Epithelial cell–derived cytokines: more than just signaling the alarm

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation

(2018) Miao Xu et al.   IMMUNITY

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

(2018) Timotheus Y.F. Halim et al.   IMMUNITY

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis

(2018) Yuki Morimoto et al.   IMMUNITY

Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps

(2018) Michael A. Kohanski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-25 enhances T H 17 cell–mediated contact dermatitis by promoting IL-1β production by dermal dendritic cells

(2018) Hajime Suto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci

(2018) Lisa J. Martin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin

(2018) Sucai Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33

(2018) Corinne Cayrol et al.   NATURE IMMUNOLOGY

Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility

(2018) Abigail E. Russi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TSLP signaling in CD4+T cells programs a pathogenic T helper 2 cell state

(2018) Yrina Rochman et al.   Science Signaling

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

(2018) Danielle M. Clancy et al.   Cell Reports

TSLP signaling in CD4+T cells programs a pathogenic T helper 2 cell state

(2018) Yrina Rochman et al.   Science Signaling

A network map of IL-33 signaling pathway

(2018) Sneha M. Pinto et al.   Journal of Cell Communication and Signaling

Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

(2018) Nathan K. Archer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 Upregulates Cysteinyl Leukotriene Receptor Type 1 Expression in Human Peripheral Blood CD4+ T Lymphocytes

(2018) Marie Boudaud et al.   JOURNAL OF IMMUNOLOGY

Tissue signals imprint ILC2 identity with anticipatory function

(2018) Roberto R. Ricardo-Gonzalez et al.   NATURE IMMUNOLOGY

Chromatin regulates IL-33 release and extracellular cytokine activity

(2018) Jared Travers et al.   Nature Communications

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

(2018) Merav Cohen et al.   CELL

CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth

(2018) Kazushige Obata-Ninomiya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

(2018) Takeshi Yamamoto et al.   Nature Communications

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

(2017) Carlos M. Minutti et al.   IMMUNITY

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

(2017) Chikako Shimokawa et al.   IMMUNITY

IL-25 in allergic inflammation

(2017) Miao Xu et al.   IMMUNOLOGICAL REVIEWS

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

(2017) Corinne Cayrol et al.   IMMUNOLOGICAL REVIEWS

Neonatal hyperoxia promotes asthma-like features through IL-33–dependent ILC2 responses

(2017) In Su Cheon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin–driven IL-9 + and IL-13 + type 2 innate lymphoid cell subpopulations

(2017) Mukesh Verma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge

(2017) Sunil K. Ahuja et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cell activation in the neonatal lung drives type 2 immunity and allergen sensitization

(2017) Catherine A. Steer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand interaction

(2017) Diamanda Rigas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proprotein convertases generate a highly functional heterodimeric form of thymic stromal lymphopoietin in humans

(2017) Julie A. Poposki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow

(2017) Matthew T. Stier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control

(2017) Christian Schwartz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 2 Cysteinyl Leukotriene Receptors Drive IL-33–Dependent Type 2 Immunopathology and Aspirin Sensitivity

(2017) Tao Liu et al.   JOURNAL OF IMMUNOLOGY

TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine

(2017) A Pascual-Reguant et al.   Mucosal Immunology

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders

(2017) Erik Wambre et al.   Science Translational Medicine

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment

(2017) Simona Saluzzo et al.   Cell Reports

A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma

(2017) Dirk Smith et al.   PLoS Genetics

Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen-specific modulation of immune reactivity

(2016) D. Hinz et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung

(2016) Ismé M. de Kleer et al.   IMMUNITY

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

(2016) Matthew T. Stier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function

(2016) Alyssa Mitson-Salazar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Platelets constitutively express IL-33 protein and modulate eosinophilic airway inflammation

(2016) Tomohiro Takeda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen

(2016) A Sheih et al.   Mucosal Immunology

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

A tissue checkpoint regulates type 2 immunity

(2016) Steven J Van Dyken et al.   NATURE IMMUNOLOGY

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy

(2016) Boyi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative splicing of interleukin-33 and type 2 inflammation in asthma

(2016) Erin D. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease

(2015) Paolo Biancheri et al.   GUT

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

(2015) Hideaki Morita et al.   IMMUNITY

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

(2015) Yusuke Endo et al.   IMMUNITY

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis

(2015) Hyun-Woo Shin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin signaling in CD4+ T cells is required for TH2 memory

(2015) Qun Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dichotomy of short and long thymic stromal lymphopoietin isoforms in inflammatory disorders of the bowel and skin

(2015) Giulia Fornasa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses

(2015) Claudia Baumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33

(2015) Wei-Yu Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of TSLP in allergic disease and its role as a potential therapeutic target

(2014) Antonella Cianferoni et al.   Expert Review of Clinical Immunology

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy

(2014) T. Muto et al.   INTERNATIONAL IMMUNOLOGY

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

(2014) Mario Noti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association of IL33–IL-1 receptor–like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood

(2014) Olga E. Savenije et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

Expression and Cellular Provenance of Thymic Stromal Lymphopoietin and Chemokines in Patients with Severe Asthma and Chronic Obstructive Pulmonary Disease

(2014) S. Ying et al.   JOURNAL OF IMMUNOLOGY

Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

(2014) E. A. Rickel et al.   JOURNAL OF IMMUNOLOGY

The Critical Role of Epithelial-Derived Act1 in IL-17- and IL-25-Mediated Pulmonary Inflammation

(2014) S. Swaidani et al.   JOURNAL OF IMMUNOLOGY

The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation

(2014) E. Claudio et al.   JOURNAL OF IMMUNOLOGY

GM-CSF–Licensed CD11b+Lung Dendritic Cells Orchestrate Th2 Immunity toBlomia tropicalis

(2014) Qian Zhou et al.   JOURNAL OF IMMUNOLOGY

CD326loCD103loCD11bloDermal Dendritic Cells Are Activated by Thymic Stromal Lymphopoietin during Contact Sensitization in Mice

(2014) Sotaro Ochiai et al.   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

(2014) Leah C Kottyan et al.   NATURE GENETICS

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells

(2014) Yuefeng Huang et al.   NATURE IMMUNOLOGY

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

(2014) Gail M. Gauvreau et al.   NEW ENGLAND JOURNAL OF MEDICINE

A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

(2014) Alba Llop-Guevara et al.   PLoS One

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP

(2013) Weiguo Yao et al.   IMMUNITY

Decoding asthma: Translating genetic variation in IL33 and IL1RL1 into disease pathophysiology

(2013) Néomi S. Grotenboer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells

(2013) Steven A. Saenz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Identification of the Thymic Stromal Lymphopoietin-Responsive Dendritic Cell Subset Critical for Initiation of Type 2 Contact Hypersensitivity

(2013) M. Kitajima et al.   JOURNAL OF IMMUNOLOGY

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

(2013) I Mosconi et al.   Mucosal Immunology

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

(2013) Klaus Bønnelykke et al.   NATURE GENETICS

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

(2013) Bryan D Bell et al.   NATURE IMMUNOLOGY

Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis

(2013) Mario Noti et al.   NATURE MEDICINE

Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

(2013) Yasutomo Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

(2013) Hiroki Kabata et al.   Nature Communications

IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation

(2012) Clare S. Hardman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation

(2012) Yanlu Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand

(2012) Junyan Han et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells

(2012) Rahul Kakkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

Novel Splice Variants of IL-33: Differential Expression in Normal and Transformed Cells

(2012) Hidetoshi Tsuda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-33 and ST2 in Atopic Dermatitis: Expression Profiles and Modulation by Triggering Factors

(2012) Terhi Savinko et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of IL-33 Expression by IFN-γ and Tumor Necrosis Factor-α in Normal Human Epidermal Keratinocytes

(2012) Jitlada Meephansan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond

(2012) Florence Roan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology

(2012) Bryan C Petersen et al.   NATURE MEDICINE

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

(2012) Adaikalavan Ramasamy et al.   PLoS One

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

IL-25 drives remodelling in allergic airways disease induced by house dust mite

(2012) Lisa G Gregory et al.   THORAX

TSLP enhances the function of helper type 2 cells

(2011) Masayuki Kitajima et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymic Stromal Lymphopoetin-Induced Expression of the Endogenous Inhibitory Enzyme SLPI Mediates Recovery from Colonic Inflammation

(2011) Colin Reardon et al.   IMMUNITY

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

(2011) Chris J. Corrigan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of Constitutively Active Interleukin 33 (IL-33) Splice Variant

(2011) Jaewoo Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells

(2011) M. Kashyap et al.   JOURNAL OF IMMUNOLOGY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF- B To Dampen NF- B-Stimulated Gene Transcription

(2011) S. Ali et al.   JOURNAL OF IMMUNOLOGY

TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

(2011) Mark C. Siracusa et al.   NATURE

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

The Human Airway Epithelial Basal Cell Transcriptome

(2011) Neil R. Hackett et al.   PLoS One

T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma

(2011) C. J. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased IL-33 expression by epithelial cells in bronchial asthma

(2010) David Préfontaine et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells

(2010) A. Yagami et al.   JOURNAL OF IMMUNOLOGY

Thymic Stromal Lymphopoietin-Activated Plasmacytoid Dendritic Cells Induce the Generation of FOXP3+ Regulatory T Cells in Human Thymus

(2010) S. Hanabuchi et al.   JOURNAL OF IMMUNOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses

(2010) Steven A. Saenz et al.   NATURE

Regulation of IL-9 expression by IL-25 signaling

(2010) Pornpimon Angkasekwinai et al.   NATURE IMMUNOLOGY

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TSLP and IL-7 use two different mechanisms to regulate human CD4+T cell homeostasis

(2009) Ning Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells

(2009) D. Prefontaine et al.   JOURNAL OF IMMUNOLOGY

Induction of Airway Hyperreactivity by IL-25 Is Dependent on a Subset of Invariant NKT Cells Expressing IL-17RB

(2009) P. Stock et al.   JOURNAL OF IMMUNOLOGY

Pulmonary IL-17E (IL-25) Production and IL-17RB+ Myeloid Cell-Derived Th2 Cytokine Production Are Dependent upon Stem Cell Factor-Induced Responses during Chronic Allergic Pulmonary Disease

(2009) V. Dolgachev et al.   JOURNAL OF IMMUNOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma

(2009) Sangeeta Goswami et al.   NATURE IMMUNOLOGY

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33

(2008) T. Pecaric-Petkovic et al.   BLOOD

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

(2008) Colby Zaph et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

TSLP acts on infiltrating effector T cells to drive allergic skin inflammation

(2008) R. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA