Regulatory T cells in allergic inflammation

Regulatory T-cells in asthma

(2023) Hani Harb et al.   Current Opinion in Allergy and Clinical Immunology

Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6

(2023) Safa Baris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A common IL‐4 receptor variant promotes asthma severity via a T reg cell GRB2‐IL‐6‐Notch4 circuit

(2022) Mehdi Benamar et al.   ALLERGY

Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells

(2022) Joris van der Veeken et al.   IMMUNITY

Regulation of the IgE Response by T Follicular Regulatory Cells

(2022) Qiang Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T cells in skeletal muscle repair and regeneration: recent insights

(2022) Jianhui Wu et al.   Cell Death & Disease

Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2

(2022) Qiang Chen et al.   Cell Reports

A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

(2022) Ranit Kedmi et al.   NATURE

ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

(2022) Mengze Lyu et al.   NATURE

Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota

(2022) Blossom Akagbosu et al.   NATURE

Regulatory T cells as metabolic sensors

(2022) Paola de Candia et al.   IMMUNITY

An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance

(2022) Emmanuel Stephen-Victor et al.   IMMUNITY

Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells

(2022) Katherine A. Kaiser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Food allergy as a biological food quality control system

(2021) Esther B. Florsheim et al.   CELL

Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy

(2021) Lila T. Yokanovich et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The basic immunology of asthma

(2021) Hamida Hammad et al.   CELL

Essential functions of regulatory T cell TGF-β1 revealed by differential gene-targeting approaches

(2021) Emmanuel Stephen-Victor et al.   IMMUNITY

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

(2021) Hani Harb et al.   IMMUNITY

Atopic Dermatitis

(2021) Sonja Ständer   NEW ENGLAND JOURNAL OF MEDICINE

Loss of regulatory capacity in Treg cells following rhinovirus infection

(2021) Kirstin Jansen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cellular and molecular mechanisms of allergic asthma

(2021) Zsolt I. Komlósi et al.   MOLECULAR ASPECTS OF MEDICINE

Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro

(2021) Mónica Martínez-Blanco et al.   Frontiers in Immunology

Reduced CCR6+IL-17A+Treg Cells in Blood and CCR6-Dependent Accumulation of IL-17A+Treg Cells in Lungs of Patients With Allergic Asthma

(2021) Xiaokun Shen et al.   Frontiers in Immunology

The Role of CD4+ T Cells and Microbiota in the Pathogenesis of Asthma

(2021) Jiung Jeong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

γδT17/γδTreg cell subsets: a new paradigm for asthma treatment

(2021) Yi-En Yao et al.   JOURNAL OF ASTHMA

Primary Atopic Disorders

(2020) Joshua D. Milner   Annual Review of Immunology

Regulation of IgE by T follicular helper cells

(2020) Uthaman Gowthaman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Type 2 immunity in the skin and lungs

(2020) Cezmi A. Akdis et al.   ALLERGY

Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair

(2020) Ian C. Boothby et al.   Science Immunology

Therapeutic Potential of the Intestinal Microbiota for Immunomodulation of Food Allergies

(2020) Luisa Kreft et al.   Frontiers in Immunology

Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy

(2020) Yin Yao et al.   ALLERGY

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation

(2020) Amrita Banerjee et al.   GASTROENTEROLOGY

Dietary and Microbial Determinants in Food Allergy

(2020) Emmanuel Stephen-Victor et al.   IMMUNITY

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

(2020) Jacob A. Turner et al.   IMMUNITY

Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung

(2020) Lucas D. Faustino et al.   NATURE IMMUNOLOGY

A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma

(2020) Hani Harb et al.   NATURE IMMUNOLOGY

The microbial origins of food allergy

(2020) Rima Rachid et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint

(2020) Mohammad Afzal Khan   Journal of Translational Medicine

Insights into atopic dermatitis gained from genetically defined mouse models

(2019) Saeko Nakajima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Healthy infants harbor intestinal bacteria that protect against food allergy

(2019) Taylor Feehley et al.   NATURE MEDICINE

A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult

(2019) Ziad Al Nabhani et al.   IMMUNITY

Thinking bigger: How early‐life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease

(2019) Hind Sbihi et al.   ALLERGY

Epithelial cell–derived cytokines: more than just signaling the alarm

(2019) Florence Roan et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

(2019) Lei Zhou et al.   NATURE

Impact of High Altitude Therapy on Type‐2 Immune Responses in Asthma Patients

(2019) Tadech Boonpiyathad et al.   ALLERGY

Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy

(2019) Azza Abdel-Gadir et al.   NATURE MEDICINE

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

Functional reprogramming of regulatory T cells in the absence of Foxp3

(2019) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

(2019) Rachel L. Clement et al.   NATURE IMMUNOLOGY

Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses

(2019) Lokesh A. Kalekar et al.   Science Immunology

Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

(2019) Clarissa Campbell et al.   Cell Metabolism

Il-10 producing T and B cells in allergy

(2019) Tadech Boonpiyathad et al.   SEMINARS IN IMMUNOLOGY

Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function

(2018) A. Abdel-Gadir et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Der p 1-specific regulatory T-cell response during house dust mite allergen immunotherapy

(2018) Tadech Boonpiyathad et al.   ALLERGY

The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

(2018) Teruki Dainichi et al.   NATURE IMMUNOLOGY

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

(2018) Oliver J. Harrison et al.   SCIENCE

Immunology of Food Allergy

(2017) Leticia Tordesillas et al.   IMMUNITY

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

(2017) Oscar Palomares et al.   IMMUNOLOGICAL REVIEWS

IL-25 in allergic inflammation

(2017) Miao Xu et al.   IMMUNOLOGICAL REVIEWS

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs

(2017) Chien-Chang Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of viral infections in the development and exacerbation of asthma in children

(2017) Tuomas Jartti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

(2017) Victoria S. Pelly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis

(2017) Allyson L. Byrd et al.   Science Translational Medicine

Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses

(2017) Xinyue Hu et al.   Scientific Reports

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function

(2016) Magali Noval Rivas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T cells in allergic diseases

(2016) Magali Noval Rivas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells

(2016) Amir Hossein Massoud et al.   NATURE MEDICINE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism

(2015) Sen Wang et al.   IMMUNITY

Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy

(2015) Magali Noval Rivas et al.   IMMUNITY

The allergy epidemics: 1870-2010

(2015) Thomas A.E. Platts-Mills   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

(2015) B-H Yang et al.   Mucosal Immunology

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

(2014) Aleena Syed et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Memory regulatory T cells reside in human skin

(2014) Robert Sanchez Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ regulatory T cells promote lung epithelial proliferation

(2014) J R Mock et al.   Mucosal Immunology

Allergic Inflammation—Innately Homeostatic

(2014) Laurence E. Cheng et al.   Cold Spring Harbor Perspectives in Biology

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice

(2013) L. R. Durant et al.   JOURNAL OF VIROLOGY

Asthma

(2013) Fernando D Martinez et al.   LANCET

Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma

(2013) Minal Çalışkan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation and Function of Induced Regulatory T Cells

(2013) Erica G. Schmitt et al.   Frontiers in Immunology

Regulatory T Cells Reduce Acute Lung Injury Fibroproliferation by Decreasing Fibrocyte Recruitment

(2012) Brian T. Garibaldi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Foxp3+ Cells Control Th2 Responses in a Murine Model of Atopic Dermatitis

(2012) Nanna Fyhrquist et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Allergic host defences

(2012) Noah W. Palm et al.   NATURE

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

(2012) Nandini Krishnamoorthy et al.   NATURE MEDICINE

Treg Cells, Life History, and Diversity

(2012) C. Benoist et al.   Cold Spring Harbor Perspectives in Biology

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Harnessing Regulatory T cells to Suppress Asthma

(2010) Alison N. Thorburn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis

(2010) Yasunori Ito et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

(2009) Raffi Tachdjian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome

(2008) M. Halabi-Tawil et al.   BRITISH JOURNAL OF DERMATOLOGY

Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target

(2008) Dorothy K. Sojka et al.   IMMUNOLOGY

Analysis of CD25hiCD4+ “regulatory” T-cell subtypes in atopic dermatitis reveals a novel TH2-like population

(2008) Amanda J. Reefer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The development of allergic inflammation

(2008) Stephen J. Galli et al.   NATURE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology