Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs

(2017) Chien-Chang Chen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous immunotherapy induces gastrointestinal LAP + regulatory T cells and prevents food-induced anaphylaxis

(2017) Leticia Tordesillas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-bet inhibits innate lymphoid cell–mediated eosinophilic airway inflammation by suppressing IL-9 production

(2017) Ayako Matsuki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults

(2017) Stacie M. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production

(2017) Laura Maggi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients

(2017) Paulina Wawrzyniak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treatment with grass allergen peptides improves symptoms of grass pollen–induced allergic rhinoconjunctivitis

(2017) Anne K. Ellis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma transition from childhood into adulthood

(2017) Oliver Fuchs et al.   Lancet Respiratory Medicine

The relationship of serum vitamins A, D, E and LL-37 levels with allergic status, tonsillar virus detection and immune response

(2017) Varpu Elenius et al.   PLoS One

Human rhinoviruses enter and induce proliferation of B lymphocytes

(2016) A. Aab et al.   ALLERGY

High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers

(2016) T. Boonpiyathad et al.   ALLERGY

Novel Biologicals for the Treatment of Allergic Diseases and Asthma

(2016) Hern-Tze Tina Tan et al.   CURRENT ALLERGY AND ASTHMA REPORTS

New Biological Insights in the Immunomodulatory Effects of Mucosal Polybacterial Vaccines in Clinical Practice

(2016) Marta Tejera-Alhambra et al.   CURRENT PHARMACEUTICAL DESIGN

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation

(2016) Etsushi Kuroda et al.   IMMUNITY

Allergen Immunotherapy Outcomes and Unmet Needs

(2016) Davide Caimmi et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Novel Delivery Routes for Allergy Immunotherapy

(2016) Gabriela Senti et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease

(2016) Sylwia Smolinska et al.   INFLAMMATORY BOWEL DISEASES

Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1

(2016) Sofía Sirvent et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract

(2016) Johannes Martin Schmid et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Monitoring the epitope recognition profiles of IgE, IgG 1 , and IgG 4 during birch pollen immunotherapy

(2016) Barbara Gepp et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human innate lymphoid cells

(2016) Jenny Mjösberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular and cellular mechanisms of food allergy and food tolerance

(2016) R. Sharon Chinthrajah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbes and asthma: Opportunities for intervention

(2016) Hermelijn H. Smits et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33

(2016) Amit K. Mehta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distinguishing benign from pathologic TH2 immunity in atopic children

(2016) Patrick G. Holt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Advances and highlights in mechanisms of allergic disease in 2015

(2016) Paulina Wawrzyniak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

(2016) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histamine-secreting microbes are increased in the gut of adult asthma patients

(2016) Weronika Barcik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The contributions of allergic sensitization and respiratory pathogens to asthma inception

(2016) Daniel J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells in induced sputum from children with severe asthma

(2016) Prasad Nagakumar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T cells in allergic diseases

(2016) Magali Noval Rivas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

(2016) Thomas Werfel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toward precision medicine and health: Opportunities and challenges in allergic diseases

(2016) Stephen Joseph Galli   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future

(2016) Rudolf Valenta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of regulatory B cells in immune tolerance to allergens and beyond

(2016) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate lymphoid cells in allergic and nonallergic inflammation

(2016) Hideaki Morita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of 2 months of allergen-specific immunotherapy with Bet v 1–derived contiguous overlapping peptides in patients with allergic rhinoconjunctivitis: Results of a phase IIb study

(2016) François Spertini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sublingual or subcutaneous immunotherapy for allergic rhinitis?

(2016) Stephen R. Durham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

(2016) Marek Jutel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dermatophagoides pteronyssinus group 2 allergen bound to 8-OH modified adenine reduces the Th2-mediated airway inflammation without inducing a Th17 response and autoimmunity

(2016) Sara Pratesi et al.   MOLECULAR IMMUNOLOGY

Thy1+IL-7+lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

(2016) Kenta Shinoda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-γ+Th1 Cells or Foxp3+Regulatory T Cells in the Lung

(2016) Do-Hyun Kim et al.   Allergy Asthma & Immunology Research

Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

(2016) Ioana Agache et al.   ALLERGOLOGY INTERNATIONAL

Regulatory T Cells: Differentiation and Function

(2016) G. Plitas et al.   Cancer Immunology Research

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

(2016) J. Bousquet et al.   Clinical and Translational Allergy

A regulatory CD9+B-cell subset inhibits HDM-induced allergic airway inflammation

(2015) F. Braza et al.   ALLERGY

Structural studies of novel glycoconjugates from polymerized allergens (allergoids) and mannans as allergy vaccines

