Thinking bigger: How early‐life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease

Commensal Koch's postulates: establishing causation in human microbiota research

(2018) B Anne Neville et al.   CURRENT OPINION IN MICROBIOLOGY

The Urban Exposome during Pregnancy and Its Socioeconomic Determinants

(2018) Oliver Robinson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study

(2018) Christina Tischer et al.   ENVIRONMENTAL RESEARCH

Dog introduction alters the home dust microbiota

(2018) A. R. Sitarik et al.   INDOOR AIR

Asthmatic/wheezing phenotypes in preschool children: Influential factors, health care and urban-rural differences

(2018) Susanne Kutzora et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

External exposome and allergic respiratory and skin diseases

(2018) Lorenzo Cecchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

After asthma: redefining airways diseases

(2018) Ian D Pavord et al.   LANCET

Current understanding of the human microbiome

(2018) Jack A Gilbert et al.   NATURE MEDICINE

The role of the indoor environment: Residential determinants of allergy, asthma and pulmonary function in children from a US-Mexico border community

(2018) Erik R. Svendsen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Urbanization Reduces Transfer of Diverse Environmental Microbiota Indoors

(2018) Anirudra Parajuli et al.   Frontiers in Microbiology

Microbiome and Allergic Diseases

(2018) Mariona Pascal et al.   Frontiers in Immunology

Microbial Eukaryotes: a Missing Link in Gut Microbiome Studies

(2018) Isabelle Laforest-Lapointe et al.   mSystems

Microbiome: Focus on Causation and Mechanism

(2018) Michael A. Fischbach   CELL

Could baby’s first bacteria take root before birth?

(2018) Cassandra Willyard   NATURE

Microbiology of the built environment

(2018) Jack A. Gilbert et al.   NATURE REVIEWS MICROBIOLOGY

Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

(2018) Inés Martínez et al.   eLife

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Pet-keeping in early life reduces the risk of allergy in a dose-dependent fashion

(2018) Bill Hesselmar et al.   PLoS One

Factors Shaping the Human Exposome in the Built Environment: Opportunities for Engineering Control

(2017) Dongjuan Dai et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Urban green and grey space in relation to respiratory health in children

(2017) Christina Tischer et al.   EUROPEAN RESPIRATORY JOURNAL

Biodiversity in the city: key challenges for urban green space management

(2017) Myla FJ Aronson et al.   FRONTIERS IN ECOLOGY AND THE ENVIRONMENT

Exploring the associations between parent-reported biological indoor environment and airway-related symptoms and allergic diseases in children

(2017) Alisa Weber et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Where less may be more: how the rare biosphere pulls ecosystems strings

(2017) Alexandre Jousset et al.   ISME Journal

Lessons learned from birth cohort studies conducted in diverse environments

(2017) Daniel J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management

(2017) Diane R. Gold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Environmental determinants of allergy and asthma in early life

(2017) Allison J. Burbank et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

(2017) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sensitization to dust mite defines different phenotypes of asthma: A multicenter study

(2017) Silvia Ruggieri et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Indoor fungal diversity in primary schools may differently influence allergic sensitization and asthma in children

(2017) João Cavaleiro Rufo et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Urban habitat restoration provides a human health benefit through microbiome rewilding: the Microbiome Rewilding Hypothesis

(2017) Jacob G. Mills et al.   RESTORATION ECOLOGY

The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases

(2017) Christine C. Johnson et al.   Translational Research

Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma

(2017) Isabel Halnes et al.   Nutrients

Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention

(2017) Christina E. West et al.   ALLERGOLOGY INTERNATIONAL

Development of the gut microbiota in infancy and its impact on health in later life

(2017) Masaru Tanaka et al.   ALLERGOLOGY INTERNATIONAL

Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

(2017) Dagbjort H. Petursdottir et al.   Frontiers in Immunology

Antibiotic Use in Early Life, Rural Residence, and Allergic Diseases in Argentinean Children

(2017) Yueh-Ying Han et al.   Journal of Allergy and Clinical Immunology-In Practice

From Farming to Engineering: The Microbiota and Allergic Diseases

(2017) Dominique Angèle Vuitton et al.   Engineering

Repercussions of preterm birth on symptoms of asthma, allergic diseases and pulmonary function, 6–14 years later

(2016) C. Gonçalves et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts

(2016) E. Fuertes et al.   ALLERGY

Hygiene factors associated with childhood food allergy and asthma

(2016) Ruchi S. Gupta et al.   ALLERGY AND ASTHMA PROCEEDINGS

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Planting the seed: Origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota

(2016) Lisa F. Stinson et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Fungal Exposure and Asthma: IgE and Non-IgE-Mediated Mechanisms

(2016) Zhonghua Zhang et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier

(2016) Hermelijn H Smits et al.   CURRENT OPINION IN IMMUNOLOGY

The Importance of the Biological Impact of Exposure to the Concept of the Exposome

(2016) Kristine K. Dennis et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Home environment, lifestyles behaviors, and rhinitis in childhood

(2016) Xueying Wang et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children

(2016) Karen C. Dannemiller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

(2016) Kei E Fujimura et al.   NATURE MEDICINE

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

(2016) Michelle M. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of urban particle numbers and sources with lung function among children with asthma or allergies

(2016) Ya-Ru Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective

(2016) Susan Prescott et al.   International Journal of Environmental Research and Public Health

Making microbiology of the built environment relevant to design

(2016) G. Z. Brown et al.   Microbiome

The roles of the outdoors and occupants in contributing to a potential pan-microbiome of the built environment: a review

(2016) Marcus H. Y. Leung et al.   Microbiome

What Have We Learned about the Microbiomes of Indoor Environments?: TABLE 1 

(2016) Brent Stephens   mSystems

Pollen-Associated Microbiome Correlates with Pollution Parameters and the Allergenicity of Pollen

(2016) Andrea Obersteiner et al.   PLoS One

Green areas around homes reduce atopic sensitization in children

(2015) L. Ruokolainen et al.   ALLERGY

Mold allergy revisited

(2015) Jay M. Portnoy et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Having older siblings is associated with gut microbiota development during early childhood

(2015) Martin Frederik Laursen et al.   BMC MICROBIOLOGY

Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy

(2015) D. E. Campbell et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Hunt for the origin of allergy - comparing the Finnish and Russian Karelia

(2015) T. Haahtela et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A review on the human health impact of airborne particulate matter

(2015) Ki-Hyun Kim et al.   ENVIRONMENT INTERNATIONAL

Respiratory allergy caused by house dust mites: What do we really know?

(2015) Moisés A. Calderón et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Indoor fungal diversity and asthma: A meta-analysis and systematic review of risk factors

(2015) Richard A. Sharpe et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Promising candidates for allergy prevention

(2015) James E. Gern   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The microbiome in asthma

(2015) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systems biology of asthma and allergic diseases: A multiscale approach

(2015) Supinda Bunyavanich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Children’s Health and Indoor Air Quality in Primary Schools and Homes in Portugal—Study Design

(2015) Joana Madureira et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

Gut microbiota and aging

(2015) P. W. OToole et al.   SCIENCE

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Our interface with the built environment: immunity and the indoor microbiota

(2015) Simon Lax et al.   TRENDS IN IMMUNOLOGY

Impact of Early-Life Exposures on Immune Maturation and Susceptibility to Disease

(2015) Eva S. Gollwitzer et al.   TRENDS IN IMMUNOLOGY

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

(2015) Seth R. Bordenstein et al.   PLOS BIOLOGY

Early Exposure to Dogs and Farm Animals and the Risk of Childhood Asthma

(2015) Tove Fall et al.   JAMA Pediatrics

The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies

(2014) G. Bowatte et al.   ALLERGY

The Human Early-Life Exposome (HELIX): Project Rationale and Design

(2014) Martine Vrijheid et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation

(2014) J. L. Johnson et al.   GLYCOBIOLOGY

Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children

(2014) Susan V. Lynch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Greenness and allergies: evidence of differential associations in two areas in Germany

(2014) Elaine Fuertes et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter

(2014) Corryn Greenwood et al.   JOURNAL OF PEDIATRICS

Outdoor air pollution and asthma

(2014) Michael Guarnieri et al.   LANCET

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Exposure to house dust phthalates in relation to asthma and allergies in both children and adults

(2014) Yu Ait Bamai et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The Placenta Harbors a Unique Microbiome

(2014) K. Aagaard et al.   Science Translational Medicine

The Intestinal Microbiome in Early Life: Health and Disease

(2014) Marie-Claire Arrieta et al.   Frontiers in Immunology

Allergic sensitization: screening methods

(2014) Gregory S Ladics et al.   Clinical and Translational Allergy

Urban Tree Canopy and Asthma, Wheeze, Rhinitis, and Allergic Sensitization to Tree Pollen in a New York City Birth Cohort

(2013) Gina S. Lovasi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development

(2013) K. C. Dannemiller et al.   INDOOR AIR

Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population

(2013) Yueh-Hsiu Mathilda Chiu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early life exposure to antibiotics and the risk of childhood allergic diseases: An update from the perspective of the hygiene hypothesis

(2013) Chang-Hung Kuo et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

(2013) K. E. Fujimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

(2013) G. A. Rook   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Early-life residential exposure to soil components in rural areas and childhood respiratory health and allergy

(2013) Graham Devereux et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Studying the microbiology of the indoor environment

(2013) Scott T Kelley et al.   GENOME BIOLOGY

Persistent pollen exposure during infancy is associated with increased risk of subsequent childhood asthma and hayfever

(2012) B. Erbas et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Malassezia Genus in Skin and Systemic Diseases

(2012) G. Gaitanis et al.   CLINICAL MICROBIOLOGY REVIEWS

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

(2012) Shannon L Russell et al.   EMBO REPORTS

Amish children living in northern Indiana have a very low prevalence of allergic sensitization

(2012) Mark Holbreich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Use of Antibiotics during Pregnancy Increases the Risk of Asthma in Early Childhood

(2012) Lone Graff Stensballe et al.   JOURNAL OF PEDIATRICS

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

(2012) Atsuko Araki et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative

(2011) C. G. Tischer et al.   ALLERGY

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

(2011) Tina Herbst et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A GIS-Based Assessment of Environmental Influences on Allergy Development in Children

(2011) Agnes Lam et al.   Asia-Pacific Journal of Public Health

Respiratory and Allergic Health Effects of Dampness, Mold, and Dampness-Related Agents: A Review of the Epidemiologic Evidence

(2011) Mark J. Mendell et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Rising prevalence of asthma is sex-specific in a US farming population

(2011) Caroline A. Motika et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age

(2011) Hans Bisgaard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy

(2011) Frederika A. van Nimwegen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of the skin fungal microbiota in patients with atopic dermatitis and in healthy subjects

(2011) Enshi Zhang et al.   MICROBIOLOGY AND IMMUNOLOGY

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Bayesian community-wide culture-independent microbial source tracking

(2011) Dan Knights et al.   NATURE METHODS

Exposure to Environmental Microorganisms and Childhood Asthma

(2011) Markus J. Ege et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Development of gut microbiota in infants not exposed to medical interventions

(2010) MERETE EGGESBø et al.   APMIS

Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 years

(2010) S. Dom et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

Man's best friend? The effect of pet ownership on house dust microbial communities

(2010) Kei E. Fujimura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered early infant gut microbiota in children developing allergy up to 5 years of age

(2009) Y. M. Sjögren et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Living on a Farm: Impact on Asthma Induction and Clinical Course

(2008) Erika von Mutius et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: A systematic review

(2008) Jennifer Koplin et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY