Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration

TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress

(2021) Michael L. Risner et al.   Frontiers in Cellular Neuroscience

Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice

(2020) Moises Freitas-Andrade et al.   Biomolecules

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

(2020) Gareth W. Price et al.   Cell Communication and Signaling

Glial connexins and pannexins in the healthy and diseased brain

(2020) Christian BA Giaume et al.   PHYSIOLOGICAL REVIEWS

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

(2020) Ciaran Murphy-Royal et al.   Nature Communications

Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress

(2020) Melissa L. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

Rising Stars: Astrocytes as a Therapeutic Target for ALS Disease

(2020) Michal Izrael et al.   Frontiers in Neuroscience

Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain

(2020) Yujiao Lu et al.   JOURNAL OF NEUROSCIENCE

Astrocytes—The Ultimate Effectors of Long-Range Neuromodulatory Networks?

(2020) Anthony G. Pacholko et al.   Frontiers in Cellular Neuroscience

Connexin43 hemichannel block inhibits NLRP3 inflammasome activation in a human retinal explant model of diabetic retinopathy

(2020) Henry H. Louie et al.   EXPERIMENTAL EYE RESEARCH

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

(2019) Shaimaa Mahmoud et al.   Cells

The Strategic Location of Glycogen and Lactate: From Body Energy Reserve to Brain Plasticity

(2019) Corrado Calì et al.   Frontiers in Cellular Neuroscience

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

(2019) Moises Freitas-Andrade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown

(2019) Charisse Kuo et al.   ACTA DIABETOLOGICA

Inhibition of Cx43 gap junction uncoupling prevents high glucose-induced apoptosis and reduces excess cell monolayer permeability in retinal vascular endothelial cells

(2018) Dongjoon Kim et al.   EXPERIMENTAL EYE RESEARCH

Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice

(2018) Ryan S. Tonkin et al.   EXPERIMENTAL NEUROLOGY

Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus

(2018) José Ek-Vitorín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration

(2018) Mohammad Harun-Or-Rashid et al.   JOURNAL OF NEUROSCIENCE

Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma

(2018) Michael L. Risner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte remodeling without gliosis precedes optic nerve axonopathy

(2018) Melissa L. Cooper et al.   Acta Neuropathologica Communications

Stroke target identification guided by astrocyte transcriptome analysis

(2018) Cordula Rakers et al.   GLIA

Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease

(2018) Odunayo O. Mugisho et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

(2018) Yingzhu Chen et al.   Frontiers in Cellular Neuroscience

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

(2018) Yuji Kajiwara et al.   Acta Neuropathologica Communications

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

(2017) Pradoldej Sompol et al.   JOURNAL OF NEUROSCIENCE

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

(2017) Lotti M. Supplie et al.   JOURNAL OF NEUROSCIENCE

Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex

(2017) Claire Meunier et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

(2017) Yeri Kim et al.   Neurotherapeutics

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target

(2017) Mathieu Charvériat et al.   Frontiers in Cellular Neuroscience

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep

(2017) Robert Galinsky et al.   Scientific Reports

Connexin43 and AMPK Have Essential Role in Resistance to Oxidative Stress Induced Necrosis

(2017) Chunshan Zhao et al.   Biomed Research International

Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats

(2017) Yilin Mao et al.   EXPERIMENTAL BRAIN RESEARCH

The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy

(2017) Andrea Becerra-Calixto et al.   Frontiers in Molecular Neuroscience

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

(2017) Wilson Wong et al.   Nature Microbiology

Cytosolic NADH-NAD+ Redox Visualized in Brain Slices by Two-Photon Fluorescence Lifetime Biosensor Imaging

(2016) Rebecca Mongeon et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotective Role of Gap Junctions in a Neuron Astrocyte Network Model

(2016) Gemma Huguet et al.   BIOPHYSICAL JOURNAL

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma

(2016) Melissa L. Cooper et al.   EXPERIMENTAL EYE RESEARCH

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

(2016) Virginia Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connexin43 in retinal injury and disease

(2016) Helen V. Danesh-Meyer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Glucose Tightly Controls Morphological and Functional Properties of Astrocytes

(2016) Chun-Yao Lee et al.   Frontiers in Aging Neuroscience

Gap junction coupling confers isopotentiality on astrocyte syncytium

(2015) Baofeng Ma et al.   GLIA

Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations

(2015) L. Roux et al.   JOURNAL OF NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling

(2015) Manuel F. Muñoz et al.   Frontiers in Cellular Neuroscience

Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells

(2014) Stephanie Griemsmann et al.   CEREBRAL CORTEX

Mix and match: Investigating heteromeric and heterotypic gap junction channels in model systems and native tissues

(2014) Michael Koval et al.   FEBS LETTERS

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

Reversible reactivity by optic nerve astrocytes

(2013) Daniel Sun et al.   GLIA

Connexin 43 Channels Protect Osteocytes Against Oxidative Stress-Induced Cell Death

(2013) Rekha Kar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury

(2013) Simon J. O’Carroll et al.   NEUROSCIENCE RESEARCH

Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway

(2013) Chih-Kai Liao et al.   PLoS One

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia

(2012) Helen V. Danesh-Meyer et al.   BRAIN

Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices

(2012) P. Jakoby et al.   CEREBRAL CORTEX

Oxidative stress and mitochondrial dysfunction in glaucoma

(2012) Vicki Chrysostomou et al.   CURRENT OPINION IN PHARMACOLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+

(2012) F. Wang et al.   Science Signaling

The metabolic efficiency of myelinated vs unmyelinated axons

(2011) Ali M Neishabouri et al.   BMC NEUROSCIENCE

Pharmacological modulation of connexin-formed channels in cardiac pathophysiology

(2011) Elke De Vuyst et al.   BRITISH JOURNAL OF PHARMACOLOGY

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss

(2011) Nathan M. Kerr et al.   EXPERIMENTAL NEUROLOGY

Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

(2011) Jane Achan et al.   MALARIA JOURNAL

Astroglial networks scale synaptic activity and plasticity

(2011) U. Pannasch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

(2010) John C. Morrison et al.   EXPERIMENTAL EYE RESEARCH

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

(2010) Claude F. Burgoyne   EXPERIMENTAL EYE RESEARCH

Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3

(2010) Chih-Kai Liao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Temporary Focal Cerebral Ischemia Results in Swollen Astrocytic End-Feet That Compress Microvessels and Lead to Focal Cortical Infarction

(2010) Umeo Ito et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Gap junction protein connexin43 (GJA1) in the human glaucomatous optic nerve head and retina

(2010) Nathan M. Kerr et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The Connexin43 C-Terminal Region Mediates Neuroprotection During Stroke

(2010) Michael G. Kozoriz et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury

(2010) Ghayda Hawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effects of Chronic Gap Junction Conduction–Enhancing Antiarrhythmic Peptide GAP-134 Administration on Experimental Atrial Fibrillation in Dogs

(2009) Gabriel Laurent et al.   Circulation-Arrhythmia and Electrophysiology

Direct Actions of Carbenoxolone on Synaptic Transmission and Neuronal Membrane Properties

(2009) Kenneth R. Tovar et al.   JOURNAL OF NEUROPHYSIOLOGY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Interretinal transduction of injury signals after unilateral optic nerve crush

(2009) Tamar Macharadze et al.   NEUROREPORT

Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury

(2008) Simon J. O'Carroll et al.   CELL COMMUNICATION AND ADHESION

Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes

(2008) Annette Koulakoff et al.   GLIA

Connexin43 antisense oligodeoxynucleotide treatment down-regulates the inflammatory response in an in vitro interphase organotypic culture model of optic nerve ischaemia

(2008) Helen V. Danesh-Meyer et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Glial connexins and gap junctions in CNS inflammation and disease

(2008) Tammy Kielian   JOURNAL OF NEUROCHEMISTRY

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

(2008) B. van Zundert et al.   JOURNAL OF NEUROSCIENCE

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE