What Are the Most Powerful Immunogen Design Vaccine Strategies?

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

(2016) Dennis R. Burton et al.   Annual Review of Immunology

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

(2016) Bryan Briney et al.   CELL

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

(2016) Amelia Escolano et al.   CELL

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

(2016) Ming Tian et al.   CELL

Antibody-guided vaccine design: identification of protective epitopes

(2016) Antonio Lanzavecchia et al.   CURRENT OPINION IN IMMUNOLOGY

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans

(2016) Devin Sok et al.   IMMUNITY

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

(2016) Rino Rappuoli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

(2016) D. Sok et al.   SCIENCE

Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system

(2015) Irmgard Hofmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

(2015) Shenshen Wang et al.   CELL

New approaches to HIV vaccine development

(2015) Barton F Haynes   CURRENT OPINION IN IMMUNOLOGY

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Insights into the trimeric HIV-1 envelope glycoprotein structure

(2015) Andrew B. Ward et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

(2014) Nicole A. Doria-Rose et al.   NATURE

Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies

(2014) Anna Kabanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

(2014) D. Sok et al.   Science Translational Medicine

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

(2013) Tongqing Zhou et al.   IMMUNITY

Cross-neutralization of four paramyxoviruses by a human monoclonal antibody

(2013) Davide Corti et al.   NATURE

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Immunization of Macaques With Soluble HIV Type 1 and Influenza Virus Envelope Glycoproteins Results in a Similarly Rapid Contraction of Peripheral B-Cell Responses After Boosting

(2012) Christopher Sundling, Paola Martinez, Martina Soldemo, Mats Spångberg, Karin Lövgren Bengtsson, Linda Stertman, Mattias N. E. Forsell et al.   JOURNAL OF INFECTIOUS DISEASES

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

(2012) H. Mouquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses

(2012) D. R. Burton et al.   SCIENCE

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

(2009) Xiaodong Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

(2009) A. Macagno et al.   JOURNAL OF VIROLOGY