The therapeutic potential of berberine chloride against SARM1 ‐dependent axon degeneration in acrylamide‐induced neuropathy

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

(2022) A. Joseph Bloom et al.   Molecular Neurodegeneration

SARM1 can be a potential therapeutic target for spinal cord injury

(2022) Qicheng Lu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

(2021) Robert O. Hughes et al.   Cell Reports

Co-Delivery of Berberine Chloride and Tariquidar in Nanoliposomes Enhanced Intracellular Berberine Chloride in a Doxorubicin-Resistant K562 Cell Line Due to P-gp Overexpression

(2021) Giulia Vanti et al.   Pharmaceutics

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

(2021) Todd Bosanac et al.   BRAIN

Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures

(2021) Donald V. Bradshaw et al.   Acta Neuropathologica Communications

Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice

(2021) Jing Zhao et al.   Frontiers in Pharmacology

A Review of Dietary Intake of Acrylamide in Humans

(2021) Clara Amalie Gade Timmermann et al.   Toxics

Oral administration of berberine limits post-traumatic osteoarthritis development and associated pain via AMP-activated protein kinase (AMPK) in mice

(2021) J. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

(2021) Stacey Anne Gould et al.   Cell Reports

Acrylamide in coffee: formation and possible mitigation strategies – a review

(2020) Maria Alessia Schouten et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Nanoparticles based on complex of berberine chloride and polymethacrylic or polyacrylic acid with antioxidant and in vitro antitumor activities

(2020) Nikoleta Stoyanova et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Berberine mitigates oxidative damage associated with testicular impairment following mercury chloride intoxication

(2020) Gadah Albasher et al.   JOURNAL OF FOOD BIOCHEMISTRY

Identification of the first noncompetitive SARM1 inhibitors

(2020) Heather S. Loring et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

(2019) Andrea Loreto et al.   NEUROBIOLOGY OF DISEASE

Development and Percutaneous Permeation Study of Escinosomes, Escin-Based Nanovesicles Loaded with Berberine Chloride

(2019) Giulia Vanti et al.   Pharmaceutics

Sulfonato-β-Cyclodextrin Mediated Supramolecular Nanoparticle for Controlled Release of Berberine

(2018) Xu-Man Chen et al.   ACS Applied Materials & Interfaces

Novel cremochylomicrons for improved oral bioavailability of the antineoplastic phytomedicine berberine chloride: Optimization and pharmacokinetics

(2018) Manal A Elsheikh et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioactive-Chylomicrons for Oral Lymphatic Targeting of Berberine Chloride: Novel Flow-Blockage Assay in Tissue-Based and Caco-2 Cell Line Models

(2018) Manal A. Elsheikh et al.   PHARMACEUTICAL RESEARCH

Male germ cells support long-term propagation of Zika virus

(2018) Christopher L. Robinson et al.   Nature Communications

Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy

(2018) Guofei Li et al.   Asian Journal of Pharmaceutical Sciences

Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

(2017) Iris E. Allijn et al.   JOURNAL OF CONTROLLED RELEASE

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Sarm1 Deletion, but Not Wld S , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

(2017) Jonathan Gilley et al.   Cell Reports

Development and Validation of an UPLC-MS/MS Method for Pharmacokinetic Comparison of Five Alkaloids from JinQi Jiangtang Tablets and Its Monarch Drug Coptidis Rhizoma

(2017) Lili Sun et al.   Pharmaceutics

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

(2016) Stefanie Geisler et al.   BRAIN

Delivery system for berberine chloride based on the nanocarrier ZnAl-layered double hydroxide: Physicochemical characterization, release behavior and evaluation of anti-bacterial potential

(2016) Mohamed Amine Djebbi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

The Role of Berberine in the Multi-Target Treatment of Senile Dementia

(2015) Min Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis

(2015) Yan Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The therapeutic potential of Berberine chloride hydrate against harmaline-induced motor impairments in a rat model of tremor

(2015) Zohreh Vaziri et al.   NEUROSCIENCE LETTERS

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats

(2014) Mohamed S. Othman et al.   FOOD AND CHEMICAL TOXICOLOGY

Berberine, an Epiphany Against Cancer

(2014) Luis Guamán Ortiz et al.   MOLECULES

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

(2013) Hitoshi Murata et al.   MOLECULAR BIOLOGY OF THE CELL

Neurotoxicity of Acrylamide in Exposed Workers

(2013) Manuela Pennisi et al.   International Journal of Environmental Research and Public Health

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

(2011) Porkodi Panneerselvam et al.   BIOCHEMICAL JOURNAL

Enhancing effects of chitosan and chitosan hydrochloride on intestinal absorption of berberine in rats

(2011) Wei Chen et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery

(2011) Zhen-Hai Zhang et al.   MOLECULES

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders

(2009) S. K. Kulkarni et al.   PHYTOTHERAPY RESEARCH

SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human

(2007) Loh Wei-Ching Belinda et al.   MOLECULAR IMMUNOLOGY