Glaucoma: neuroprotection with NAD-based therapeutic interventions

NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies

(2023) Andrea Loreto et al.   NEUROSCIENCE RESEARCH

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

(2023) James R. Tribble et al.   Acta Neuropathologica Communications

Correction: A duplex structure of SARM1 octamers stabilized by a new inhibitor

(2023) Tami Khazma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies

(2023) Pingting Liu et al.   Molecular Therapy-Nucleic Acids

A Systematic Review of Glaucoma Diagnosis in Prevalence Studies and Quality of Reporting

(2023) Zayn Al-Timimi et al.   JOURNAL OF GLAUCOMA

Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering

(2023) James R. Tribble et al.   MOLECULAR ASPECTS OF MEDICINE

Nicotinamide enhances natural killer cell function and yields remissions in patients with non-Hodgkin lymphoma

(2023) Frank Cichocki et al.   Science Translational Medicine

Astrocytes in the Optic Nerve Are Heterogeneous in Their Reactivity to Glaucomatous Injury

(2023) Ying Zhu et al.   Cells

Glaucoma -‘a Stiff Eye in a Stiff Body’

(2022) Sarah Powell et al.   CURRENT EYE RESEARCH

Nicotinamide riboside as a neuroprotective therapy for glaucoma: study protocol for a randomized, double-blind, placebo-control trial

(2022) Christopher Kai Shun Leung et al.   Trials

Oral nicotinamide for non-melanoma skin cancers: A review

(2022) Samantha Vicki Hunt et al.   EYE

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules

(2022) Yun Shi et al.   MOLECULAR CELL

The chemical biology of NAD+ regulation in axon degeneration

(2022) Janneke D. Icso et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism

(2022) Tamara Maric et al.   BIOSENSORS & BIOELECTRONICS

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease

(2022) Matthew Bratkowski et al.   NEURON

The therapeutic potential of berberine chloride against SARM1 ‐dependent axon degeneration in acrylamide‐induced neuropathy

(2022) Shuai Wang et al.   PHYTOTHERAPY RESEARCH

Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies

(2022) Borut Poljšak et al.   Antioxidants

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

(2021) Robert O. Hughes et al.   Cell Reports

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

The Key Role of NAD+ in Anti-Tumor Immune Response: An Update

(2021) Fabio Morandi et al.   Frontiers in Immunology

Mechanisms of organelle elimination for lens development and differentiation

(2021) Lisa Brennan et al.   EXPERIMENTAL EYE RESEARCH

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

(2021) Yuetong Wang et al.   Cell Reports

Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration

(2021) Andrew M. Boal et al.   Cells

Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage

(2021) Xian Zhang et al.   Pharmaceutics

The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions

(2021) Carlo Fortunato et al.   IUBMB LIFE

Association between Daily Niacin Intake and Glaucoma: National Health and Nutrition Examination Survey

(2021) Teerajet Taechameekietichai et al.   Nutrients

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma

(2021) Carlos Gustavo De Moraes et al.   JAMA Ophthalmology

Programmed axon degeneration: from mouse to mechanism to medicine

(2020) Michael P. Coleman et al.   NATURE REVIEWS NEUROSCIENCE

The Role of Lamina Cribrosa Tissue Stiffness and Fibrosis as Fundamental Biomechanical Drivers of Pathological Glaucomatous Cupping

(2020) Alan A Hopkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3 ) supplementation: A crossover randomized clinical trial

(2020) Flora Hui et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

(2020) Matthew D Figley et al.   CURRENT OPINION IN NEUROBIOLOGY

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

(2020) Kwang Woo Ko et al.   JOURNAL OF CELL BIOLOGY

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

(2020) Ema Ozaki et al.   Life Science Alliance

Identification of the first noncompetitive SARM1 inhibitors

(2020) Heather S. Loring et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potential Therapeutic Benefit of NAD+ Supplementation for Glaucoma and Age-Related Macular Degeneration

(2020) Gloria Cimaglia et al.   Nutrients

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

(2020) Jeffrey M. Harder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution and Progression of Visual Field Defects with Binocular Vision in Glaucoma

(2018) Shigeki Hashimoto et al.   JOURNAL OF GLAUCOMA

Oral Memantine for the Treatment of Glaucoma

(2018) Robert N. Weinreb et al.   OPHTHALMOLOGY

Glaucoma as a Metabolic Optic Neuropathy

(2017) Pete A. Williams et al.   JOURNAL OF GLAUCOMA

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

(2017) Pete A. Williams et al.   Frontiers in Neuroscience

Neuroprotection in Glaucoma: Animal Models and Clinical Trials

(2017) Mohammadali Almasieh et al.   Annual Review of Vision Science

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

(2015) Andrew C. Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability

(2013) Dao-Yi Yu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

(2012) Gareth R. Howell et al.   EXPERIMENTAL NEUROLOGY

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

Wallerian Degeneration, WldS, and Nmnat

(2010) Michael P. Coleman et al.   Annual Review of Neuroscience