Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2

Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells

(2022) Chen-Hao Yeh et al.   IMMUNITY

Follicular regulatory T cells produce neuritin to regulate B cells

(2021) Paula Gonzalez-Figueroa et al.   CELL

Intrinsic and extrinsic regulation of IgE B cell responses

(2021) Adam K. Wade-Vallance et al.   CURRENT OPINION IN IMMUNOLOGY

Chronic calcium signaling in IgE+ B cells limits plasma cell differentiation and survival

(2021) Rebecca Newman et al.   IMMUNITY

IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells

(2020) Zhiyong Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation

(2020) Byunghee Koh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization

(2020) Biyan Zhang et al.   Science Immunology

T follicular regulatory cells and IL-10 promote food antigen–specific IgE

(2020) Markus M. Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Biology and dynamics of B cells in the context of IgE‐mediated food allergy

(2020) Pattraporn Satitsuksanoa et al.   ALLERGY

T FH cells in bystander and cognate interactions with B cells

(2019) Zurong Wan et al.   IMMUNOLOGICAL REVIEWS

Class-Switch Recombination Occurs Infrequently in Germinal Centers

(2019) Jonathan A. Roco et al.   IMMUNITY

Identification of a T follicular helper cell subset that drives anaphylactic IgE

(2019) Uthaman Gowthaman et al.   SCIENCE

Non-classical B Cell Memory of Allergic IgE Responses

(2019) Sean P. Saunders et al.   Frontiers in Immunology

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

(2019) Rachel L. Clement et al.   NATURE IMMUNOLOGY

IgG1+ B cell immunity predates IgE responses in epicutaneous sensitization to foods

(2018) Rodrigo Jiménez-Saiz et al.   ALLERGY

The IgE memory reservoir in food allergy

(2018) Rodrigo Jiménez-Saiz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells

(2018) Paul-Gydeon Ritvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peanut allergen–specific antibodies go public

(2018) Hannah J. Gould et al.   SCIENCE

Immunology of Food Allergy

(2017) Leticia Tordesillas et al.   IMMUNITY

Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

(2017) Joseph J. Dolence et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Follicular helper T cells mediate IgE antibody response to airborne allergens

(2017) Takao Kobayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T Follicular Helper Cell–Derived IL-4 Is Required for IgE Production during Intestinal Helminth Infection

(2017) Alexandre P. Meli et al.   JOURNAL OF IMMUNOLOGY

IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice

(2017) Marcus J. Robinson et al.   JOURNAL OF IMMUNOLOGY

IgG1 memory B cells keep the memory of IgE responses

(2017) Jin-Shu He et al.   Nature Communications

Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice

(2016) A. Noble et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

(2016) Hao Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite

(2016) André Ballesteros-Tato et al.   IMMUNITY

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

(2016) Yee Ling Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autonomous membrane IgE signaling prevents IgE-memory formation

(2016) Kei Haniuda et al.   NATURE IMMUNOLOGY

Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation

(2016) Xin-guang Liu et al.   Oncotarget

IgE responses in mouse and man and the persistence of IgE memory

(2015) Hannah J. Gould et al.   TRENDS IN IMMUNOLOGY

The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo

(2015) Adriana Turqueti-Neves et al.   PLOS BIOLOGY

Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice

(2015) Junhua Wang et al.   PLoS Neglected Tropical Diseases

Regulatory constraints in the generation and differentiation of IgE-expressing B cells

(2014) Zhiyong Yang et al.   CURRENT OPINION IN IMMUNOLOGY

The distinctive germinal center phase of IgE + B lymphocytes limits their contribution to the classical memory response

(2013) Jin-Shu He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insights into the Role of Bcl6 in Follicular Th Cells Using a New Conditional Mutant Mouse Model

(2013) K. Hollister et al.   JOURNAL OF IMMUNOLOGY

T Follicular Helper Cell Dynamics in Germinal Centers

(2013) Z. Shulman et al.   SCIENCE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

(2012) Zhiyong Yang et al.   IMMUNITY

Sequential class switching is required for the generation of high affinity IgE antibodies

(2012) Huizhong Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IgE+ memory B cells and plasma cells generated through a germinal-center pathway

(2012) Oezcan Talay et al.   NATURE IMMUNOLOGY

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination

(2011) Duane R. Wesemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE