The ticking of aging clocks

Loss of epigenetic information as a cause of mammalian aging

(2023) Jae-Hyun Yang et al.   CELL

Resurrection of endogenous retroviruses during aging reinforces senescence

(2023) Xiaoqian Liu et al.   CELL

Distinct longevity mechanisms across and within species and their association with aging

(2023) Alexander Tyshkovskiy et al.   CELL

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

(2023) Tzu-Chiao Lu et al.   SCIENCE

Engineering longevity—design of a synthetic gene oscillator to slow cellular aging

(2023) Zhen Zhou et al.   SCIENCE

cGAS–STING drives ageing-related inflammation and neurodegeneration

(2023) Muhammet F. Gulen et al.   NATURE

Human PBMC scRNA-seq–based aging clocks reveal ribosome to inflammation balance as a single-cell aging hallmark and super longevity

(2023) Hongming Zhu et al.   Science Advances

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

(2022) Andrew C. Yang et al.   NATURE

Skin senescence: mechanisms and impact on whole-body aging

(2022) Ana Catarina Franco et al.   TRENDS IN MOLECULAR MEDICINE

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

(2022) Zunpeng Liu et al.   Cell Discovery

Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation

(2022) J. Yuyang Lu et al.   Cell Metabolism

Chemical reprogramming of human somatic cells to pluripotent stem cells

(2022) Jingyang Guan et al.   NATURE

Somatic genomic changes in single Alzheimer’s disease neurons

(2022) Michael B. Miller et al.   NATURE

The longitudinal dynamics and natural history of clonal haematopoiesis

(2022) Margarete A. Fabre et al.   NATURE

Somatic mutation rates scale with lifespan across mammals

(2022) Alex Cagan et al.   NATURE

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

(2022) Róbert Pálovics et al.   NATURE

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

(2022) Zhenqiu Huang et al.   NATURE GENETICS

Measuring biological age using omics data

(2022) Jarod Rutledge et al.   NATURE REVIEWS GENETICS

Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability

(2022) Taejeong Bae et al.   SCIENCE

KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA–DNA triplexes and HP1 binding

(2022) Xiaoli Zhang et al.   NATURE CELL BIOLOGY

Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

(2021) Daryle J. DePianto et al.   JCI Insight

Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

(2021) Kara N. Fitzgerald et al.   Aging-US

A molecular single-cell lung atlas of lethal COVID-19

(2021) Johannes C. Melms et al.   NATURE

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

Single-cell multi-omics analysis of the immune response in COVID-19

(2021) Emily Stephenson et al.   NATURE MEDICINE

Assessing the rate of aging to monitor aging itself

(2021) Xian Xia et al.   AGEING RESEARCH REVIEWS

A Metabolomic Aging Clock Using Human Cerebrospinal Fluid

(2021) Nathan Hwangbo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Virus-induced senescence is driver and therapeutic target in COVID-19

(2021) Soyoung Lee et al.   NATURE

Genetic insights into biological mechanisms governing human ovarian ageing

(2021) Katherine S. Ruth et al.   NATURE

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

(2021) Ines Sturmlechner et al.   SCIENCE

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

(2020) Si Wang et al.   CELL

Personal aging markers and ageotypes revealed by deep longitudinal profiling

(2020) Sara Ahadi et al.   NATURE MEDICINE

An epigenetic clock for human skeletal muscle

(2020) Sarah Voisin et al.   Journal of Cachexia Sarcopenia and Muscle

Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver

(2020) K. Brazhnik et al.   Science Advances

Determinants of accelerated metabolomic and epigenetic aging in a UK cohort

(2020) Oliver Robinson et al.   AGING CELL

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

(2020) Jinwook Choi et al.   Cell Stem Cell

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

(2020) Fedor Galkin et al.   iScience

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

(2020) Benoit Lehallier et al.   AGING CELL

Underlying features of epigenetic aging clocks in vivo and in vitro

(2020) Zuyun Liu et al.   AGING CELL

Plasma proteomic profile of age, health span, and all‐cause mortality in older adults

(2020) Sanish Sathyan et al.   AGING CELL

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16

(2020) Dawei Shi et al.   Nature Communications

Metabolic Age Based on the BBMRI-NL 1 H-NMR Metabolomics Repository as Biomarker of Age-related Disease

(2020) Erik B. van den Akker et al.   Circulation-Genomic and Precision Medicine

PsychoAge and SubjAge: development of deep markers of psychological and subjective age using artificial intelligence

(2020) Alex Zhavoronkov et al.   Aging-US

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Single-Cell Transcriptomic Atlas of Human Skin Aging

(2020) Zhiran Zou et al.   DEVELOPMENTAL CELL

DNA methylation GrimAge strongly predicts lifespan and healthspan

(2019) Ake T. Lu et al.   Aging-US

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

(2019) Polina Mamoshina et al.   Scientific Reports

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

(2019) Lei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation-induced DNA damage, mutations and cancer

(2019) Jennifer Kay et al.   DNA REPAIR

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

(2019) Qian Zhang et al.   Genome Medicine

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production

(2019) Luke S. Tain et al.   AGING CELL

Cardiovascular Disease, Aging, and Clonal Hematopoiesis

(2019) Megan A. Evans et al.   Annual Review of Pathology-Mechanisms of Disease

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

An epigenetic biomarker of aging for lifespan and healthspan

(2018) Morgan E. Levine et al.   Aging-US

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

Population Specific Biomarkers of Human Aging: A Big Data Study Using South Korean, Canadian, and Eastern European Patient Populations

(2018) Polina Mamoshina et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metabolic and inflammatory biomarkers are associated with epigenetic aging acceleration estimates in the GOLDN study

(2018) Marguerite R. Irvin et al.   Clinical Epigenetics

Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification

(2018) Polina Mamoshina et al.   Frontiers in Genetics

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

(2018) Steve Horvath et al.   Aging-US

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

(2018) Nelly Olova et al.   AGING CELL

PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging

(2018) Eugene Bobrov et al.   Aging-US

Predicting brain-age from multimodal imaging data captures cognitive impairment

(2017) Franziskus Liem et al.   NEUROIMAGE

Predicting Age Using Neuroimaging: Innovative Brain Ageing Biomarkers

(2017) James H. Cole et al.   TRENDS IN NEUROSCIENCES

Inference of differentiation time for single cell transcriptomes using cell population reference data

(2017) Na Sun et al.   Nature Communications

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

(2017) Yan Zhang et al.   Nature Communications

Caloric restriction delays age-related methylation drift

(2017) Shinji Maegawa et al.   Nature Communications

DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

(2016) Qiong Lin et al.   Aging-US

A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

(2016) Lei Hou et al.   Cell Metabolism

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

(2016) Laura Perna et al.   Clinical Epigenetics

Blood Epigenetic Age may Predict Cancer Incidence and Mortality

(2016) Yinan Zheng et al.   EBioMedicine

DNA methylation age is associated with mortality in a longitudinal Danish twin study

(2015) Lene Christiansen et al.   AGING CELL

The rate of aging: the rate of deficit accumulation does not change over the adult life span

(2015) Arnold Mitnitski et al.   BIOGERONTOLOGY

Three-dimensional human facial morphologies as robust aging markers

(2015) Weiyang Chen et al.   CELL RESEARCH

Measuring Biological Age via Metabonomics: The Metabolic Age Score

(2015) Johannes Hertel et al.   JOURNAL OF PROTEOME RESEARCH

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

Glycans Are a Novel Biomarker of Chronological and Biological Ages

(2013) Jasminka Krištić et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One