Mechanisms of organelle elimination for lens development and differentiation

Organelle degradation in the lens by PLAAT phospholipases

(2021) Hideaki Morishita et al.   NATURE

Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish

(2020) Jing Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mechanisms of action of chromatin remodelers and implications in development and disease

(2020) Rakesh Kumar Sahu et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a

(2020) Lisa Brennan et al.   EXPERIMENTAL EYE RESEARCH

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

(2019) Mark A. Lampert et al.   Autophagy

Lens differentiation is characterized by stage-specific changes in chromatin accessibility correlating with differentiation state-specific gene expression

(2019) Joshua Disatham et al.   DEVELOPMENTAL BIOLOGY

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation

(2018) Lisa A. Brennan et al.   EXPERIMENTAL EYE RESEARCH

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

(2018) Saima Limi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues

(2018) Clare Rogerson et al.   Nucleus

Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues

(2018) Clare Rogerson et al.   Nucleus

Nucleosome mobility and the regulation of gene expression: Insights from single-molecule studies

(2017) Sergei Rudnizky et al.   PROTEIN SCIENCE

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

(2016) Shuying He et al.   DEVELOPMENT

Unfolded-protein response–associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract

(2016) Lei Lyu et al.   FASEB JOURNAL

Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells

(2016) M. Joseph Costello et al.   PLoS One

Autophagy in the eye: Development, degeneration, and aging

(2016) Patricia Boya et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX

(2015) Paul A. Ney   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure and organization of chromatin fiber in the nucleus

(2015) Guohong Li et al.   FEBS LETTERS

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells

(2014) Subhasree Basu et al.   Autophagy

Critical roles of DNase1l3l in lens nuclear degeneration in zebrafish

(2014) Atsumi Iida et al.   BIOCHIMIE

Self and Nonself: How Autophagy Targets Mitochondria and Bacteria

(2014) Felix Randow et al.   Cell Host & Microbe

Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly

(2014) B. R. Chaffee et al.   DEVELOPMENT

Preserve the (intraocular) environment: the importance of maintaining normal oxygen gradients in the eye

(2014) David C. Beebe et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

α6 Integrin Transactivates Insulin-like Growth Factor Receptor-1 (IGF-1R) to Regulate Caspase-3-mediated Lens Epithelial Cell Differentiation Initiation

(2014) Subhasree Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differentiation State-Specific Mitochondrial Dynamic Regulatory Networks Are Revealed by Global Transcriptional Analysis of the Developing Chicken Lens

(2014) Daniel Chauss et al.   G3-Genes Genomes Genetics

Autophagy in Development, Cell Differentiation, and Homeodynamics: From Molecular Mechanisms to Diseases and Pathophysiology

(2014) Ioannis P. Nezis et al.   Biomed Research International

HSF4 regulates DLAD expression and promotes lens de-nucleation

(2013) Xiukun Cui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy and mitophagy participate in ocular lens organelle degradation

(2013) M. Joseph Costello et al.   EXPERIMENTAL EYE RESEARCH

Deletion of Autophagy-related 5 (Atg5) andPik3c3Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation

(2013) Hideaki Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

(2012) Ji Zhang et al.   Autophagy

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mutations in FYCO1 Cause Autosomal-Recessive Congenital Cataracts

(2011) Jianjun Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitophagy: A Complex Mechanism of Mitochondrial Removal

(2011) Ivana Novak   ANTIOXIDANTS & REDOX SIGNALING

Normal and disordered reticulocyte maturation

(2011) Paul A Ney   CURRENT OPINION IN HEMATOLOGY

Biological glass: structural determinants of eye lens transparency

(2011) S. Bassnett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lens fibre cell differentiation and organelle loss: many paths lead to clarity

(2011) M. A. Wride   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Autophagy's Top Chef

(2011) A. M. Cuervo   SCIENCE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

p62, an autophagy hero or culprit?

(2010) Tor Erik Rusten et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perturbing the Ubiquitin Pathway Reveals How Mitosis Is Hijacked to Denucleate and Regulate Cell Proliferation and Differentiation In Vivo

(2010) Andrea Caceres et al.   PLoS One

Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

(2010) Shuying He et al.   Epigenetics & Chromatin

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Discovery of Atg5/Atg7-independent alternative macroautophagy

(2009) Yuya Nishida et al.   NATURE

Autophagy takes an alternative route

(2009) Francesca Cesari   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Towards an integrated understanding of the structure and mechanics of the cell nucleus

(2008) Amy C. Rowat et al.   BIOESSAYS

On the mechanism of organelle degradation in the vertebrate lens

(2008) Steven Bassnett   EXPERIMENTAL EYE RESEARCH

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE