A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
Authors
Keywords
-
Journal
PLoS Pathogens
Volume 9, Issue 9, Pages e1003618
Publisher
Public Library of Science (PLoS)
Online
2013-09-20
DOI
10.1371/journal.ppat.1003618
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- HIV-1 envelope trimer has similar binding characteristics for carbohydrate-binding agents as monomeric gp120
- (2013) Bart Hoorelbeke et al. FEBS LETTERS
- HIV-1 Envelope Glycoprotein Trimers Display Open Quaternary Conformation When Bound to the gp41 Membrane-Proximal External-Region-Directed Broadly Neutralizing Antibody Z13e1
- (2013) A. K. Harris et al. JOURNAL OF VIROLOGY
- Structural Characterization of Cleaved, Soluble HIV-1 Envelope Glycoprotein Trimers
- (2013) R. Khayat et al. JOURNAL OF VIROLOGY
- Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein
- (2013) P. J. Klasse et al. JOURNAL OF VIROLOGY
- Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes
- (2013) S. Hoffenberg et al. JOURNAL OF VIROLOGY
- Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
- (2013) Leopold Kong et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
- (2013) Jean-Philippe Julien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution
- (2013) Daniel P. Leaman et al. PLoS Pathogens
- Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
- (2013) Jean-Philippe Julien et al. PLoS Pathogens
- Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers
- (2012) Rafael S. Depetris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
- (2012) Florian Klein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials
- (2012) D. C. Montefiori et al. JOURNAL OF INFECTIOUS DISEASES
- HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120
- (2012) James M. Kovacs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Broadly neutralizing antibodies against HIV-1: Templates for a vaccine
- (2012) Marit J. van Gils et al. VIROLOGY
- Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
- (2012) Erin E. H. Tran et al. PLoS Pathogens
- Clinical evaluation of a soluble trimeric HIV-1 envelope glycoprotein vaccine
- (2011) Rogier W Sanders Expert Review of Vaccines
- A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers
- (2011) Paul Spearman et al. JOURNAL OF INFECTIOUS DISEASES
- An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum
- (2011) G. Ferrari et al. JOURNAL OF VIROLOGY
- Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses
- (2011) M. Melchers et al. JOURNAL OF VIROLOGY
- Binding Interactions between Soluble HIV Envelope Glycoproteins and Quaternary-Structure-Specific Monoclonal Antibodies PG9 and PG16
- (2011) T. M. Davenport et al. JOURNAL OF VIROLOGY
- Broad neutralization coverage of HIV by multiple highly potent antibodies
- (2011) Laura M. Walker et al. NATURE
- The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade
- (2011) Camille Bonomelli et al. PLoS One
- Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures
- (2011) A. Harris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
- (2011) Mark Melchers et al. Retrovirology
- A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
- (2011) R. Pejchal et al. SCIENCE
- Naturally Occurring Variability in the Envelope Glycoprotein of HIV-1 and Development of Cell Entry Inhibitors
- (2010) Evan T. Brower et al. BIOCHEMISTRY
- Stabilized HIV-1 Envelope Glycoprotein Trimers Lacking the V1V2 Domain, Obtained by Virus Evolution
- (2010) Ilja Bontjer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A clustering approach to multireference alignment of single-particle projections in electron microscopy
- (2010) C.O.S. Sorzano et al. JOURNAL OF STRUCTURAL BIOLOGY
- Conformational characterization of aberrant disulfide-linked HIV-1 gp120 dimers secreted from overexpressing cells
- (2010) Andrés Finzi et al. JOURNAL OF VIROLOGICAL METHODS
- Breadth of Neutralizing Antibodies Elicited by Stable, Homogeneous Clade A and Clade C HIV-1 gp140 Envelope Trimers in Guinea Pigs
- (2010) J. P. Nkolola et al. JOURNAL OF VIROLOGY
- Local Conformational Stability of HIV-1 gp120 in Unliganded and CD4-Bound States as Defined by Amide Hydrogen/Deuterium Exchange
- (2010) L. Kong et al. JOURNAL OF VIROLOGY
- Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function
- (2010) Dirk Eggink et al. VIROLOGY
- Detailed Mechanistic Insights into HIV-1 Sensitivity to Three Generations of Fusion Inhibitors
- (2009) Dirk Eggink et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Appion: An integrated, database-driven pipeline to facilitate EM image processing
- (2009) Gabriel C. Lander et al. JOURNAL OF STRUCTURAL BIOLOGY
- DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy
- (2009) N.R. Voss et al. JOURNAL OF STRUCTURAL BIOLOGY
- Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
- (2009) L. M. Walker et al. SCIENCE
- Biochemical and biophysical comparison of cleaved and uncleaved soluble, trimeric HIV-1 envelope glycoproteins
- (2009) Antu K. Dey et al. VIROLOGY
- Immunogenicity of HIV-1 envelope glycoprotein oligomers
- (2009) Mattias NE Forsell et al. Current Opinion in HIV and AIDS
- Experimental Approaches to Evaluate the Thermodynamics of Protein- Drug Interactions
- (2008) Walter de Azevedo Jr. et al. CURRENT DRUG TARGETS
- Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
- (2008) I. Bontjer et al. JOURNAL OF VIROLOGY
- Molecular architecture of native HIV-1 gp120 trimers
- (2008) Jun Liu et al. NATURE
- Enhancing Exposure of HIV-1 Neutralization Epitopes through Mutations in gp41
- (2007) Catherine A Blish et al. PLOS MEDICINE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started