(2015) Ana I. Manzano et al.   GLYCOCONJUGATE JOURNAL

An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers

(2015) Hideaki Morita et al.   IMMUNITY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors

(2015) Salvador Iborra et al.   IMMUNOBIOLOGY

Induction of a Th1 immune response and suppression of IgE via immunotherapy with a recombinant hybrid molecule encapsulated in liposome–protamine–DNA nanoparticles in a model of experimental allergy

(2015) Hamid Reza Nouri et al.   IMMUNOLOGIC RESEARCH

Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis

(2015) Taylor A. Doherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-cell regulation during viral and nonviral asthma exacerbations

(2015) Agnieszka S. Wegrzyn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens

(2015) Alexandra F. Santos et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations

(2015) Stephen J. Teach et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Skin test evaluation of a novel peptide carrier–based vaccine, BM32, in grass pollen–allergic patients

(2015) Verena Niederberger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-10–overexpressing B cells regulate innate and adaptive immune responses

(2015) Barbara Stanic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

(2015) Timothy S.C. Hinks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The 3 major types of innate and adaptive cell-mediated effector immunity

(2015) Francesco Annunziato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell population

(2015) Tali Czarnowicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

International consensus on allergy immunotherapy

(2015) Marek Jutel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

Advances in allergen immunotherapy: Aiming for complete tolerance to allergens

(2015) Cezmi A. Akdis et al.   Science Translational Medicine

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

(2015) Marie Ballester et al.   Scientific Reports

The Known Unknowns of the Human Dendritic Cell Network

(2015) Mélanie Durand et al.   Frontiers in Immunology

Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region

(2015) Philippe Bégin et al.   Clinical and Translational Allergy

The contribution of biotechnology toward progress in diagnosis, management, and treatment of allergic diseases

(2014) O. Palomares et al.   ALLERGY

Distinct regulation of tonsillar immune response in virus infection

(2014) T. Jartti et al.   ALLERGY

Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine

(2014) A. Zaleska et al.   ALLERGY

Orchestrating immune check-point blockade for cancer immunotherapy in combinations

(2014) Jose Luis Perez-Gracia et al.   CURRENT OPINION IN IMMUNOLOGY

Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β

(2014) O Palomares et al.   GENES AND IMMUNITY

Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation

(2014) Masanori Matsumoto et al.   IMMUNITY

Intralymphatic immunotherapy: Time interval between injections is essential

(2014) Thomas M. Kündig et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes

(2014) Ruth Ferstl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunotherapy: What lies beyond

(2014) Thomas B. Casale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens

(2014) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The expression of cannabinoid receptor 1 is significantly increased in atopic patients

(2014) Mar Martín-Fontecha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

(2014) Susanne Sattler et al.   JOURNAL OF AUTOIMMUNITY

1 ,25-Dihydroxyvitamin D3 Potentiates the Beneficial Effects of Allergen Immunotherapy in a Mouse Model of Allergic Asthma: Role for IL-10 and TGF- 

(2014) Y. A. Taher et al.   JOURNAL OF IMMUNOLOGY

Regulatory Role of B Cells in a Murine Model of Allergic Airway Disease

(2014) A. Singh et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: CD4 T Cell-Mast Cell Interactions Alter IgE Receptor Expression and Signaling

(2014) M. Kashyap et al.   JOURNAL OF IMMUNOLOGY

Autoantigen-Specific IL-10-Transduced T Cells Suppress Chronic Arthritis by Promoting the Endogenous Regulatory IL-10 Response

(2014) T. Guichelaar et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice

(2014) John D Campbell et al.   THORAX

Dendritic Cell-Targeted Vaccines

(2014) Lillian Cohn et al.   Frontiers in Immunology

Myeloid dendritic cells type 2 in allergic asthma

(2013) B. Dua et al.   ALLERGY

Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite

(2013) S. Baris et al.   ALLERGY

Tolerogenic CX3CR1+B cells suppress food allergy-induced intestinal inflammation in mice

(2013) Z.-Q. Liu et al.   ALLERGY

Sensing of cell death by myeloid C-type lectin receptors

(2013) David Sancho et al.   CURRENT OPINION IN IMMUNOLOGY

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma

(2013) Kai-Michael Beeh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of a short course of specific immunotherapy in patients with allergic rhinoconjunctivitis to ragweed pollen

(2013) Piyush Patel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

(2013) Roland Klingenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

TSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation

(2013) Huan-Ping Zhang et al.   Scientific Reports

Update on Immune Mechanisms Associated with Sublingual Immunotherapy: Practical Implications for the Clinician

(2013) Philippe Moingeon   Journal of Allergy and Clinical Immunology-In Practice

Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling

(2012) Y. C. Yang et al.   ALLERGY

Anti-CD45RB/Anti-TIM-1-Induced Tolerance Requires Regulatory B Cells

(2012) K. M. Lee et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chemical Probes for the Recognition of Cannabinoid Receptors in Native Systems

(2012) Lidia Martín-Couce et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection

(2012) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

(2012) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

(2012) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2

(2012) Natalija Novak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

(2012) Umut Can Kücüksezer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Can we produce true tolerance in patients with food allergy?

(2012) M. Cecilia Berin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evidence for a stepwise program of extrathymic T cell development within the human tonsil

(2012) Susan McClory et al.   JOURNAL OF CLINICAL INVESTIGATION

Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

(2012) Grazia Andolfi et al.   MOLECULAR THERAPY

Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic airway disease are CD5+, express TGF-β and co-localize with CD4+Foxp3+ T cells

(2012) P Natarajan et al.   Mucosal Immunology

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

Transcription factor Foxp3 and its protein partners form a complex regulatory network

(2012) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Therapies for allergic inflammation: refining strategies to induce tolerance

(2012) Cezmi A Akdis   NATURE MEDICINE

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Optimal Isolation of Functional Foxp3+ Induced Regulatory T Cells Using DEREG Mice

(2012) Abdul Mannan Baru et al.   PLoS One

Adjuvants for allergy vaccines

(2012) Philippe Moingeon   Human Vaccines & Immunotherapeutics

VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

(2011) Friedrich Horak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Molecular mechanisms underlying the regulation and functional plasticity of FOXP3+ regulatory T cells

(2011) Y Gao et al.   GENES AND IMMUNITY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

Covalent Coupling of Vitamin D3 to the Major Cat Allergen Fel d 1 Improves the Effects of Allergen-Specific Immunotherapy in a Mouse Model for Cat Allergy

(2011) Jeanette Grundström et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy

(2011) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The many routes of dendritic cells to ensure immune regulation

(2011) Oscar Palomares et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bet v 1–specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1–specific T-cell effector function in an activation-dependent manner

(2011) Klaus G. Schmetterer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective epithelial barrier function in asthma

(2011) Chang Xiao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of the immune response and inflammation by histamine and histamine receptors

(2011) Liam O’Mahony et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of allergen-specific immunotherapy

(2011) Cezmi A. Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance

(2011) Oscar Palomares et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

(2011) Qing Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice

(2011) L Mascarell et al.   Mucosal Immunology

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

(2011) William W. Busse et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Transforming Growth Factor-β Receptor Type II Expression by CD4+ T Cells in Peyer's Patches Is Essential for Oral Tolerance Induction

(2011) Rebekah S. Gilbert et al.   PLoS One

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in children

(2010) M. Rosewich et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of Treg in immune regulation of allergic diseases

(2010) Oscar Palomares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells

(2010) W Hansen et al.   GENES AND IMMUNITY

Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection

(2010) Patricia Neves et al.   IMMUNITY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites

(2010) Valentina Pacciani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells

(2010) Alicia N. McMurchy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways

(2010) S Navarro et al.   Mucosal Immunology

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Efficiency of inactivated vaccines against heartwater in Burkina Faso: Impact of Ehrlichia ruminantium genetic diversity

(2010) Hassane Adakal et al.   VACCINE

Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction

(2009) N. Saint-Lu et al.   ALLERGY

The effect of oral steroids with and without vitamin D3on early efficacy of immunotherapy in asthmatic children

(2009) P. Majak et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial

(2009) G. Senti et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells

(2009) Silvia Gregori et al.   HUMAN IMMUNOLOGY

Natural Self-Assembly of Allergen-S-Layer Fusion Proteins Is No Prerequisite for Reduced Allergenicity and T Cell Stimulatory Capacity

(2009) Marianne Gerstmayr et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Dual nature of T cell–epithelium interaction in chronic rhinosinusitis

(2009) Tomasz M. Basinski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy

(2009) Nicole Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+inducible regulatory T cells

(2009) Sven Klunker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unique Phenotype of Human Tonsillar and In Vitro-Induced FOXP3+CD8+ T Cells

(2009) K. Siegmund et al.   JOURNAL OF IMMUNOLOGY

Therapeutic manipulation of immune tolerance in allergic disease

(2009) Mübeccel Akdis et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll-like receptors

(2008) F. Meiler et al.   ALLERGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Heterogeneous response of nasal and lung fibroblasts to transforming growth factor-β1

(2008) M. Nonaka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction

(2008) Giorgia Gri et al.   IMMUNITY

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

CD4+T-regulatory cells: toward therapy for human diseases

(2008) Sarah E. Allan et al.   IMMUNOLOGICAL REVIEWS

In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure

(2008) Flurina Meiler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE