDICINE
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